Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 13 studies | 38% ± 18% | |
oligodendrocyte | 11 studies | 38% ± 16% | |
endothelial cell | 11 studies | 34% ± 18% | |
oligodendrocyte precursor cell | 10 studies | 39% ± 18% | |
adipocyte | 10 studies | 52% ± 22% | |
glutamatergic neuron | 9 studies | 51% ± 22% | |
GABAergic neuron | 8 studies | 46% ± 24% | |
epithelial cell | 8 studies | 36% ± 21% | |
fibroblast | 8 studies | 27% ± 9% | |
macrophage | 6 studies | 29% ± 13% | |
microglial cell | 6 studies | 28% ± 8% | |
ciliated cell | 6 studies | 24% ± 7% | |
endothelial cell of lymphatic vessel | 6 studies | 25% ± 11% | |
smooth muscle cell | 6 studies | 19% ± 2% | |
neuron | 5 studies | 47% ± 20% | |
interneuron | 5 studies | 64% ± 25% | |
retinal ganglion cell | 5 studies | 46% ± 20% | |
type I pneumocyte | 5 studies | 38% ± 12% | |
type II pneumocyte | 5 studies | 56% ± 14% | |
granule cell | 4 studies | 40% ± 12% | |
pericyte | 4 studies | 34% ± 15% | |
cardiac muscle cell | 4 studies | 21% ± 2% | |
Mueller cell | 4 studies | 29% ± 7% | |
retina horizontal cell | 4 studies | 34% ± 10% | |
retinal cone cell | 4 studies | 35% ± 12% | |
retinal rod cell | 4 studies | 21% ± 3% | |
respiratory goblet cell | 4 studies | 35% ± 19% | |
club cell | 4 studies | 49% ± 13% | |
basal cell | 4 studies | 44% ± 22% | |
progenitor cell | 3 studies | 33% ± 5% | |
mesothelial cell | 3 studies | 26% ± 5% | |
GABAergic amacrine cell | 3 studies | 25% ± 7% | |
OFF-bipolar cell | 3 studies | 27% ± 4% | |
ON-bipolar cell | 3 studies | 27% ± 2% | |
amacrine cell | 3 studies | 29% ± 11% | |
glycinergic amacrine cell | 3 studies | 21% ± 2% | |
retinal pigment epithelial cell | 3 studies | 49% ± 12% | |
abnormal cell | 3 studies | 33% ± 20% | |
goblet cell | 3 studies | 43% ± 32% | |
transit amplifying cell | 3 studies | 44% ± 32% | |
mucus secreting cell | 3 studies | 35% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 5579.17 | 1445 / 1445 | 100% | 33.73 | 183 / 183 |
prostate | 100% | 7049.14 | 245 / 245 | 100% | 85.15 | 502 / 502 |
brain | 100% | 5477.35 | 2641 / 2642 | 100% | 32.99 | 704 / 705 |
breast | 100% | 4599.05 | 459 / 459 | 99% | 36.98 | 1112 / 1118 |
uterus | 100% | 3614.75 | 170 / 170 | 99% | 23.56 | 456 / 459 |
bladder | 100% | 5934.86 | 21 / 21 | 99% | 22.43 | 499 / 504 |
lung | 100% | 3960.82 | 576 / 578 | 99% | 25.38 | 1145 / 1155 |
stomach | 99% | 2745.76 | 357 / 359 | 99% | 21.68 | 284 / 286 |
intestine | 100% | 3667.65 | 966 / 966 | 99% | 20.65 | 520 / 527 |
skin | 100% | 4298.30 | 1807 / 1809 | 98% | 18.76 | 461 / 472 |
thymus | 100% | 2788.93 | 652 / 653 | 93% | 10.85 | 561 / 605 |
pancreas | 94% | 1431.15 | 309 / 328 | 98% | 15.17 | 175 / 178 |
ovary | 100% | 3266.92 | 180 / 180 | 91% | 12.72 | 392 / 430 |
adrenal gland | 100% | 7059.49 | 258 / 258 | 86% | 12.10 | 198 / 230 |
kidney | 99% | 1965.25 | 88 / 89 | 83% | 9.14 | 751 / 901 |
liver | 100% | 3016.31 | 226 / 226 | 81% | 10.83 | 329 / 406 |
adipose | 100% | 4384.10 | 1204 / 1204 | 0% | 0 | 0 / 0 |
spleen | 100% | 1976.18 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 8.14 | 1 / 1 |
blood vessel | 100% | 3006.92 | 1331 / 1335 | 0% | 0 | 0 / 0 |
muscle | 99% | 2794.31 | 796 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 24.60 | 44 / 45 |
heart | 89% | 1463.48 | 766 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 89% | 12.26 | 71 / 80 |
lymph node | 0% | 0 | 0 / 0 | 66% | 6.72 | 19 / 29 |
peripheral blood | 25% | 932.54 | 229 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0071380 | Biological process | cellular response to prostaglandin E stimulus |
GO_0019538 | Biological process | protein metabolic process |
GO_0006633 | Biological process | fatty acid biosynthetic process |
GO_0055088 | Biological process | lipid homeostasis |
GO_0001894 | Biological process | tissue homeostasis |
GO_0006084 | Biological process | acetyl-CoA metabolic process |
GO_0046949 | Biological process | fatty-acyl-CoA biosynthetic process |
GO_2001295 | Biological process | malonyl-CoA biosynthetic process |
GO_0051289 | Biological process | protein homotetramerization |
GO_0015629 | Cellular component | actin cytoskeleton |
GO_0001650 | Cellular component | fibrillar center |
GO_0005829 | Cellular component | cytosol |
GO_0005739 | Cellular component | mitochondrion |
GO_0003989 | Molecular function | acetyl-CoA carboxylase activity |
GO_0042802 | Molecular function | identical protein binding |
GO_0005515 | Molecular function | protein binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0005524 | Molecular function | ATP binding |
Gene name | ACACA |
Protein name | Alternative protein ACACA ACACA protein Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha) Acetyl-CoA carboxylase 1 (Acetyl-CoA carboxylase alpha) Acetyl-CoA carboxylase 1 (Acetyl-CoA carboxylase alpha) (Acetyl-Coenzyme A carboxylase alpha isoform 2 variant) |
Synonyms | ACAC ACC1 ACCA |
Description | FUNCTION: Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis . This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA . . |
Accessions | ENST00000613687.4 [Q13085-1] ENST00000617649.4 [Q13085-3] ENST00000631953.1 ENST00000632723.1 ENST00000633050.1 A0A087WYK6 A0A0C4DGT1 ENST00000633325.1 ENST00000615229.4 A0A087WYS8 ENST00000616317.5 [Q13085-4] L8EAV0 ENST00000632453.1 ENST00000612895.4 [Q13085-2] ENST00000614789.4 ENST00000632361.1 A0A087WVR6 ENST00000632486.1 ENST00000616352.4 ENST00000614428.4 [Q13085-1] Q7Z5W8 ENST00000618053.1 ENST00000621312.4 [Q13085-3] ENST00000612007.1 ENST00000619487.4 [Q13085-4] ENST00000634140.1 A0A087X0W4 ENST00000614482.4 ENST00000619546.4 Q13085 A0A087X126 ENST00000611803.2 [Q13085-2] ENST00000621960.1 A0A087WWN5 ENST00000631657.1 ENST00000615918.2 Q59FY4 ENST00000617548.1 ENST00000614438.1 A0A087X2F8 |