Name | Number of supported studies | Average coverage | |
---|---|---|---|
glutamatergic neuron | 7 studies | 40% ± 22% | |
GABAergic neuron | 6 studies | 36% ± 19% | |
microglial cell | 6 studies | 25% ± 6% | |
oligodendrocyte precursor cell | 6 studies | 22% ± 8% | |
B cell | 4 studies | 20% ± 3% | |
endothelial cell | 4 studies | 23% ± 8% | |
epithelial cell | 4 studies | 37% ± 19% | |
luminal hormone-sensing cell of mammary gland | 4 studies | 17% ± 2% | |
plasma cell | 3 studies | 26% ± 12% | |
plasmablast | 3 studies | 47% ± 20% | |
classical monocyte | 3 studies | 19% ± 4% | |
type II pneumocyte | 3 studies | 23% ± 8% | |
dendritic cell | 3 studies | 21% ± 2% | |
basal cell | 3 studies | 27% ± 8% | |
oligodendrocyte | 3 studies | 23% ± 10% | |
interneuron | 3 studies | 50% ± 25% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 8 studies | 33% ± 19% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 298.26 | 1443 / 1445 | 87% | 1.99 | 159 / 183 |
breast | 100% | 580.14 | 458 / 459 | 87% | 2.57 | 970 / 1118 |
uterus | 100% | 311.81 | 170 / 170 | 74% | 1.30 | 340 / 459 |
ovary | 100% | 334.19 | 180 / 180 | 70% | 1.20 | 302 / 430 |
stomach | 100% | 224.05 | 358 / 359 | 67% | 1.18 | 192 / 286 |
bladder | 100% | 308.67 | 21 / 21 | 61% | 1.05 | 305 / 504 |
intestine | 100% | 314.43 | 965 / 966 | 57% | 0.99 | 303 / 527 |
lung | 99% | 312.78 | 575 / 578 | 54% | 0.95 | 625 / 1155 |
brain | 100% | 412.98 | 2630 / 2642 | 53% | 0.78 | 372 / 705 |
pancreas | 100% | 286.20 | 328 / 328 | 49% | 0.74 | 88 / 178 |
thymus | 100% | 470.85 | 652 / 653 | 44% | 0.62 | 268 / 605 |
adrenal gland | 100% | 288.85 | 257 / 258 | 41% | 0.56 | 95 / 230 |
prostate | 100% | 380.95 | 245 / 245 | 35% | 0.47 | 174 / 502 |
kidney | 100% | 351.38 | 89 / 89 | 34% | 0.51 | 310 / 901 |
liver | 100% | 435.75 | 225 / 226 | 28% | 0.39 | 112 / 406 |
skin | 100% | 397.16 | 1804 / 1809 | 23% | 0.32 | 110 / 472 |
spleen | 100% | 412.46 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 1.01 | 1 / 1 |
adipose | 100% | 288.97 | 1203 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 279.64 | 1330 / 1335 | 0% | 0 | 0 / 0 |
heart | 96% | 175.98 | 823 / 861 | 0% | 0 | 0 / 0 |
muscle | 93% | 130.33 | 748 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 81% | 227.89 | 754 / 929 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 66% | 1.30 | 19 / 29 |
tonsil | 0% | 0 | 0 / 0 | 56% | 0.86 | 25 / 45 |
eye | 0% | 0 | 0 / 0 | 4% | 0.04 | 3 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0051604 | Biological process | protein maturation |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0005525 | Molecular function | GTP binding |
GO_0140827 | Molecular function | zinc chaperone activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0003924 | Molecular function | GTPase activity |
Gene name | ZNG1E |
Protein name | Zn regulated GTPase metalloprotein activator 1E COBW domain-containing protein 5 Zinc-regulated GTPase metalloprotein activator 1E (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 5) (COBW domain-containing protein 5) CBWD5 protein (Zn regulated GTPase metalloprotein activator 1E) CBWD5 protein Zn regulated GTPase metalloprotein activator 1C (Zn regulated GTPase metalloprotein activator 1E) (Zn regulated GTPase metalloprotein activator 1F) |
Synonyms | CBWD5 ZNG1F ZNG1C |
Description | FUNCTION: Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1E to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1. . |
Accessions | ENST00000430059.6 Q5RIB0 Q6NVZ8 ENST00000377395.8 [Q5RIA9-3] ENST00000494538.6 ENST00000489273.1 ENST00000429800 ENST00000382405.8 [Q5RIA9-1] ENST00000480229.5 E7EUZ7 H0Y857 ENST00000486221.5 ENST00000476161.5 ENST00000377344.6 Q5RIB3 A0A0A6YYH9 ENST00000497250.5 Q5JTY2 Q5RIA9 Q5JTY1 ENST00000377392.9 |