ACSL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007584Biological processresponse to nutrient
GO_0034201Biological processresponse to oleic acid
GO_0033211Biological processadiponectin-activated signaling pathway
GO_0014070Biological processresponse to organic cyclic compound
GO_0008610Biological processlipid biosynthetic process
GO_0000038Biological processvery long-chain fatty acid metabolic process
GO_0015908Biological processfatty acid transport
GO_0042178Biological processxenobiotic catabolic process
GO_0019432Biological processtriglyceride biosynthetic process
GO_0044539Biological processlong-chain fatty acid import into cell
GO_0001676Biological processlong-chain fatty acid metabolic process
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0010747Biological processpositive regulation of long-chain fatty acid import across plasma membrane
GO_0035338Biological processlong-chain fatty-acyl-CoA biosynthetic process
GO_0005778Cellular componentperoxisomal membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005739Cellular componentmitochondrion
GO_0005783Cellular componentendoplasmic reticulum
GO_0005741Cellular componentmitochondrial outer membrane
GO_0004467Molecular functionlong-chain fatty acid-CoA ligase activity
GO_0090434Molecular functionoleoyl-CoA ligase activity
GO_0043539Molecular functionprotein serine/threonine kinase activator activity
GO_0070251Molecular functionpristanate-CoA ligase activity
GO_0047676Molecular functionarachidonate-CoA ligase activity
GO_0005524Molecular functionATP binding
GO_0050197Molecular functionphytanate-CoA ligase activity

IV. Literature review

[source]
Gene nameACSL1
Protein nameLong-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Acyl-CoA synthetase 1) (ACS1) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 1) (LACS 1) (Long-chain acyl-CoA synthetase 2) (LACS 2) (Long-chain fatty acid-CoA ligase 2) (Palmitoyl-CoA ligase 1) (Palmitoyl-CoA ligase 2) (Phytanate--CoA ligase) (EC 6.2.1.24)
Acyl-CoA synthetase long chain family member 1
long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)
Long-chain-fatty-acid--CoA ligase (EC 6.2.1.15) (EC 6.2.1.3) (Acyl-CoA synthetase) (Long-chain acyl-CoA synthetase)
SynonymsLACS1
FACL2
LACS
FACL1
LACS2
DescriptionFUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation . Preferentially uses palmitoleate, oleate and linoleate . Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs) (By similarity). .

FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. .

FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. .

FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. .

FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. .

AccessionsH0Y9Z9
ENST00000504900.5
P33121
ENST00000706368.1 [P33121-3]
H0Y9U7
ENST00000706366.1 [P33121-3]
B7Z3Z9
ENST00000503407.6 [P33121-2]
ENST00000503407.6
Q108N2
E7EPM6
ENST00000506733.5
ENST00000706369.1 [P33121-1]
ENST00000505492.2
D6RG07
ENST00000515030.5 [P33121-1]
ENST00000507295.5
ENST00000513317.5 [P33121-3]
ENST00000706370.1
Q108N1
ENST00000504342.5 [P33121-1]
ENST00000706367.1 [P33121-1]
A0A994J7S4
D6RER0
ENST00000281455.7 [P33121-1]
ENST00000454703.6