Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 17 studies | 35% ± 18% | |
macrophage | 16 studies | 31% ± 13% | |
oligodendrocyte | 15 studies | 42% ± 16% | |
glutamatergic neuron | 12 studies | 50% ± 23% | |
GABAergic neuron | 11 studies | 51% ± 24% | |
astrocyte | 11 studies | 30% ± 14% | |
oligodendrocyte precursor cell | 11 studies | 36% ± 17% | |
microglial cell | 11 studies | 27% ± 9% | |
neuron | 7 studies | 36% ± 16% | |
retinal cone cell | 7 studies | 47% ± 13% | |
myeloid cell | 7 studies | 29% ± 9% | |
interneuron | 6 studies | 51% ± 29% | |
retinal ganglion cell | 6 studies | 32% ± 11% | |
fibroblast | 6 studies | 34% ± 17% | |
epithelial cell | 6 studies | 32% ± 10% | |
endothelial cell of lymphatic vessel | 6 studies | 35% ± 15% | |
cardiac muscle cell | 5 studies | 41% ± 10% | |
dendritic cell | 5 studies | 22% ± 3% | |
CD4-positive, alpha-beta T cell | 4 studies | 17% ± 3% | |
pericyte | 4 studies | 22% ± 4% | |
granule cell | 4 studies | 40% ± 13% | |
basal cell | 4 studies | 34% ± 17% | |
retinal pigment epithelial cell | 4 studies | 32% ± 9% | |
retinal rod cell | 4 studies | 26% ± 3% | |
smooth muscle cell | 4 studies | 25% ± 11% | |
monocyte | 4 studies | 19% ± 2% | |
pancreatic A cell | 3 studies | 41% ± 20% | |
type B pancreatic cell | 3 studies | 44% ± 24% | |
conventional dendritic cell | 3 studies | 20% ± 3% | |
naive thymus-derived CD4-positive, alpha-beta T cell | 3 studies | 19% ± 4% | |
GABAergic interneuron | 3 studies | 46% ± 8% | |
retinal bipolar neuron | 3 studies | 26% ± 8% | |
tissue-resident macrophage | 3 studies | 33% ± 13% | |
rod bipolar cell | 3 studies | 42% ± 10% | |
mast cell | 3 studies | 42% ± 28% | |
hepatocyte | 3 studies | 49% ± 26% | |
lymphocyte | 3 studies | 32% ± 5% | |
transit amplifying cell | 3 studies | 38% ± 24% | |
goblet cell | 3 studies | 20% ± 1% | |
regulatory T cell | 3 studies | 18% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 11187.41 | 245 / 245 | 100% | 87.27 | 502 / 502 |
brain | 100% | 8282.47 | 2639 / 2642 | 99% | 27.54 | 699 / 705 |
thymus | 100% | 5274.63 | 652 / 653 | 98% | 34.00 | 594 / 605 |
intestine | 100% | 3450.58 | 966 / 966 | 97% | 31.73 | 512 / 527 |
liver | 100% | 3260.93 | 226 / 226 | 97% | 19.47 | 392 / 406 |
breast | 100% | 4097.42 | 459 / 459 | 95% | 27.42 | 1062 / 1118 |
esophagus | 98% | 3077.24 | 1414 / 1445 | 97% | 22.46 | 177 / 183 |
stomach | 96% | 1984.11 | 344 / 359 | 96% | 30.39 | 275 / 286 |
lung | 99% | 3166.32 | 570 / 578 | 93% | 23.56 | 1078 / 1155 |
pancreas | 96% | 2230.31 | 314 / 328 | 96% | 30.42 | 170 / 178 |
ovary | 100% | 4941.83 | 180 / 180 | 91% | 17.99 | 391 / 430 |
kidney | 97% | 2334.70 | 86 / 89 | 81% | 13.48 | 733 / 901 |
uterus | 100% | 3047.42 | 170 / 170 | 78% | 16.10 | 356 / 459 |
skin | 100% | 6117.21 | 1808 / 1809 | 75% | 29.16 | 354 / 472 |
bladder | 100% | 2614.86 | 21 / 21 | 71% | 17.76 | 358 / 504 |
adrenal gland | 82% | 1729.43 | 211 / 258 | 73% | 31.47 | 169 / 230 |
blood vessel | 100% | 11513.01 | 1335 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 5545.14 | 803 / 803 | 0% | 0 | 0 / 0 |
adipose | 100% | 3877.03 | 1203 / 1204 | 0% | 0 | 0 / 0 |
spleen | 100% | 2731.79 | 240 / 241 | 0% | 0 | 0 / 0 |
heart | 99% | 6698.82 | 851 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 88% | 10.46 | 70 / 80 |
tonsil | 0% | 0 | 0 / 0 | 82% | 27.60 | 37 / 45 |
lymph node | 0% | 0 | 0 / 0 | 76% | 10.48 | 22 / 29 |
peripheral blood | 75% | 1640.45 | 695 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0071344 | Biological process | diphosphate metabolic process |
GO_0055074 | Biological process | calcium ion homeostasis |
GO_0055062 | Biological process | phosphate ion homeostasis |
GO_0035435 | Biological process | phosphate ion transmembrane transport |
GO_0046716 | Biological process | muscle cell cellular homeostasis |
GO_0055085 | Biological process | transmembrane transport |
GO_0030500 | Biological process | regulation of bone mineralization |
GO_1904383 | Biological process | response to sodium phosphate |
GO_0030505 | Biological process | inorganic diphosphate transport |
GO_0030282 | Biological process | bone mineralization |
GO_0071529 | Biological process | cementum mineralization |
GO_0140928 | Biological process | inhibition of non-skeletal tissue mineralization |
GO_0001501 | Biological process | skeletal system development |
GO_0010467 | Biological process | gene expression |
GO_1904669 | Biological process | ATP export |
GO_0007626 | Biological process | locomotory behavior |
GO_0019867 | Cellular component | outer membrane |
GO_0005576 | Cellular component | extracellular region |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0005315 | Molecular function | phosphate transmembrane transporter activity |
GO_0005347 | Molecular function | ATP transmembrane transporter activity |
GO_0030504 | Molecular function | inorganic diphosphate transmembrane transporter activity |
Gene name | ANKH |
Protein name | Mineralization regulator ANKH (ATP carrier protein ANKH) (Progressive ankylosis protein homolog) (ANK) ANKH inorganic pyrophosphate transport regulator |
Synonyms | KIAA1581 UNQ241/PRO274 |
Description | FUNCTION: Transports adenosine triphosphate (ATP) and possibly other nucleoside triphosphates (NTPs) from cytosol to the extracellular space. Mainly regulates their levels locally in peripheral tissues while playing a minor systemic role. Prevents abnormal ectopic mineralization of the joints by regulating the extracellular levels of the calcification inhibitor inorganic pyrophosphate (PPi), which originates from the conversion of extracellular NTPs to NMPs and PPis by ENPP1 . Regulates the release of the TCA cycle intermediates to the extracellular space, in particular citrate, succinate and malate. Extracellular citrate mostly present in bone tissue is required for osteogenic differentiation of mesenchymal stem cells, stabilization of hydroxyapatite structure and overall bone strength . The transport mechanism remains to be elucidated (Probable). . |
Accessions | Q9HCJ1 D6RGI5 ENST00000284268.8 [Q9HCJ1-1] A0A2R8Y5E7 ENST00000646501.1 ENST00000505140.1 |