Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 26 studies | 31% ± 13% | |
fibroblast | 21 studies | 30% ± 11% | |
pericyte | 18 studies | 36% ± 17% | |
smooth muscle cell | 13 studies | 31% ± 10% | |
astrocyte | 13 studies | 34% ± 17% | |
macrophage | 12 studies | 31% ± 13% | |
type I pneumocyte | 10 studies | 30% ± 14% | |
platelet | 10 studies | 32% ± 11% | |
oligodendrocyte precursor cell | 10 studies | 35% ± 17% | |
microglial cell | 10 studies | 32% ± 13% | |
adipocyte | 9 studies | 68% ± 16% | |
epithelial cell | 8 studies | 31% ± 9% | |
classical monocyte | 7 studies | 22% ± 4% | |
dendritic cell | 7 studies | 24% ± 6% | |
myofibroblast cell | 6 studies | 26% ± 11% | |
GABAergic neuron | 5 studies | 41% ± 15% | |
myeloid cell | 5 studies | 21% ± 5% | |
cardiac muscle cell | 5 studies | 32% ± 9% | |
endothelial cell of artery | 5 studies | 20% ± 2% | |
endothelial cell of vascular tree | 5 studies | 30% ± 14% | |
endothelial cell of lymphatic vessel | 5 studies | 30% ± 11% | |
T cell | 4 studies | 19% ± 3% | |
capillary endothelial cell | 4 studies | 16% ± 0% | |
glomerular endothelial cell | 4 studies | 45% ± 6% | |
megakaryocyte | 4 studies | 36% ± 13% | |
basal cell | 4 studies | 25% ± 17% | |
hepatocyte | 4 studies | 42% ± 18% | |
muscle cell | 4 studies | 41% ± 19% | |
glutamatergic neuron | 4 studies | 48% ± 16% | |
connective tissue cell | 4 studies | 29% ± 10% | |
monocyte | 4 studies | 26% ± 8% | |
mesothelial cell | 3 studies | 29% ± 9% | |
non-classical monocyte | 3 studies | 21% ± 3% | |
vein endothelial cell | 3 studies | 32% ± 14% | |
abnormal cell | 3 studies | 42% ± 17% | |
retinal pigment epithelial cell | 3 studies | 34% ± 9% | |
ependymal cell | 3 studies | 36% ± 17% | |
adventitial cell | 3 studies | 28% ± 8% | |
neuron | 3 studies | 25% ± 6% | |
mast cell | 3 studies | 22% ± 5% | |
interneuron | 3 studies | 40% ± 19% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 8522.49 | 459 / 459 | 99% | 47.46 | 1107 / 1118 |
lung | 100% | 9168.56 | 577 / 578 | 99% | 36.01 | 1142 / 1155 |
kidney | 100% | 3349.57 | 89 / 89 | 99% | 71.18 | 889 / 901 |
esophagus | 98% | 7504.60 | 1418 / 1445 | 99% | 43.68 | 182 / 183 |
bladder | 100% | 9536.38 | 21 / 21 | 97% | 37.50 | 491 / 504 |
liver | 99% | 3259.96 | 224 / 226 | 98% | 40.42 | 397 / 406 |
thymus | 100% | 3911.50 | 651 / 653 | 96% | 38.76 | 583 / 605 |
uterus | 100% | 8420.61 | 170 / 170 | 96% | 30.18 | 440 / 459 |
adrenal gland | 99% | 4681.78 | 255 / 258 | 97% | 48.85 | 223 / 230 |
ovary | 100% | 7892.01 | 180 / 180 | 95% | 22.52 | 408 / 430 |
pancreas | 96% | 2360.90 | 316 / 328 | 97% | 44.02 | 172 / 178 |
skin | 99% | 4682.43 | 1796 / 1809 | 94% | 33.54 | 442 / 472 |
intestine | 92% | 6460.61 | 893 / 966 | 97% | 31.43 | 509 / 527 |
prostate | 96% | 4590.04 | 236 / 245 | 86% | 20.10 | 431 / 502 |
stomach | 81% | 3404.74 | 289 / 359 | 99% | 37.42 | 283 / 286 |
brain | 39% | 718.57 | 1019 / 2642 | 97% | 34.76 | 686 / 705 |
adipose | 100% | 10450.01 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 10354.82 | 1335 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 8681.82 | 803 / 803 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 13.90 | 1 / 1 |
heart | 95% | 3620.63 | 815 / 861 | 0% | 0 | 0 / 0 |
spleen | 90% | 1890.07 | 218 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 89% | 26.20 | 40 / 45 |
eye | 0% | 0 | 0 / 0 | 75% | 16.50 | 60 / 80 |
lymph node | 0% | 0 | 0 / 0 | 62% | 11.38 | 18 / 29 |
peripheral blood | 46% | 1704.46 | 429 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0032060 | Biological process | bleb assembly |
GO_0061589 | Biological process | calcium activated phosphatidylserine scrambling |
GO_0006821 | Biological process | chloride transport |
GO_0061590 | Biological process | calcium activated phosphatidylcholine scrambling |
GO_0034220 | Biological process | monoatomic ion transmembrane transport |
GO_0090026 | Biological process | positive regulation of monocyte chemotaxis |
GO_0035590 | Biological process | purinergic nucleotide receptor signaling pathway |
GO_0034767 | Biological process | positive regulation of monoatomic ion transmembrane transport |
GO_0007596 | Biological process | blood coagulation |
GO_0046931 | Biological process | pore complex assembly |
GO_1903766 | Biological process | positive regulation of potassium ion export across plasma membrane |
GO_1902476 | Biological process | chloride transmembrane transport |
GO_0017121 | Biological process | plasma membrane phospholipid scrambling |
GO_0002543 | Biological process | activation of blood coagulation via clotting cascade |
GO_0097045 | Biological process | phosphatidylserine exposure on blood platelet |
GO_0060100 | Biological process | positive regulation of phagocytosis, engulfment |
GO_0043065 | Biological process | positive regulation of apoptotic process |
GO_0030501 | Biological process | positive regulation of bone mineralization |
GO_2000353 | Biological process | positive regulation of endothelial cell apoptotic process |
GO_0045794 | Biological process | negative regulation of cell volume |
GO_0035725 | Biological process | sodium ion transmembrane transport |
GO_0070588 | Biological process | calcium ion transmembrane transport |
GO_0035579 | Cellular component | specific granule membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0070062 | Cellular component | extracellular exosome |
GO_0009986 | Cellular component | cell surface |
GO_0005829 | Cellular component | cytosol |
GO_0034707 | Cellular component | chloride channel complex |
GO_0070821 | Cellular component | tertiary granule membrane |
GO_0017128 | Molecular function | phospholipid scramblase activity |
GO_0005244 | Molecular function | voltage-gated monoatomic ion channel activity |
GO_0005247 | Molecular function | voltage-gated chloride channel activity |
GO_0005229 | Molecular function | intracellularly calcium-gated chloride channel activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0046983 | Molecular function | protein dimerization activity |
GO_0005515 | Molecular function | protein binding |
GO_0005254 | Molecular function | chloride channel activity |
GO_0005227 | Molecular function | calcium-activated cation channel activity |
Gene name | ANO6 |
Protein name | Anoctamin Anoctamin 6 Anoctamin-6 (Small-conductance calcium-activated nonselective cation channel) (SCAN channel) (Transmembrane protein 16F) |
Synonyms | TMEM16F |
Description | FUNCTION: Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes. .; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, is activated by spike protein which increases the amplitude of spontaneous Ca(2+) signals and is required for spike-mediated syncytia. . |
Accessions | ENST00000679426.1 ENST00000681156.1 A0A7P0TAW4 A0A7P0TBC5 ENST00000425752.6 [Q4KMQ2-4] A0A7P0TAF4 ENST00000680498.1 A0A7P0TBI1 ENST00000679761.1 ENST00000680371.1 ENST00000680201.1 [Q4KMQ2-1] A0A7P0T8Y2 ENST00000441606.2 [Q4KMQ2-3] ENST00000423947.7 [Q4KMQ2-2] Q4KMQ2 ENST00000681817.1 ENST00000550630.5 A0A7P0TBD5 F8VX71 ENST00000320560.13 [Q4KMQ2-1] |