ACSL4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060136Biological processembryonic process involved in female pregnancy
GO_0035336Biological processlong-chain fatty-acyl-CoA metabolic process
GO_0006631Biological processfatty acid metabolic process
GO_0032024Biological processpositive regulation of insulin secretion
GO_0030182Biological processneuron differentiation
GO_0001676Biological processlong-chain fatty acid metabolic process
GO_0006629Biological processlipid metabolic process
GO_0035338Biological processlong-chain fatty-acyl-CoA biosynthetic process
GO_0005778Cellular componentperoxisomal membrane
GO_0005886Cellular componentplasma membrane
GO_0005811Cellular componentlipid droplet
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0070062Cellular componentextracellular exosome
GO_0044233Cellular componentmitochondria-associated endoplasmic reticulum membrane contact site
GO_0005783Cellular componentendoplasmic reticulum
GO_0005737Cellular componentcytoplasm
GO_0005741Cellular componentmitochondrial outer membrane
GO_0031957Molecular functionvery long-chain fatty acid-CoA ligase activity
GO_0004467Molecular functionlong-chain fatty acid-CoA ligase activity
GO_0090433Molecular functionpalmitoyl-CoA ligase activity
GO_0047676Molecular functionarachidonate-CoA ligase activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameACSL4
Protein nameLong-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 4) (LACS 4)
long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)
Acyl-CoA synthetase long chain family member 4
SynonymsACS4
FACL4
LACS4
DescriptionFUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation . Preferentially activates arachidonate and eicosapentaenoate as substrates . Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion . .

AccessionsENST00000469796.7 [O60488-1]
ENST00000348502.10 [O60488-2]
ENST00000671846.1 [O60488-1]
D6RDA8
ENST00000502391.6 [O60488-1]
H0Y9A0
ENST00000682031.1
ENST00000340800.7 [O60488-1]
ENST00000672401.1 [O60488-2]
ENST00000505855.1
O60488
ENST00000508092.5
ENST00000514500.1
ENST00000672282.1 [O60488-2]
ENST00000673016.1 [O60488-2]
D6RF95
A0A804HI36