Name | Number of supported studies | Average coverage | |
---|---|---|---|
epithelial cell | 5 studies | 35% ± 19% | |
endothelial cell | 4 studies | 19% ± 4% | |
retinal cone cell | 4 studies | 32% ± 11% | |
microglial cell | 4 studies | 21% ± 2% | |
plasma cell | 3 studies | 27% ± 14% | |
non-classical monocyte | 3 studies | 22% ± 7% | |
classical monocyte | 3 studies | 18% ± 2% | |
epithelial cell of proximal tubule | 3 studies | 17% ± 2% | |
myeloid cell | 3 studies | 23% ± 8% | |
retinal rod cell | 3 studies | 21% ± 5% | |
fibroblast | 3 studies | 19% ± 4% | |
ciliated cell | 3 studies | 28% ± 10% | |
macrophage | 3 studies | 18% ± 2% | |
GABAergic neuron | 3 studies | 30% ± 4% | |
glutamatergic neuron | 3 studies | 36% ± 5% | |
dendritic cell | 3 studies | 26% ± 6% | |
basal cell | 3 studies | 23% ± 5% | |
transit amplifying cell | 3 studies | 21% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 867.36 | 459 / 459 | 99% | 3.77 | 1104 / 1118 |
prostate | 100% | 837.00 | 245 / 245 | 98% | 3.10 | 494 / 502 |
thymus | 100% | 912.79 | 653 / 653 | 98% | 2.91 | 595 / 605 |
ovary | 100% | 641.14 | 180 / 180 | 95% | 2.82 | 407 / 430 |
esophagus | 100% | 881.57 | 1445 / 1445 | 95% | 2.74 | 173 / 183 |
uterus | 100% | 605.30 | 170 / 170 | 94% | 2.56 | 433 / 459 |
kidney | 100% | 988.13 | 89 / 89 | 94% | 2.39 | 848 / 901 |
bladder | 100% | 621.14 | 21 / 21 | 94% | 2.27 | 472 / 504 |
intestine | 100% | 622.24 | 965 / 966 | 92% | 2.40 | 483 / 527 |
stomach | 100% | 569.54 | 359 / 359 | 91% | 2.42 | 260 / 286 |
adrenal gland | 100% | 1058.00 | 258 / 258 | 90% | 2.37 | 207 / 230 |
lung | 100% | 646.69 | 577 / 578 | 90% | 2.04 | 1039 / 1155 |
pancreas | 100% | 665.43 | 328 / 328 | 89% | 1.64 | 158 / 178 |
brain | 99% | 453.13 | 2605 / 2642 | 90% | 1.78 | 631 / 705 |
skin | 100% | 858.60 | 1807 / 1809 | 68% | 1.21 | 322 / 472 |
liver | 99% | 381.03 | 223 / 226 | 68% | 1.15 | 276 / 406 |
adipose | 100% | 704.18 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 3.06 | 29 / 29 |
spleen | 100% | 655.43 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 2.54 | 1 / 1 |
blood vessel | 100% | 675.29 | 1333 / 1335 | 0% | 0 | 0 / 0 |
muscle | 99% | 491.03 | 796 / 803 | 0% | 0 | 0 / 0 |
heart | 96% | 510.26 | 828 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 2.80 | 43 / 45 |
peripheral blood | 65% | 324.69 | 600 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 55% | 0.99 | 44 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0001822 | Biological process | kidney development |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0005525 | Molecular function | GTP binding |
GO_0016787 | Molecular function | hydrolase activity |
GO_0005515 | Molecular function | protein binding |
GO_0046872 | Molecular function | metal ion binding |
Gene name | ZNG1A |
Protein name | Zinc-regulated GTPase metalloprotein activator 1A (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 1) (COBW domain-containing protein 1) (NPC-A-6 COBW domain-containing protein 1) (NPC-A-6) Zn regulated GTPase metalloprotein activator 1A |
Synonyms | CBWD1 |
Description | FUNCTION: Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1A to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1. . |
Accessions | ENST00000356521.9 [Q9BRT8-1] ENST00000619157.4 A0A087WZQ3 ENST00000377447.7 ENST00000612045.4 ENST00000382393.2 [Q9BRT8-4] A0A087X0Y9 A0A087WTC0 ENST00000616944.4 ENST00000489272.5 F2Z2T4 ENST00000382389.5 A0A087WVU7 ENST00000618061.4 ENST00000465014.6 A0A087WU37 ENST00000613355.4 ENST00000377400.8 [Q9BRT8-1] A0A087X1Y1 ENST00000616803.4 ENST00000618361.4 ENST00000314367.14 [Q9BRT8-2] A0A087X140 ENST00000613508.4 A0A087WY70 A0A0B4J1T6 Q9BRT8 ENST00000475990.5 ENST00000382447.8 [Q9BRT8-3] A0A087WWK6 |