ACACA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071380Biological processcellular response to prostaglandin E stimulus
GO_0019538Biological processprotein metabolic process
GO_0006633Biological processfatty acid biosynthetic process
GO_0055088Biological processlipid homeostasis
GO_0001894Biological processtissue homeostasis
GO_0006084Biological processacetyl-CoA metabolic process
GO_0046949Biological processfatty-acyl-CoA biosynthetic process
GO_2001295Biological processmalonyl-CoA biosynthetic process
GO_0051289Biological processprotein homotetramerization
GO_0015629Cellular componentactin cytoskeleton
GO_0001650Cellular componentfibrillar center
GO_0005829Cellular componentcytosol
GO_0005739Cellular componentmitochondrion
GO_0003989Molecular functionacetyl-CoA carboxylase activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameACACA
Protein nameAlternative protein ACACA
ACACA protein
Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha)
Acetyl-CoA carboxylase 1 (Acetyl-CoA carboxylase alpha)
Acetyl-CoA carboxylase 1 (Acetyl-CoA carboxylase alpha) (Acetyl-Coenzyme A carboxylase alpha isoform 2 variant)
SynonymsACAC
ACC1
ACCA
DescriptionFUNCTION: Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis . This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA . .

AccessionsENST00000613687.4 [Q13085-1]
ENST00000617649.4 [Q13085-3]
ENST00000631953.1
ENST00000632723.1
ENST00000633050.1
A0A087WYK6
A0A0C4DGT1
ENST00000633325.1
ENST00000615229.4
A0A087WYS8
ENST00000616317.5 [Q13085-4]
L8EAV0
ENST00000632453.1
ENST00000612895.4 [Q13085-2]
ENST00000614789.4
ENST00000632361.1
A0A087WVR6
ENST00000632486.1
ENST00000616352.4
ENST00000614428.4 [Q13085-1]
Q7Z5W8
ENST00000618053.1
ENST00000621312.4 [Q13085-3]
ENST00000612007.1
ENST00000619487.4 [Q13085-4]
ENST00000634140.1
A0A087X0W4
ENST00000614482.4
ENST00000619546.4
Q13085
A0A087X126
ENST00000611803.2 [Q13085-2]
ENST00000621960.1
A0A087WWN5
ENST00000631657.1
ENST00000615918.2
Q59FY4
ENST00000617548.1
ENST00000614438.1
A0A087X2F8