ACER1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ACER1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ACER1 at tissue level.

III. Associated gene sets

GO_0030148Biological processsphingolipid biosynthetic process
GO_0030216Biological processkeratinocyte differentiation
GO_0008544Biological processepidermis development
GO_0019216Biological processregulation of lipid metabolic process
GO_0010446Biological processresponse to alkaline pH
GO_0046514Biological processceramide catabolic process
GO_0071277Biological processcellular response to calcium ion
GO_0006665Biological processsphingolipid metabolic process
GO_0030149Biological processsphingolipid catabolic process
GO_0030154Biological processcell differentiation
GO_0046512Biological processsphingosine biosynthetic process
GO_0048733Biological processsebaceous gland development
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0017040Molecular functionN-acylsphingosine amidohydrolase activity
GO_0102121Molecular functionceramidase activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding
GO_0071633Molecular functiondihydroceramidase activity

IV. Literature review

[source]
Gene nameACER1
Protein nameAlkaline ceramidase 1 (AlkCDase 1) (Alkaline CDase 1) (EC 3.5.1.-) (EC 3.5.1.23) (Acylsphingosine deacylase 3) (N-acylsphingosine amidohydrolase 3)
SynonymsASAH3
DescriptionFUNCTION: Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH . Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation . Exhibits a strong substrate specificity towards the natural stereoisomer of ceramides with D-erythro-sphingosine as a backbone and has a higher activity towards very long-chain unsaturated fatty acids like the C24:1-ceramide . May also hydrolyze dihydroceramides to produce dihydrosphingosine . ACER1 is a skin-specific ceramidase that regulates the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes and more generally plays an important role in skin homeostasis . .

AccessionsENST00000301452.5
Q8TDN7