ARG2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006941Biological processstriated muscle contraction
GO_0001657Biological processureteric bud development
GO_0071650Biological processnegative regulation of chemokine (C-C motif) ligand 5 production
GO_2000774Biological processpositive regulation of cellular senescence
GO_0045087Biological processinnate immune response
GO_0002829Biological processnegative regulation of type 2 immune response
GO_1903426Biological processregulation of reactive oxygen species biosynthetic process
GO_0002250Biological processadaptive immune response
GO_0071644Biological processnegative regulation of chemokine (C-C motif) ligand 4 production
GO_0019547Biological processarginine catabolic process to ornithine
GO_0000050Biological processurea cycle
GO_0032696Biological processnegative regulation of interleukin-13 production
GO_0032651Biological processregulation of interleukin-1 beta production
GO_0006809Biological processnitric oxide biosynthetic process
GO_1905403Biological processnegative regulation of activated CD8-positive, alpha-beta T cell apoptotic process
GO_1900425Biological processnegative regulation of defense response to bacterium
GO_0032700Biological processnegative regulation of interleukin-17 production
GO_0032720Biological processnegative regulation of tumor necrosis factor production
GO_0071641Biological processnegative regulation of macrophage inflammatory protein 1 alpha production
GO_2000562Biological processnegative regulation of CD4-positive, alpha-beta T cell proliferation
GO_0005739Cellular componentmitochondrion
GO_0005759Cellular componentmitochondrial matrix
GO_0005737Cellular componentcytoplasm
GO_0030145Molecular functionmanganese ion binding
GO_0004053Molecular functionarginase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameARG2
Protein nameArginase-2, mitochondrial (EC 3.5.3.1) (Arginase II) (Kidney-type arginase) (Non-hepatic arginase) (Type II arginase)
Synonyms
DescriptionFUNCTION: May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells . May suppress inflammation-related signaling in asthmatic airway epithelium . May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism (By similarity). In fetal dendritic cells may play a role in promoting immune suppression and T cell TNF-alpha production during gestation . Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction . Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling . Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity . Since NOS is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase-2 plays a role in both male and female sexual arousal . .

AccessionsP78540
ENST00000261783.4