ALPK1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ALPK1 at tissue level.

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0002753Biological processcytoplasmic pattern recognition receptor signaling pathway
GO_0045087Biological processinnate immune response
GO_0005813Cellular componentcentrosome
GO_0005929Cellular componentcilium
GO_0005829Cellular componentcytosol
GO_0000922Cellular componentspindle pole
GO_0048029Molecular functionmonosaccharide binding
GO_0005524Molecular functionATP binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameALPK1
Protein nameAlpha-protein kinase 1 (EC 2.7.11.1) (Chromosome 4 kinase) (Lymphocyte alpha-protein kinase)
Alpha kinase 1 (cDNA FLJ39927 fis, clone SPLEN2021194, highly similar to Homo sapiens alpha-kinase 1 (ALPK1), mRNA)
Alpha kinase 1
Alpha kinase 1 (cDNA FLJ61015, highly similar to Homo sapiens alpha-kinase 1 (ALPK1), mRNA)
Alternative protein ALPK1
SynonymsKIAA1527
LAK
DescriptionFUNCTION: Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity . Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria . ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering pro-inflammatory NF-kappa-B signaling . May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A . May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A . May play a role in ciliogenesis . .

AccessionsENST00000650871.1 [Q96QP1-1]
L8E8U4
B3KUH8
ENST00000509722.5
B4E0R2
ENST00000505127.5
D6RB29
ENST00000458497.6 [Q96QP1-1]
ENST00000515330.5
Q96QP1
ENST00000177648.13 [Q96QP1-1]
ENST00000504176.6 [Q96QP1-2]