ANO6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032060Biological processbleb assembly
GO_0061589Biological processcalcium activated phosphatidylserine scrambling
GO_0006821Biological processchloride transport
GO_0061590Biological processcalcium activated phosphatidylcholine scrambling
GO_0034220Biological processmonoatomic ion transmembrane transport
GO_0090026Biological processpositive regulation of monocyte chemotaxis
GO_0035590Biological processpurinergic nucleotide receptor signaling pathway
GO_0034767Biological processpositive regulation of monoatomic ion transmembrane transport
GO_0007596Biological processblood coagulation
GO_0046931Biological processpore complex assembly
GO_1903766Biological processpositive regulation of potassium ion export across plasma membrane
GO_1902476Biological processchloride transmembrane transport
GO_0017121Biological processplasma membrane phospholipid scrambling
GO_0002543Biological processactivation of blood coagulation via clotting cascade
GO_0097045Biological processphosphatidylserine exposure on blood platelet
GO_0060100Biological processpositive regulation of phagocytosis, engulfment
GO_0043065Biological processpositive regulation of apoptotic process
GO_0030501Biological processpositive regulation of bone mineralization
GO_2000353Biological processpositive regulation of endothelial cell apoptotic process
GO_0045794Biological processnegative regulation of cell volume
GO_0035725Biological processsodium ion transmembrane transport
GO_0070588Biological processcalcium ion transmembrane transport
GO_0035579Cellular componentspecific granule membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0009986Cellular componentcell surface
GO_0005829Cellular componentcytosol
GO_0034707Cellular componentchloride channel complex
GO_0070821Cellular componenttertiary granule membrane
GO_0017128Molecular functionphospholipid scramblase activity
GO_0005244Molecular functionvoltage-gated monoatomic ion channel activity
GO_0005247Molecular functionvoltage-gated chloride channel activity
GO_0005229Molecular functionintracellularly calcium-gated chloride channel activity
GO_0046872Molecular functionmetal ion binding
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding
GO_0005254Molecular functionchloride channel activity
GO_0005227Molecular functioncalcium-activated cation channel activity

IV. Literature review

[source]
Gene nameANO6
Protein nameAnoctamin
Anoctamin 6
Anoctamin-6 (Small-conductance calcium-activated nonselective cation channel) (SCAN channel) (Transmembrane protein 16F)
SynonymsTMEM16F
DescriptionFUNCTION: Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes. .; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, is activated by spike protein which increases the amplitude of spontaneous Ca(2+) signals and is required for spike-mediated syncytia. .

AccessionsENST00000679426.1
ENST00000681156.1
A0A7P0TAW4
A0A7P0TBC5
ENST00000425752.6 [Q4KMQ2-4]
A0A7P0TAF4
ENST00000680498.1
A0A7P0TBI1
ENST00000679761.1
ENST00000680371.1
ENST00000680201.1 [Q4KMQ2-1]
A0A7P0T8Y2
ENST00000441606.2 [Q4KMQ2-3]
ENST00000423947.7 [Q4KMQ2-2]
Q4KMQ2
ENST00000681817.1
ENST00000550630.5
A0A7P0TBD5
F8VX71
ENST00000320560.13 [Q4KMQ2-1]