Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| mast cell | 28 studies | 50% ± 18% | |
| macrophage | 14 studies | 26% ± 12% | |
| fibroblast | 13 studies | 25% ± 10% | |
| classical monocyte | 13 studies | 23% ± 6% | |
| endothelial cell | 10 studies | 29% ± 11% | |
| type II pneumocyte | 10 studies | 36% ± 9% | |
| glutamatergic neuron | 10 studies | 36% ± 22% | |
| oligodendrocyte | 10 studies | 29% ± 10% | |
| monocyte | 9 studies | 29% ± 7% | |
| non-classical monocyte | 9 studies | 21% ± 6% | |
| microglial cell | 9 studies | 31% ± 11% | |
| oligodendrocyte precursor cell | 9 studies | 26% ± 13% | |
| adipocyte | 9 studies | 28% ± 15% | |
| dendritic cell | 7 studies | 26% ± 6% | |
| neuron | 6 studies | 35% ± 22% | |
| interneuron | 6 studies | 38% ± 24% | |
| kidney loop of Henle epithelial cell | 6 studies | 29% ± 8% | |
| myeloid cell | 6 studies | 32% ± 9% | |
| GABAergic neuron | 6 studies | 41% ± 20% | |
| kidney distal convoluted tubule epithelial cell | 5 studies | 52% ± 10% | |
| type I pneumocyte | 5 studies | 21% ± 3% | |
| conventional dendritic cell | 4 studies | 23% ± 8% | |
| epithelial cell | 4 studies | 40% ± 16% | |
| lymphocyte | 4 studies | 20% ± 5% | |
| astrocyte | 4 studies | 27% ± 6% | |
| brush cell | 4 studies | 37% ± 24% | |
| alveolar macrophage | 4 studies | 33% ± 10% | |
| basal cell | 4 studies | 23% ± 7% | |
| hematopoietic precursor cell | 3 studies | 22% ± 9% | |
| GABAergic interneuron | 3 studies | 25% ± 4% | |
| retinal ganglion cell | 3 studies | 22% ± 3% | |
| retinal bipolar neuron | 3 studies | 18% ± 2% | |
| mesothelial cell | 3 studies | 24% ± 1% | |
| mononuclear phagocyte | 3 studies | 20% ± 5% | |
| rod bipolar cell | 3 studies | 34% ± 7% | |
| granulocyte | 3 studies | 47% ± 1% | |
| megakaryocyte-erythroid progenitor cell | 3 studies | 30% ± 7% | |
| neutrophil | 3 studies | 20% ± 4% | |
| pericyte | 3 studies | 26% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 7424.79 | 577 / 578 | 99% | 46.48 | 1147 / 1155 |
| adrenal gland | 100% | 7877.76 | 258 / 258 | 99% | 58.92 | 228 / 230 |
| ovary | 100% | 3268.39 | 180 / 180 | 99% | 30.67 | 426 / 430 |
| esophagus | 98% | 2663.63 | 1421 / 1445 | 99% | 55.92 | 182 / 183 |
| kidney | 100% | 7043.16 | 89 / 89 | 98% | 41.78 | 879 / 901 |
| thymus | 100% | 2612.78 | 650 / 653 | 98% | 31.27 | 593 / 605 |
| brain | 95% | 2726.47 | 2520 / 2642 | 99% | 27.10 | 701 / 705 |
| intestine | 98% | 2652.08 | 950 / 966 | 96% | 34.42 | 506 / 527 |
| stomach | 97% | 2587.68 | 348 / 359 | 97% | 39.95 | 278 / 286 |
| bladder | 100% | 3186.76 | 21 / 21 | 93% | 31.10 | 470 / 504 |
| uterus | 99% | 2699.65 | 169 / 170 | 92% | 26.33 | 423 / 459 |
| skin | 98% | 3845.81 | 1775 / 1809 | 90% | 34.10 | 426 / 472 |
| breast | 100% | 4938.69 | 459 / 459 | 87% | 21.21 | 974 / 1118 |
| prostate | 98% | 2385.84 | 240 / 245 | 67% | 9.96 | 336 / 502 |
| pancreas | 58% | 783.99 | 190 / 328 | 98% | 36.98 | 174 / 178 |
| liver | 45% | 1079.34 | 102 / 226 | 85% | 124.29 | 345 / 406 |
| adipose | 100% | 7045.85 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 100% | 2954.34 | 241 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 4003.33 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 26.25 | 43 / 45 |
| muscle | 95% | 6401.62 | 764 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 93% | 38.10 | 27 / 29 |
| heart | 93% | 2925.40 | 798 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 92% | 6363.55 | 856 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 46% | 7.36 | 37 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0060136 | Biological process | embryonic process involved in female pregnancy |
| GO_0035336 | Biological process | long-chain fatty-acyl-CoA metabolic process |
| GO_0006631 | Biological process | fatty acid metabolic process |
| GO_0032024 | Biological process | positive regulation of insulin secretion |
| GO_0030182 | Biological process | neuron differentiation |
| GO_0001676 | Biological process | long-chain fatty acid metabolic process |
| GO_0006629 | Biological process | lipid metabolic process |
| GO_0035338 | Biological process | long-chain fatty-acyl-CoA biosynthetic process |
| GO_0005778 | Cellular component | peroxisomal membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005811 | Cellular component | lipid droplet |
| GO_0016020 | Cellular component | membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0044233 | Cellular component | mitochondria-associated endoplasmic reticulum membrane contact site |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005741 | Cellular component | mitochondrial outer membrane |
| GO_0031957 | Molecular function | very long-chain fatty acid-CoA ligase activity |
| GO_0004467 | Molecular function | long-chain fatty acid-CoA ligase activity |
| GO_0090433 | Molecular function | palmitoyl-CoA ligase activity |
| GO_0047676 | Molecular function | arachidonate-CoA ligase activity |
| GO_0005524 | Molecular function | ATP binding |
| Gene name | ACSL4 |
| Protein name | Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 4) (LACS 4) long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Acyl-CoA synthetase long chain family member 4 |
| Synonyms | ACS4 FACL4 LACS4 |
| Description | FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation . Preferentially activates arachidonate and eicosapentaenoate as substrates . Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion . . |
| Accessions | ENST00000469796.7 [O60488-1] ENST00000348502.10 [O60488-2] ENST00000671846.1 [O60488-1] D6RDA8 ENST00000502391.6 [O60488-1] H0Y9A0 ENST00000682031.1 ENST00000340800.7 [O60488-1] ENST00000672401.1 [O60488-2] ENST00000505855.1 O60488 ENST00000508092.5 ENST00000514500.1 ENST00000672282.1 [O60488-2] ENST00000673016.1 [O60488-2] D6RF95 A0A804HI36 |