ZNF598 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ZNF598 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ZNF598 at tissue level.

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0006513Biological processprotein monoubiquitination
GO_1990116Biological processribosome-associated ubiquitin-dependent protein catabolic process
GO_0072344Biological processrescue of stalled ribosome
GO_0045947Biological processnegative regulation of translational initiation
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0022626Cellular componentcytosolic ribosome
GO_0005829Cellular componentcytosol
GO_0043022Molecular functionribosome binding
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0140517Molecular functionprotein-RNA adaptor activity
GO_0170011Molecular functionstalled ribosome sensor activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameZNF598
Protein nameE3 ubiquitin-protein ligase ZNF598 (EC 2.3.2.27) (Zinc finger protein 598)
RING-type E3 ubiquitin transferase (EC 2.3.2.27)
Alternative protein ZNF598
Zinc finger protein 598, E3 ubiquitin ligase
Synonyms
DescriptionFUNCTION: E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, leading to degradation of nascent peptide chains . ZNF598 is activated when ribosomes are stalled within an mRNA following translation of prematurely polyadenylated mRNAs . Acts as a ribosome collision sensor: specifically recognizes and binds collided di-ribosome, which arises when a trailing ribosome encounters a slower leading ribosome, leading to terminally arrest translation . Following binding to colliding ribosomes, mediates monoubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS3/uS3, and 'Lys-63'-linked polyubiquitination of RPS20/uS10 . Polyubiquitination of RPS20/uS10 promotes recruitment of the RQT (ribosome quality control trigger) complex, which drives the disassembly of stalled ribosomes, followed by degradation of nascent peptides . E3 ubiquitin-protein ligase activity is dependent on the E2 ubiquitin-conjugating enzyme UBE2D3 . Also acts as an adapter that recruits the 4EHP-GYF2 complex to mRNAs . Independently of its role in RQC, may also act as a negative regulator of interferon-stimulated gene (ISG) expression . .; FUNCTION: (Microbial infection) Required for poxvirus protein synthesis by mediating ubiquitination of RPS10/eS10 and RPS20/uS10 . Poxvirus encoding mRNAs contain unusual 5' poly(A) leaders and ZNF598 is required for their translational efficiency, possibly via its ability to suppress readthrough or sliding on shorter poly(A) tracts . .

AccessionsQ86UK7
H3BPG6
ENST00000564556.1
L8E9B0
H3BPF3
ENST00000562103.2
ENST00000567625.1
H3BR87