ZDHHC5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0062208Biological processpositive regulation of pattern recognition receptor signaling pathway
GO_0072659Biological processprotein localization to plasma membrane
GO_1905171Biological processpositive regulation of protein localization to phagocytic vesicle
GO_0045087Biological processinnate immune response
GO_0099072Biological processregulation of postsynaptic membrane neurotransmitter receptor levels
GO_1900227Biological processpositive regulation of NLRP3 inflammasome complex assembly
GO_1903078Biological processpositive regulation of protein localization to plasma membrane
GO_0018345Biological processprotein palmitoylation
GO_0006869Biological processlipid transport
GO_0098978Cellular componentglutamatergic synapse
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0030425Cellular componentdendrite
GO_0098982Cellular componentGABA-ergic synapse
GO_0000139Cellular componentGolgi membrane
GO_0045335Cellular componentphagocytic vesicle
GO_0099091Cellular componentpostsynaptic specialization, intracellular component
GO_0016409Molecular functionpalmitoyltransferase activity
GO_0019706Molecular functionprotein-cysteine S-palmitoyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameZDHHC5
Protein nameprotein S-acyltransferase (EC 2.3.1.225)
Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375)
Palmitoyltransferase (EC 2.3.1.225)
SynonymsKIAA1748
ZNF375
DescriptionFUNCTION: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, fatty acid uptake, bacterial sensing or cardiac functions . Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins . Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 . Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 . Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes . Participates also in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane. Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis . Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). .

AccessionsQ9C0B5
ENST00000529447.1
ENST00000527985.5 [Q9C0B5-2]
ENST00000528177.5
ENST00000287169.8 [Q9C0B5-1]
H0YEF4
ENST00000532842.1
E9PMA5
E9PJ97