ZRANB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035523Biological processprotein K29-linked deubiquitination
GO_0022604Biological processregulation of cell morphogenesis
GO_1990168Biological processprotein K33-linked deubiquitination
GO_0071947Biological processprotein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO_0007010Biological processcytoskeleton organization
GO_0070536Biological processprotein K63-linked deubiquitination
GO_0016055Biological processWnt signaling pathway
GO_0030177Biological processpositive regulation of Wnt signaling pathway
GO_0016477Biological processcell migration
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005634Cellular componentnucleus
GO_0101005Molecular functiondeubiquitinase activity
GO_0070530Molecular functionK63-linked polyubiquitin modification-dependent protein binding
GO_0004843Molecular functioncysteine-type deubiquitinase activity
GO_0046872Molecular functionmetal ion binding
GO_0031593Molecular functionpolyubiquitin modification-dependent protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameZRANB1
Protein nameUbiquitin thioesterase ZRANB1 (EC 3.4.19.12) (TRAF-binding domain-containing protein) (hTrabid) (Zinc finger Ran-binding domain-containing protein 1)
SynonymsTRABID
DescriptionFUNCTION: Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin . Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones . Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription . Acts as a regulator of autophagy by mediating deubiquitination of PIK3C3/VPS34, thereby promoting autophagosome maturation . Plays a role in the regulation of cell morphology and cytoskeletal organization . Required in the stress fiber dynamics and cell migration . .

AccessionsQ9UGI0
ENST00000359653.4