ALYREF report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006405Biological processRNA export from nucleus
GO_0006397Biological processmRNA processing
GO_0001649Biological processosteoblast differentiation
GO_0006406Biological processmRNA export from nucleus
GO_0008380Biological processRNA splicing
GO_0000346Cellular componenttranscription export complex
GO_0016020Cellular componentmembrane
GO_0016607Cellular componentnuclear speck
GO_0035145Cellular componentexon-exon junction complex
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0071013Cellular componentcatalytic step 2 spliceosome
GO_0000781Cellular componentchromosome, telomeric region
GO_0005634Cellular componentnucleus
GO_0062153Molecular functionC5-methylcytidine-containing RNA reader activity
GO_0003729Molecular functionmRNA binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameALYREF
Protein nameAly/REF export factor
THO complex subunit 4 (Tho4) (Ally of AML-1 and LEF-1) (Aly/REF export factor) (Transcriptional coactivator Aly/REF) (bZIP-enhancing factor BEF)
SynonymsBEF
THOC4
ALY
DescriptionFUNCTION: Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway) . Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA . TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm . TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1 . The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production; ALYREF/THOC4 mediates the recruitment of the TREX complex to the intronless viral mRNA . Required for TREX complex assembly and for linking DDX39B to the cap-binding complex (CBC) . In conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim . Involved in the nuclear export of intronless mRNA; proposed to be recruited to intronless mRNA by ATP-bound DDX39B. Involved in transcription elongation and genome stability . Involved in mRNA export of C5-methylcytosine (m5C)-containing mRNAs: specifically recognizes and binds m5C mRNAs and mediates their nucleo-cytoplasmic shuttling . .; FUNCTION: Acts as a chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation. .

AccessionsQ86V81
ENST00000505490.3
E9PB61