ZNFX1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051607Biological processdefense response to virus
GO_0031048Biological processregulatory ncRNA-mediated heterochromatin formation
GO_0045071Biological processnegative regulation of viral genome replication
GO_0042742Biological processdefense response to bacterium
GO_0045087Biological processinnate immune response
GO_0002218Biological processactivation of innate immune response
GO_0005741Cellular componentmitochondrial outer membrane
GO_0031380Cellular componentnuclear RNA-directed RNA polymerase complex
GO_0010494Cellular componentcytoplasmic stress granule
GO_0004386Molecular functionhelicase activity
GO_0008270Molecular functionzinc ion binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameZNFX1
Protein nameZinc finger NFX1-type containing 1
NFX1-type zinc finger-containing protein 1
ZNFX1 protein
SynonymsKIAA1404
DescriptionFUNCTION: RNA-binding protein that initiates the antiviral response and is required to restrict the replication of RNA viruses . Acts as a double-stranded RNA (dsRNA) sensor that recognizes viral RNA and then interacts with MAVS to initiate the type I interferon response (By similarity). Also required for immunity against some bacteria, such as mycobacteria . .

AccessionsENST00000371752.5 [Q9P2E3-1]
ENST00000371744.5
Q5JXR6
Q2TAK0
ENST00000396105.6 [Q9P2E3-1]
ENST00000371754.8
Q5JXR5
Q5JXR7
Q6P6B6
ENST00000455070.1
Q6PJM4
Q9P2E3