Name | Number of supported studies | Average coverage | |
---|---|---|---|
microglial cell | 11 studies | 36% ± 15% | |
fibroblast | 9 studies | 23% ± 14% | |
macrophage | 7 studies | 34% ± 13% | |
endothelial cell | 6 studies | 26% ± 6% | |
adipocyte | 5 studies | 20% ± 3% | |
monocyte | 5 studies | 25% ± 4% | |
type II pneumocyte | 5 studies | 24% ± 6% | |
epithelial cell | 4 studies | 32% ± 14% | |
ciliated cell | 4 studies | 23% ± 8% | |
myeloid cell | 4 studies | 28% ± 9% | |
dendritic cell | 3 studies | 17% ± 1% | |
alveolar macrophage | 3 studies | 29% ± 7% | |
club cell | 3 studies | 22% ± 3% | |
type I pneumocyte | 3 studies | 20% ± 3% | |
goblet cell | 3 studies | 31% ± 16% | |
astrocyte | 3 studies | 37% ± 12% |
Insufficient scRNA-seq data for expression of ALPK1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
thymus | 100% | 2108.85 | 653 / 653 | 100% | 6.32 | 604 / 605 |
breast | 100% | 2336.13 | 459 / 459 | 100% | 8.23 | 1115 / 1118 |
intestine | 100% | 1747.15 | 965 / 966 | 100% | 5.31 | 526 / 527 |
kidney | 100% | 1692.92 | 89 / 89 | 100% | 6.42 | 898 / 901 |
esophagus | 100% | 1857.70 | 1444 / 1445 | 99% | 6.83 | 182 / 183 |
uterus | 100% | 1987.95 | 170 / 170 | 99% | 6.17 | 456 / 459 |
lung | 100% | 2570.34 | 577 / 578 | 99% | 6.71 | 1147 / 1155 |
bladder | 100% | 2293.52 | 21 / 21 | 99% | 5.68 | 499 / 504 |
ovary | 100% | 2270.62 | 180 / 180 | 98% | 4.47 | 423 / 430 |
stomach | 99% | 1298.89 | 356 / 359 | 99% | 5.13 | 283 / 286 |
prostate | 100% | 2206.00 | 245 / 245 | 97% | 3.48 | 489 / 502 |
skin | 100% | 2162.09 | 1809 / 1809 | 97% | 5.54 | 456 / 472 |
pancreas | 97% | 932.19 | 317 / 328 | 97% | 6.66 | 173 / 178 |
liver | 99% | 1048.15 | 224 / 226 | 74% | 2.05 | 300 / 406 |
adrenal gland | 100% | 1919.28 | 258 / 258 | 50% | 1.65 | 114 / 230 |
brain | 46% | 372.43 | 1207 / 2642 | 78% | 2.46 | 549 / 705 |
adipose | 100% | 2034.62 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 6.25 | 29 / 29 |
spleen | 100% | 3980.42 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 1.14 | 1 / 1 |
blood vessel | 100% | 1809.85 | 1334 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 100% | 6302.34 | 926 / 929 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 7.02 | 44 / 45 |
eye | 0% | 0 | 0 / 0 | 94% | 3.76 | 75 / 80 |
heart | 80% | 702.75 | 685 / 861 | 0% | 0 | 0 / 0 |
muscle | 44% | 305.82 | 351 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0060271 | Biological process | cilium assembly |
GO_0043123 | Biological process | positive regulation of canonical NF-kappaB signal transduction |
GO_0002753 | Biological process | cytoplasmic pattern recognition receptor signaling pathway |
GO_0045087 | Biological process | innate immune response |
GO_0005813 | Cellular component | centrosome |
GO_0005929 | Cellular component | cilium |
GO_0005829 | Cellular component | cytosol |
GO_0000922 | Cellular component | spindle pole |
GO_0048029 | Molecular function | monosaccharide binding |
GO_0005524 | Molecular function | ATP binding |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | ALPK1 |
Protein name | Alpha-protein kinase 1 (EC 2.7.11.1) (Chromosome 4 kinase) (Lymphocyte alpha-protein kinase) Alpha kinase 1 (cDNA FLJ39927 fis, clone SPLEN2021194, highly similar to Homo sapiens alpha-kinase 1 (ALPK1), mRNA) Alpha kinase 1 Alpha kinase 1 (cDNA FLJ61015, highly similar to Homo sapiens alpha-kinase 1 (ALPK1), mRNA) Alternative protein ALPK1 |
Synonyms | KIAA1527 LAK |
Description | FUNCTION: Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity . Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria . ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering pro-inflammatory NF-kappa-B signaling . May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A . May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A . May play a role in ciliogenesis . . |
Accessions | ENST00000650871.1 [Q96QP1-1] L8E8U4 B3KUH8 ENST00000509722.5 B4E0R2 ENST00000505127.5 D6RB29 ENST00000458497.6 [Q96QP1-1] ENST00000515330.5 Q96QP1 ENST00000177648.13 [Q96QP1-1] ENST00000504176.6 [Q96QP1-2] |