ANKH report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071344Biological processdiphosphate metabolic process
GO_0055074Biological processcalcium ion homeostasis
GO_0055062Biological processphosphate ion homeostasis
GO_0035435Biological processphosphate ion transmembrane transport
GO_0046716Biological processmuscle cell cellular homeostasis
GO_0055085Biological processtransmembrane transport
GO_0030500Biological processregulation of bone mineralization
GO_1904383Biological processresponse to sodium phosphate
GO_0030505Biological processinorganic diphosphate transport
GO_0030282Biological processbone mineralization
GO_0071529Biological processcementum mineralization
GO_0140928Biological processinhibition of non-skeletal tissue mineralization
GO_0001501Biological processskeletal system development
GO_0010467Biological processgene expression
GO_1904669Biological processATP export
GO_0007626Biological processlocomotory behavior
GO_0019867Cellular componentouter membrane
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005315Molecular functionphosphate transmembrane transporter activity
GO_0005347Molecular functionATP transmembrane transporter activity
GO_0030504Molecular functioninorganic diphosphate transmembrane transporter activity

IV. Literature review

[source]
Gene nameANKH
Protein nameMineralization regulator ANKH (ATP carrier protein ANKH) (Progressive ankylosis protein homolog) (ANK)
ANKH inorganic pyrophosphate transport regulator
SynonymsKIAA1581
UNQ241/PRO274
DescriptionFUNCTION: Transports adenosine triphosphate (ATP) and possibly other nucleoside triphosphates (NTPs) from cytosol to the extracellular space. Mainly regulates their levels locally in peripheral tissues while playing a minor systemic role. Prevents abnormal ectopic mineralization of the joints by regulating the extracellular levels of the calcification inhibitor inorganic pyrophosphate (PPi), which originates from the conversion of extracellular NTPs to NMPs and PPis by ENPP1 . Regulates the release of the TCA cycle intermediates to the extracellular space, in particular citrate, succinate and malate. Extracellular citrate mostly present in bone tissue is required for osteogenic differentiation of mesenchymal stem cells, stabilization of hydroxyapatite structure and overall bone strength . The transport mechanism remains to be elucidated (Probable). .

AccessionsQ9HCJ1
D6RGI5
ENST00000284268.8 [Q9HCJ1-1]
A0A2R8Y5E7
ENST00000646501.1
ENST00000505140.1