ACSL5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010747Biological processpositive regulation of long-chain fatty acid import across plasma membrane
GO_0001676Biological processlong-chain fatty acid metabolic process
GO_0035338Biological processlong-chain fatty-acyl-CoA biosynthetic process
GO_0005741Cellular componentmitochondrial outer membrane
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005783Cellular componentendoplasmic reticulum
GO_0016020Cellular componentmembrane
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005739Cellular componentmitochondrion
GO_0004467Molecular functionlong-chain fatty acid-CoA ligase activity
GO_0047676Molecular functionarachidonate-CoA ligase activity
GO_0090434Molecular functionoleoyl-CoA ligase activity
GO_0005515Molecular functionprotein binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameACSL5
Protein nameLong-chain-fatty-acid--CoA ligase 5 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 5) (LACS 5)
Arachidonate--CoA ligase (EC 6.2.1.15) (EC 6.2.1.3)
Acyl-CoA synthetase long chain family member 5
Long-chain-fatty-acid--CoA ligase (EC 6.2.1.15) (EC 6.2.1.3) (Acyl-CoA synthetase) (Long-chain acyl-CoA synthetase)
SynonymsACS5
UNQ633/PRO1250
FACL5
DescriptionFUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. .

FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation . ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells. .

AccessionsQ9ULC5
ENST00000495539.5
ENST00000433418.6
A0A8C8L3F5
ENST00000354273.5
A0A8C8KCK5
ENST00000356116.6 [Q9ULC5-3]
ENST00000354655.9 [Q9ULC5-1]
A0A804HIN9
ENST00000393081.6 [Q9ULC5-1]