Name | Number of supported studies | Average coverage | |
---|---|---|---|
B cell | 5 studies | 23% ± 5% | |
epithelial cell | 5 studies | 34% ± 18% | |
plasmablast | 4 studies | 42% ± 14% | |
endothelial cell | 4 studies | 20% ± 3% | |
classical monocyte | 3 studies | 36% ± 15% | |
non-classical monocyte | 3 studies | 34% ± 15% | |
CD16-positive, CD56-dim natural killer cell, human | 3 studies | 28% ± 1% | |
hematopoietic precursor cell | 3 studies | 36% ± 9% | |
myeloid cell | 3 studies | 34% ± 6% | |
ciliated cell | 3 studies | 34% ± 10% | |
dendritic cell | 3 studies | 39% ± 27% | |
intestinal crypt stem cell | 3 studies | 19% ± 3% | |
erythroblast | 3 studies | 46% ± 20% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 1708.88 | 1444 / 1445 | 100% | 85.19 | 183 / 183 |
ovary | 100% | 1497.19 | 180 / 180 | 100% | 106.56 | 429 / 430 |
skin | 100% | 2515.83 | 1809 / 1809 | 100% | 132.45 | 470 / 472 |
uterus | 100% | 1577.88 | 170 / 170 | 100% | 223.10 | 457 / 459 |
intestine | 100% | 1592.10 | 966 / 966 | 99% | 172.34 | 523 / 527 |
bladder | 100% | 1437.67 | 21 / 21 | 99% | 188.47 | 499 / 504 |
brain | 99% | 937.36 | 2618 / 2642 | 100% | 123.13 | 704 / 705 |
lung | 100% | 1742.32 | 577 / 578 | 99% | 144.55 | 1144 / 1155 |
thymus | 100% | 1576.31 | 653 / 653 | 99% | 108.79 | 598 / 605 |
breast | 100% | 1712.95 | 459 / 459 | 99% | 130.63 | 1105 / 1118 |
prostate | 100% | 1511.91 | 245 / 245 | 99% | 100.19 | 496 / 502 |
stomach | 100% | 1171.94 | 359 / 359 | 99% | 132.08 | 282 / 286 |
pancreas | 98% | 720.60 | 323 / 328 | 99% | 103.12 | 176 / 178 |
adrenal gland | 100% | 1311.42 | 258 / 258 | 93% | 73.92 | 215 / 230 |
kidney | 100% | 1250.07 | 89 / 89 | 93% | 56.76 | 835 / 901 |
liver | 99% | 768.74 | 223 / 226 | 92% | 75.70 | 373 / 406 |
adipose | 100% | 1666.09 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 302.59 | 29 / 29 |
spleen | 100% | 2063.93 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 192.18 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 108.57 | 1 / 1 |
blood vessel | 100% | 1516.64 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 1312.25 | 799 / 803 | 0% | 0 | 0 / 0 |
heart | 98% | 1092.36 | 848 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 98% | 2159.51 | 912 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 96% | 55.60 | 77 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006405 | Biological process | RNA export from nucleus |
GO_0006397 | Biological process | mRNA processing |
GO_0001649 | Biological process | osteoblast differentiation |
GO_0006406 | Biological process | mRNA export from nucleus |
GO_0008380 | Biological process | RNA splicing |
GO_0000346 | Cellular component | transcription export complex |
GO_0016020 | Cellular component | membrane |
GO_0016607 | Cellular component | nuclear speck |
GO_0035145 | Cellular component | exon-exon junction complex |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0071013 | Cellular component | catalytic step 2 spliceosome |
GO_0000781 | Cellular component | chromosome, telomeric region |
GO_0005634 | Cellular component | nucleus |
GO_0062153 | Molecular function | C5-methylcytidine-containing RNA reader activity |
GO_0003729 | Molecular function | mRNA binding |
GO_0003723 | Molecular function | RNA binding |
GO_0005515 | Molecular function | protein binding |
Gene name | ALYREF |
Protein name | Aly/REF export factor THO complex subunit 4 (Tho4) (Ally of AML-1 and LEF-1) (Aly/REF export factor) (Transcriptional coactivator Aly/REF) (bZIP-enhancing factor BEF) |
Synonyms | BEF THOC4 ALY |
Description | FUNCTION: Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway) . Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA . TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm . TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1 . The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production; ALYREF/THOC4 mediates the recruitment of the TREX complex to the intronless viral mRNA . Required for TREX complex assembly and for linking DDX39B to the cap-binding complex (CBC) . In conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim . Involved in the nuclear export of intronless mRNA; proposed to be recruited to intronless mRNA by ATP-bound DDX39B. Involved in transcription elongation and genome stability . Involved in mRNA export of C5-methylcytosine (m5C)-containing mRNAs: specifically recognizes and binds m5C mRNAs and mediates their nucleo-cytoplasmic shuttling . .; FUNCTION: Acts as a chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation. . |
Accessions | Q86V81 ENST00000505490.3 E9PB61 |