ALOX5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1901753Biological processleukotriene A4 biosynthetic process
GO_0050796Biological processregulation of insulin secretion
GO_1904999Biological processpositive regulation of leukocyte adhesion to arterial endothelial cell
GO_0061045Biological processnegative regulation of wound healing
GO_0034440Biological processlipid oxidation
GO_0002540Biological processleukotriene production involved in inflammatory response
GO_0019372Biological processlipoxygenase pathway
GO_0019370Biological processleukotriene biosynthetic process
GO_0002523Biological processleukocyte migration involved in inflammatory response
GO_1903671Biological processnegative regulation of sprouting angiogenesis
GO_0050727Biological processregulation of inflammatory response
GO_1903573Biological processnegative regulation of response to endoplasmic reticulum stress
GO_0036336Biological processdendritic cell migration
GO_0006959Biological processhumoral immune response
GO_0016525Biological processnegative regulation of angiogenesis
GO_1903426Biological processregulation of reactive oxygen species biosynthetic process
GO_2001301Biological processlipoxin biosynthetic process
GO_0006691Biological processleukotriene metabolic process
GO_0001937Biological processnegative regulation of endothelial cell proliferation
GO_0050728Biological processnegative regulation of inflammatory response
GO_1900015Biological processregulation of cytokine production involved in inflammatory response
GO_1900407Biological processregulation of cellular response to oxidative stress
GO_0045598Biological processregulation of fat cell differentiation
GO_0042759Biological processlong-chain fatty acid biosynthetic process
GO_0002232Biological processleukocyte chemotaxis involved in inflammatory response
GO_0106014Biological processregulation of inflammatory response to wounding
GO_0019369Biological processarachidonic acid metabolic process
GO_0030501Biological processpositive regulation of bone mineralization
GO_0061044Biological processnegative regulation of vascular wound healing
GO_0042593Biological processglucose homeostasis
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005641Cellular componentnuclear envelope lumen
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005654Cellular componentnucleoplasm
GO_0005635Cellular componentnuclear envelope
GO_0034774Cellular componentsecretory granule lumen
GO_0016363Cellular componentnuclear matrix
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0005829Cellular componentcytosol
GO_0031965Cellular componentnuclear membrane
GO_0004051Molecular functionarachidonate 5-lipoxygenase activity
GO_0016787Molecular functionhydrolase activity
GO_0005506Molecular functioniron ion binding
GO_0036403Molecular functionarachidonate 8(S)-lipoxygenase activity
GO_0004052Molecular functionarachidonate 12(S)-lipoxygenase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameALOX5
Protein namePolyunsaturated fatty acid 5-lipoxygenase (EC 1.13.11.-) (Arachidonate 5-lipoxygenase) (5-LO) (5-lipoxygenase) (EC 1.13.11.34)
LOX-5 splice variant
Polyunsaturated fatty acid 5-lipoxygenase
SynonymsLOG5
DescriptionFUNCTION: Catalyzes the oxygenation of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) to 5-hydroperoxyeicosatetraenoate (5-HPETE) followed by the dehydration to 5,6- epoxyeicosatetraenoate (Leukotriene A4/LTA4), the first two steps in the biosynthesis of leukotrienes, which are potent mediators of inflammation . Also catalyzes the oxygenation of arachidonate into 8-hydroperoxyicosatetraenoate (8-HPETE) and 12-hydroperoxyicosatetraenoate (12-HPETE) . Displays lipoxin synthase activity being able to convert (15S)-HETE into a conjugate tetraene . Although arachidonate is the preferred substrate, this enzyme can also metabolize oxidized fatty acids derived from arachidonate such as (15S)-HETE, eicosapentaenoate (EPA) such as (18R)- and (18S)-HEPE or docosahexaenoate (DHA) which lead to the formation of specialized pro-resolving mediators (SPM) lipoxin and resolvins E and D respectively, therefore it participates in anti-inflammatory responses . Oxidation of DHA directly inhibits endothelial cell proliferation and sprouting angiogenesis via peroxisome proliferator-activated receptor gamma (PPARgamma) (By similarity). It does not catalyze the oxygenation of linoleic acid and does not convert (5S)-HETE to lipoxin isomers . In addition to inflammatory processes, it participates in dendritic cell migration, wound healing through an antioxidant mechanism based on heme oxygenase-1 (HO-1) regulation expression, monocyte adhesion to the endothelium via ITGAM expression on monocytes (By similarity). Moreover, it helps establish an adaptive humoral immunity by regulating primary resting B cells and follicular helper T cells and participates in the CD40-induced production of reactive oxygen species (ROS) after CD40 ligation in B cells through interaction with PIK3R1 that bridges ALOX5 with CD40 . May also play a role in glucose homeostasis, regulation of insulin secretion and palmitic acid-induced insulin resistance via AMPK (By similarity). Can regulate bone mineralization and fat cell differentiation increases in induced pluripotent stem cells (By similarity). .

AccessionsI0CLG0
ENST00000622021.4 [P09917-2]
ENST00000622238.1
ENST00000542434.5 [P09917-2]
ENST00000374391.7 [P09917-1]
ENST00000610656.4 [P09917-1]
P09917
A0A087X109