Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 10 studies | 22% ± 7% | |
astrocyte | 6 studies | 34% ± 13% | |
microglial cell | 5 studies | 23% ± 4% | |
oligodendrocyte | 5 studies | 23% ± 4% | |
macrophage | 5 studies | 18% ± 3% | |
neuron | 4 studies | 22% ± 7% | |
epithelial cell | 4 studies | 32% ± 11% | |
adipocyte | 4 studies | 21% ± 4% | |
fibroblast | 4 studies | 18% ± 4% | |
lymphocyte | 3 studies | 16% ± 1% | |
GABAergic neuron | 3 studies | 51% ± 6% | |
glutamatergic neuron | 3 studies | 63% ± 10% | |
oligodendrocyte precursor cell | 3 studies | 26% ± 1% | |
endothelial cell of lymphatic vessel | 3 studies | 20% ± 3% | |
interneuron | 3 studies | 39% ± 19% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 4 studies | 46% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 1320.84 | 1445 / 1445 | 100% | 9.80 | 183 / 183 |
intestine | 100% | 1415.32 | 966 / 966 | 99% | 6.05 | 520 / 527 |
lung | 100% | 1454.36 | 577 / 578 | 98% | 7.44 | 1136 / 1155 |
breast | 100% | 1388.27 | 459 / 459 | 98% | 11.63 | 1096 / 1118 |
stomach | 100% | 962.98 | 359 / 359 | 98% | 6.83 | 279 / 286 |
brain | 99% | 1160.04 | 2623 / 2642 | 98% | 11.07 | 690 / 705 |
prostate | 100% | 1106.69 | 245 / 245 | 94% | 8.61 | 471 / 502 |
skin | 100% | 1946.35 | 1808 / 1809 | 93% | 6.85 | 440 / 472 |
bladder | 100% | 1307.33 | 21 / 21 | 92% | 5.78 | 465 / 504 |
thymus | 100% | 1071.89 | 651 / 653 | 92% | 8.14 | 557 / 605 |
pancreas | 96% | 557.73 | 316 / 328 | 95% | 6.89 | 169 / 178 |
ovary | 100% | 1950.63 | 180 / 180 | 91% | 7.14 | 392 / 430 |
uterus | 100% | 1738.75 | 170 / 170 | 91% | 7.69 | 418 / 459 |
kidney | 100% | 668.40 | 89 / 89 | 88% | 6.00 | 792 / 901 |
adrenal gland | 100% | 2173.44 | 258 / 258 | 87% | 6.51 | 199 / 230 |
liver | 100% | 764.74 | 226 / 226 | 84% | 5.74 | 340 / 406 |
adipose | 100% | 1504.26 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1763.31 | 1335 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 3917.66 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 818.08 | 241 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 95% | 745.43 | 881 / 929 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 93% | 7.44 | 42 / 45 |
heart | 93% | 1120.62 | 802 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 93% | 7.43 | 74 / 80 |
lymph node | 0% | 0 | 0 / 0 | 59% | 3.56 | 17 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0035523 | Biological process | protein K29-linked deubiquitination |
GO_0022604 | Biological process | regulation of cell morphogenesis |
GO_1990168 | Biological process | protein K33-linked deubiquitination |
GO_0071947 | Biological process | protein deubiquitination involved in ubiquitin-dependent protein catabolic process |
GO_0007010 | Biological process | cytoskeleton organization |
GO_0070536 | Biological process | protein K63-linked deubiquitination |
GO_0016055 | Biological process | Wnt signaling pathway |
GO_0030177 | Biological process | positive regulation of Wnt signaling pathway |
GO_0016477 | Biological process | cell migration |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0005634 | Cellular component | nucleus |
GO_0101005 | Molecular function | deubiquitinase activity |
GO_0070530 | Molecular function | K63-linked polyubiquitin modification-dependent protein binding |
GO_0004843 | Molecular function | cysteine-type deubiquitinase activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0031593 | Molecular function | polyubiquitin modification-dependent protein binding |
GO_0005515 | Molecular function | protein binding |
Gene name | ZRANB1 |
Protein name | Ubiquitin thioesterase ZRANB1 (EC 3.4.19.12) (TRAF-binding domain-containing protein) (hTrabid) (Zinc finger Ran-binding domain-containing protein 1) |
Synonyms | TRABID |
Description | FUNCTION: Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin . Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones . Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription . Acts as a regulator of autophagy by mediating deubiquitination of PIK3C3/VPS34, thereby promoting autophagosome maturation . Plays a role in the regulation of cell morphology and cytoskeletal organization . Required in the stress fiber dynamics and cell migration . . |
Accessions | Q9UGI0 ENST00000359653.4 |