Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 14 studies | 22% ± 6% | |
| ciliated cell | 5 studies | 21% ± 3% | |
| monocyte | 5 studies | 20% ± 6% | |
| CD8-positive, alpha-beta T cell | 4 studies | 17% ± 1% | |
| myeloid cell | 4 studies | 26% ± 6% | |
| abnormal cell | 4 studies | 20% ± 2% | |
| CD4-positive, alpha-beta memory T cell | 3 studies | 16% ± 0% | |
| CD8-positive, alpha-beta memory T cell | 3 studies | 18% ± 1% | |
| respiratory goblet cell | 3 studies | 26% ± 10% | |
| epithelial cell | 3 studies | 31% ± 6% | |
| regulatory T cell | 3 studies | 16% ± 1% | |
| GABAergic neuron | 3 studies | 26% ± 4% | |
| glutamatergic neuron | 3 studies | 32% ± 5% | |
| dendritic cell | 3 studies | 25% ± 8% | |
| non-classical monocyte | 3 studies | 23% ± 10% | |
| alveolar macrophage | 3 studies | 20% ± 6% | |
| macrophage | 3 studies | 21% ± 4% | |
| astrocyte | 3 studies | 21% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 5 studies | 24% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 3724.12 | 1445 / 1445 | 100% | 55.92 | 183 / 183 |
| intestine | 100% | 4010.47 | 966 / 966 | 100% | 34.97 | 527 / 527 |
| stomach | 100% | 2977.40 | 359 / 359 | 100% | 42.96 | 286 / 286 |
| breast | 100% | 4734.41 | 459 / 459 | 100% | 45.83 | 1117 / 1118 |
| thymus | 100% | 5148.93 | 653 / 653 | 100% | 32.81 | 604 / 605 |
| uterus | 100% | 3906.88 | 170 / 170 | 100% | 27.94 | 458 / 459 |
| lung | 100% | 6810.59 | 578 / 578 | 100% | 34.00 | 1151 / 1155 |
| skin | 100% | 4559.32 | 1809 / 1809 | 100% | 35.60 | 470 / 472 |
| brain | 99% | 2327.96 | 2628 / 2642 | 100% | 30.82 | 705 / 705 |
| bladder | 100% | 3813.19 | 21 / 21 | 99% | 28.25 | 501 / 504 |
| ovary | 100% | 3072.62 | 180 / 180 | 99% | 35.92 | 426 / 430 |
| prostate | 100% | 3715.51 | 245 / 245 | 99% | 21.76 | 496 / 502 |
| kidney | 100% | 3189.16 | 89 / 89 | 99% | 30.20 | 888 / 901 |
| adrenal gland | 100% | 3247.38 | 258 / 258 | 93% | 17.34 | 215 / 230 |
| pancreas | 91% | 1307.22 | 297 / 328 | 98% | 35.67 | 175 / 178 |
| liver | 97% | 1595.31 | 220 / 226 | 85% | 13.33 | 347 / 406 |
| adipose | 100% | 5442.68 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 5580.98 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 21.29 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 35.72 | 29 / 29 |
| muscle | 100% | 3222.08 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 5768.52 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 33.02 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 7.85 | 1 / 1 |
| heart | 100% | 2690.75 | 857 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 99% | 6507.82 | 920 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0051607 | Biological process | defense response to virus |
| GO_0031048 | Biological process | regulatory ncRNA-mediated heterochromatin formation |
| GO_0045071 | Biological process | negative regulation of viral genome replication |
| GO_0042742 | Biological process | defense response to bacterium |
| GO_0045087 | Biological process | innate immune response |
| GO_0002218 | Biological process | activation of innate immune response |
| GO_0005741 | Cellular component | mitochondrial outer membrane |
| GO_0031380 | Cellular component | nuclear RNA-directed RNA polymerase complex |
| GO_0010494 | Cellular component | cytoplasmic stress granule |
| GO_0004386 | Molecular function | helicase activity |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0003723 | Molecular function | RNA binding |
| Gene name | ZNFX1 |
| Protein name | Zinc finger NFX1-type containing 1 NFX1-type zinc finger-containing protein 1 ZNFX1 protein |
| Synonyms | KIAA1404 |
| Description | FUNCTION: RNA-binding protein that initiates the antiviral response and is required to restrict the replication of RNA viruses . Acts as a double-stranded RNA (dsRNA) sensor that recognizes viral RNA and then interacts with MAVS to initiate the type I interferon response (By similarity). Also required for immunity against some bacteria, such as mycobacteria . . |
| Accessions | ENST00000371752.5 [Q9P2E3-1] ENST00000371744.5 Q5JXR6 Q2TAK0 ENST00000396105.6 [Q9P2E3-1] ENST00000371754.8 Q5JXR5 Q5JXR7 Q6P6B6 ENST00000455070.1 Q6PJM4 Q9P2E3 |