ZSCAN4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ZSCAN4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ZSCAN4 at tissue level.

III. Associated gene sets

GO_0045950Biological processnegative regulation of mitotic recombination
GO_0010833Biological processtelomere maintenance via telomere lengthening
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000781Cellular componentchromosome, telomeric region
GO_0005634Cellular componentnucleus
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0005515Molecular functionprotein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameZSCAN4
Protein nameZinc finger and SCAN domain-containing protein 4 (Zinc finger protein 494)
SynonymsZNF494
DescriptionFUNCTION: Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity). .

AccessionsQ8NAM6
ENST00000318203.9