ZNG1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001822Biological processkidney development
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005525Molecular functionGTP binding
GO_0016787Molecular functionhydrolase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameZNG1A
Protein nameZinc-regulated GTPase metalloprotein activator 1A (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 1) (COBW domain-containing protein 1) (NPC-A-6 COBW domain-containing protein 1) (NPC-A-6)
Zn regulated GTPase metalloprotein activator 1A
SynonymsCBWD1
DescriptionFUNCTION: Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1A to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1. .

AccessionsENST00000356521.9 [Q9BRT8-1]
ENST00000619157.4
A0A087WZQ3
ENST00000377447.7
ENST00000612045.4
ENST00000382393.2 [Q9BRT8-4]
A0A087X0Y9
A0A087WTC0
ENST00000616944.4
ENST00000489272.5
F2Z2T4
ENST00000382389.5
A0A087WVU7
ENST00000618061.4
ENST00000465014.6
A0A087WU37
ENST00000613355.4
ENST00000377400.8 [Q9BRT8-1]
A0A087X1Y1
ENST00000616803.4
ENST00000618361.4
ENST00000314367.14 [Q9BRT8-2]
A0A087X140
ENST00000613508.4
A0A087WY70
A0A0B4J1T6
Q9BRT8
ENST00000475990.5
ENST00000382447.8 [Q9BRT8-3]
A0A087WWK6