I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| capillary endothelial cell | 4 studies | 30% ± 10% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| capillary endothelial cell | 4 studies | 30% ± 10% |
Insufficient scRNA-seq data for expression of ADRB1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 91% | 626.72 | 222 / 245 | 100% | 40.70 | 502 / 502 |
| brain | 81% | 580.05 | 2138 / 2642 | 92% | 4.99 | 652 / 705 |
| lung | 100% | 1801.25 | 576 / 578 | 60% | 3.06 | 696 / 1155 |
| intestine | 86% | 297.85 | 826 / 966 | 39% | 1.29 | 206 / 527 |
| esophagus | 61% | 209.99 | 879 / 1445 | 62% | 2.57 | 113 / 183 |
| heart | 99% | 1785.16 | 849 / 861 | 0% | 0 | 0 / 0 |
| bladder | 38% | 101.48 | 8 / 21 | 45% | 2.86 | 228 / 504 |
| spleen | 83% | 190.33 | 199 / 241 | 0% | 0 | 0 / 0 |
| breast | 59% | 292.30 | 270 / 459 | 21% | 1.58 | 238 / 1118 |
| adipose | 75% | 352.00 | 905 / 1204 | 0% | 0 | 0 / 0 |
| stomach | 23% | 32.92 | 83 / 359 | 36% | 1.38 | 104 / 286 |
| kidney | 47% | 95.40 | 42 / 89 | 10% | 0.96 | 89 / 901 |
| pancreas | 13% | 18.21 | 41 / 328 | 34% | 0.76 | 60 / 178 |
| thymus | 28% | 60.83 | 180 / 653 | 19% | 0.45 | 112 / 605 |
| uterus | 1% | 2.14 | 2 / 170 | 42% | 1.79 | 192 / 459 |
| tonsil | 0% | 0 | 0 / 0 | 33% | 1.21 | 15 / 45 |
| adrenal gland | 1% | 2.53 | 2 / 258 | 22% | 1.09 | 50 / 230 |
| skin | 7% | 11.21 | 135 / 1809 | 13% | 1.43 | 62 / 472 |
| liver | 10% | 65.05 | 22 / 226 | 11% | 0.22 | 43 / 406 |
| ovary | 1% | 1.54 | 1 / 180 | 17% | 0.39 | 71 / 430 |
| blood vessel | 12% | 30.84 | 154 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 7% | 0.21 | 2 / 29 |
| peripheral blood | 5% | 10.83 | 51 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.06 | 1 / 80 |
| muscle | 1% | 1.46 | 8 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0050873 | Biological process | brown fat cell differentiation |
| GO_0071880 | Biological process | adenylate cyclase-activating adrenergic receptor signaling pathway |
| GO_0002024 | Biological process | diet induced thermogenesis |
| GO_0043410 | Biological process | positive regulation of MAPK cascade |
| GO_0040015 | Biological process | negative regulation of multicellular organism growth |
| GO_0002025 | Biological process | norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure |
| GO_0001997 | Biological process | positive regulation of the force of heart contraction by epinephrine-norepinephrine |
| GO_0042596 | Biological process | fear response |
| GO_0009409 | Biological process | response to cold |
| GO_0031649 | Biological process | heat generation |
| GO_0120162 | Biological process | positive regulation of cold-induced thermogenesis |
| GO_0060078 | Biological process | regulation of postsynaptic membrane potential |
| GO_0045187 | Biological process | regulation of circadian sleep/wake cycle, sleep |
| GO_0001996 | Biological process | positive regulation of heart rate by epinephrine-norepinephrine |
| GO_0098992 | Cellular component | neuronal dense core vesicle |
| GO_0098685 | Cellular component | Schaffer collateral - CA1 synapse |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005769 | Cellular component | early endosome |
| GO_0099579 | Molecular function | G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential |
| GO_0004939 | Molecular function | beta-adrenergic receptor activity |
| GO_0030165 | Molecular function | PDZ domain binding |
| GO_0031694 | Molecular function | alpha-2A adrenergic receptor binding |
| GO_0004940 | Molecular function | beta1-adrenergic receptor activity |
| GO_0046982 | Molecular function | protein heterodimerization activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | ADRB1 |
| Protein name | Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (Beta-1 adrenoceptor) |
| Synonyms | B1AR ADRB1R |
| Description | FUNCTION: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. Involved in the regulation of sleep/wake behaviors . . |
| Accessions | ENST00000369295.4 P08588 |
