AKAP7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1901381Biological processpositive regulation of potassium ion transmembrane transport
GO_1902261Biological processpositive regulation of delayed rectifier potassium channel activity
GO_0050804Biological processmodulation of chemical synaptic transmission
GO_0006811Biological processmonoatomic ion transport
GO_0008150Biological processbiological_process
GO_0060306Biological processregulation of membrane repolarization
GO_0010738Biological processregulation of protein kinase A signaling
GO_0071320Biological processcellular response to cAMP
GO_0035556Biological processintracellular signal transduction
GO_0008104Biological processprotein localization
GO_0001508Biological processaction potential
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0032991Cellular componentprotein-containing complex
GO_0098686Cellular componenthippocampal mossy fiber to CA3 synapse
GO_0005829Cellular componentcytosol
GO_0016328Cellular componentlateral plasma membrane
GO_0005634Cellular componentnucleus
GO_0034237Molecular functionprotein kinase A regulatory subunit binding
GO_0019901Molecular functionprotein kinase binding
GO_0000166Molecular functionnucleotide binding
GO_0051018Molecular functionprotein kinase A binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAKAP7
Protein nameA-kinase anchor protein 7 isoform gamma (AKAP-7 isoform gamma) (A-kinase anchor protein 18 kDa) (AKAP 18) (Protein kinase A-anchoring protein 7 isoform gamma) (PRKA7 isoform gamma)
A kinase (PRKA) anchor protein 7
A kinase (PRKA) anchor protein 7 (A-kinase anchor protein 7 isoform alpha) (cDNA, FLJ92081, Homo sapiens A kinase (PRKA) anchor protein 7 (AKAP7), transcriptvariant alpha, mRNA)
A-kinase anchoring protein 7
A-kinase anchor protein 7 isoforms alpha and beta (AKAP-7 isoforms alpha and beta) (A-kinase anchor protein 18 kDa) (AKAP 18) (Protein kinase A-anchoring protein 7 isoforms alpha/beta) (PRKA7 isoforms alpha/beta)
SynonymshCG_20012
AKAP15
AKAP18
DescriptionFUNCTION: Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium. .

FUNCTION: Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium. .

AccessionsQ6P4D3
A0A9L9PYJ6
ENST00000537868.5
ENST00000683794.1
ENST00000263050.3
ENST00000474850.2 [O43687-1]
ENST00000706999.1
ENST00000431975.7 [Q9P0M2-1]
A0A804HI88
F5GXD1
ENST00000342266.4 [O43687-2]
Q2TAJ5
ENST00000541650.5
Q9P0M2
O43687
F5H4P9
J3KN37