Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 19 studies | 29% ± 9% | |
oligodendrocyte | 14 studies | 36% ± 14% | |
fibroblast | 14 studies | 22% ± 6% | |
astrocyte | 11 studies | 31% ± 13% | |
adipocyte | 10 studies | 35% ± 10% | |
oligodendrocyte precursor cell | 9 studies | 31% ± 14% | |
glutamatergic neuron | 8 studies | 40% ± 25% | |
GABAergic neuron | 8 studies | 39% ± 22% | |
macrophage | 7 studies | 28% ± 7% | |
microglial cell | 7 studies | 26% ± 8% | |
epithelial cell | 6 studies | 33% ± 10% | |
type II pneumocyte | 6 studies | 19% ± 6% | |
neuron | 5 studies | 32% ± 15% | |
endothelial cell of lymphatic vessel | 5 studies | 25% ± 6% | |
pericyte | 5 studies | 22% ± 4% | |
interneuron | 5 studies | 41% ± 22% | |
granule cell | 4 studies | 20% ± 5% | |
lymphocyte | 4 studies | 19% ± 4% | |
connective tissue cell | 4 studies | 22% ± 1% | |
myofibroblast cell | 4 studies | 20% ± 7% | |
smooth muscle cell | 4 studies | 20% ± 4% | |
goblet cell | 4 studies | 29% ± 18% | |
GABAergic interneuron | 3 studies | 21% ± 2% | |
retinal bipolar neuron | 3 studies | 18% ± 2% | |
retinal cone cell | 3 studies | 20% ± 2% | |
retinal pigment epithelial cell | 3 studies | 28% ± 15% | |
ciliated cell | 3 studies | 24% ± 2% | |
myeloid cell | 3 studies | 19% ± 3% | |
Mueller cell | 3 studies | 18% ± 1% | |
rod bipolar cell | 3 studies | 21% ± 2% | |
dendritic cell | 3 studies | 17% ± 1% | |
ependymal cell | 3 studies | 29% ± 12% | |
endothelial cell of artery | 3 studies | 19% ± 2% | |
T cell | 3 studies | 18% ± 2% | |
alveolar macrophage | 3 studies | 22% ± 8% | |
monocyte | 3 studies | 21% ± 1% | |
type I pneumocyte | 3 studies | 22% ± 5% | |
mast cell | 3 studies | 24% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2407.76 | 1445 / 1445 | 100% | 16.10 | 183 / 183 |
breast | 100% | 3080.64 | 459 / 459 | 100% | 27.91 | 1116 / 1118 |
prostate | 100% | 2805.62 | 245 / 245 | 100% | 22.49 | 501 / 502 |
brain | 100% | 2984.70 | 2640 / 2642 | 100% | 27.47 | 704 / 705 |
ovary | 100% | 3892.00 | 180 / 180 | 100% | 14.00 | 429 / 430 |
lung | 100% | 2373.16 | 576 / 578 | 100% | 15.51 | 1153 / 1155 |
bladder | 100% | 3004.90 | 21 / 21 | 99% | 13.63 | 500 / 504 |
thymus | 100% | 2632.92 | 653 / 653 | 99% | 15.69 | 600 / 605 |
uterus | 100% | 3449.01 | 170 / 170 | 99% | 14.21 | 453 / 459 |
stomach | 100% | 1774.54 | 359 / 359 | 99% | 11.88 | 282 / 286 |
pancreas | 100% | 1442.98 | 327 / 328 | 98% | 12.75 | 175 / 178 |
intestine | 100% | 2641.24 | 966 / 966 | 98% | 10.90 | 515 / 527 |
kidney | 100% | 1920.31 | 89 / 89 | 98% | 16.55 | 879 / 901 |
adrenal gland | 100% | 2805.42 | 258 / 258 | 97% | 13.46 | 224 / 230 |
skin | 100% | 2610.83 | 1808 / 1809 | 95% | 16.43 | 450 / 472 |
liver | 100% | 968.30 | 225 / 226 | 90% | 7.14 | 365 / 406 |
adipose | 100% | 3277.15 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2385.74 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 9.18 | 29 / 29 |
spleen | 100% | 2291.53 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 12.17 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 3.64 | 1 / 1 |
muscle | 100% | 1662.04 | 800 / 803 | 0% | 0 | 0 / 0 |
heart | 96% | 1218.88 | 828 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 89% | 9.40 | 71 / 80 |
peripheral blood | 69% | 1014.58 | 642 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0016567 | Biological process | protein ubiquitination |
GO_0006886 | Biological process | intracellular protein transport |
GO_0046907 | Biological process | intracellular transport |
GO_0043161 | Biological process | proteasome-mediated ubiquitin-dependent protein catabolic process |
GO_0005654 | Cellular component | nucleoplasm |
GO_0031462 | Cellular component | Cul2-RING ubiquitin ligase complex |
GO_0005875 | Cellular component | microtubule associated complex |
GO_0005874 | Cellular component | microtubule |
GO_0030659 | Cellular component | cytoplasmic vesicle membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_1990756 | Molecular function | ubiquitin-like ligase-substrate adaptor activity |
GO_0003777 | Molecular function | microtubule motor activity |
GO_0005515 | Molecular function | protein binding |
Gene name | APPBP2 |
Protein name | Amyloid protein-binding protein 2 (Amyloid beta precursor protein-binding protein 2) (APP-BP2) (Protein interacting with APP tail 1) Amyloid beta precursor protein binding protein 2 |
Synonyms | KIAA0228 PAT1 |
Description | FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation . The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms . The CRL2(APPBP2) complex specifically recognizes proteins with a -Arg-Xaa-Xaa-Gly degron at the C-terminus, leading to their ubiquitination and degradation . The CRL2(APPBP2) complex mediates ubiquitination and degradation of truncated SELENOV selenoproteins produced by failed UGA/Sec decoding, which end with a -Arg-Xaa-Xaa-Gly degron . May play a role in intracellular protein transport: may be involved in the translocation of APP along microtubules toward the cell surface . . |
Accessions | Q92624 K7ENN3 K7EIZ9 ENST00000083182.8 ENST00000588668.5 ENST00000589341.5 K7EN61 ENST00000585368.1 |