ZNG1E report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051604Biological processprotein maturation
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005525Molecular functionGTP binding
GO_0140827Molecular functionzinc chaperone activity
GO_0046872Molecular functionmetal ion binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameZNG1E
Protein nameZn regulated GTPase metalloprotein activator 1E
COBW domain-containing protein 5
Zinc-regulated GTPase metalloprotein activator 1E (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 5) (COBW domain-containing protein 5)
CBWD5 protein (Zn regulated GTPase metalloprotein activator 1E)
CBWD5 protein
Zn regulated GTPase metalloprotein activator 1C (Zn regulated GTPase metalloprotein activator 1E) (Zn regulated GTPase metalloprotein activator 1F)
SynonymsCBWD5
ZNG1F
ZNG1C
DescriptionFUNCTION: Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1E to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1. .

AccessionsENST00000430059.6
Q5RIB0
Q6NVZ8
ENST00000377395.8 [Q5RIA9-3]
ENST00000494538.6
ENST00000489273.1
ENST00000429800
ENST00000382405.8 [Q5RIA9-1]
ENST00000480229.5
E7EUZ7
H0Y857
ENST00000486221.5
ENST00000476161.5
ENST00000377344.6
Q5RIB3
A0A0A6YYH9
ENST00000497250.5
Q5JTY2
Q5RIA9
Q5JTY1
ENST00000377392.9