APPBP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0006886Biological processintracellular protein transport
GO_0046907Biological processintracellular transport
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0005654Cellular componentnucleoplasm
GO_0031462Cellular componentCul2-RING ubiquitin ligase complex
GO_0005875Cellular componentmicrotubule associated complex
GO_0005874Cellular componentmicrotubule
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0003777Molecular functionmicrotubule motor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAPPBP2
Protein nameAmyloid protein-binding protein 2 (Amyloid beta precursor protein-binding protein 2) (APP-BP2) (Protein interacting with APP tail 1)
Amyloid beta precursor protein binding protein 2
SynonymsKIAA0228
PAT1
DescriptionFUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation . The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms . The CRL2(APPBP2) complex specifically recognizes proteins with a -Arg-Xaa-Xaa-Gly degron at the C-terminus, leading to their ubiquitination and degradation . The CRL2(APPBP2) complex mediates ubiquitination and degradation of truncated SELENOV selenoproteins produced by failed UGA/Sec decoding, which end with a -Arg-Xaa-Xaa-Gly degron . May play a role in intracellular protein transport: may be involved in the translocation of APP along microtubules toward the cell surface . .

AccessionsQ92624
K7ENN3
K7EIZ9
ENST00000083182.8
ENST00000588668.5
ENST00000589341.5
K7EN61
ENST00000585368.1