Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 8 studies | 24% ± 8% | |
epithelial cell | 8 studies | 33% ± 12% | |
type II pneumocyte | 8 studies | 28% ± 18% | |
basal cell | 6 studies | 33% ± 13% | |
ionocyte | 4 studies | 20% ± 4% | |
classical monocyte | 4 studies | 26% ± 7% | |
macrophage | 4 studies | 21% ± 4% | |
glutamatergic neuron | 4 studies | 34% ± 13% | |
goblet cell | 4 studies | 24% ± 4% | |
hematopoietic precursor cell | 3 studies | 23% ± 4% | |
non-classical monocyte | 3 studies | 26% ± 9% | |
natural killer cell | 3 studies | 19% ± 2% | |
fibroblast | 3 studies | 20% ± 5% | |
ciliated cell | 3 studies | 28% ± 5% | |
GABAergic neuron | 3 studies | 31% ± 10% | |
transit amplifying cell | 3 studies | 32% ± 20% | |
brush cell | 3 studies | 28% ± 11% | |
astrocyte | 3 studies | 23% ± 5% | |
renal alpha-intercalated cell | 3 studies | 28% ± 7% | |
oligodendrocyte precursor cell | 3 studies | 29% ± 15% | |
secretory cell | 3 studies | 26% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
bladder | 100% | 4458.19 | 21 / 21 | 100% | 28.56 | 504 / 504 |
esophagus | 100% | 4695.85 | 1445 / 1445 | 100% | 23.96 | 183 / 183 |
intestine | 100% | 4970.80 | 966 / 966 | 100% | 33.55 | 527 / 527 |
lung | 100% | 5268.41 | 578 / 578 | 100% | 24.32 | 1155 / 1155 |
ovary | 100% | 3587.27 | 180 / 180 | 100% | 16.46 | 430 / 430 |
stomach | 100% | 3705.53 | 359 / 359 | 100% | 27.98 | 286 / 286 |
uterus | 100% | 4275.39 | 170 / 170 | 100% | 20.00 | 459 / 459 |
breast | 100% | 4710.78 | 459 / 459 | 100% | 19.29 | 1114 / 1118 |
prostate | 100% | 4366.47 | 245 / 245 | 100% | 17.80 | 500 / 502 |
thymus | 100% | 4132.87 | 653 / 653 | 100% | 17.81 | 602 / 605 |
skin | 100% | 7592.67 | 1809 / 1809 | 99% | 13.97 | 469 / 472 |
brain | 99% | 2334.21 | 2608 / 2642 | 100% | 17.67 | 705 / 705 |
kidney | 100% | 4677.12 | 89 / 89 | 99% | 16.38 | 888 / 901 |
liver | 100% | 1809.96 | 225 / 226 | 97% | 9.18 | 395 / 406 |
adrenal gland | 100% | 5660.14 | 258 / 258 | 94% | 11.00 | 217 / 230 |
pancreas | 95% | 1579.97 | 313 / 328 | 99% | 25.12 | 176 / 178 |
adipose | 100% | 5029.97 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 12.46 | 29 / 29 |
spleen | 100% | 3958.47 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 22.74 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 26.05 | 1 / 1 |
blood vessel | 100% | 3636.74 | 1334 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 100% | 5042.02 | 928 / 929 | 0% | 0 | 0 / 0 |
muscle | 100% | 3145.84 | 802 / 803 | 0% | 0 | 0 / 0 |
heart | 98% | 2696.24 | 845 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 88% | 6.93 | 70 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0072659 | Biological process | protein localization to plasma membrane |
GO_1903546 | Biological process | protein localization to photoreceptor outer segment |
GO_0036462 | Biological process | TRAIL-activated apoptotic signaling pathway |
GO_0018230 | Biological process | peptidyl-L-cysteine S-palmitoylation |
GO_0006612 | Biological process | protein targeting to membrane |
GO_1902685 | Biological process | positive regulation of receptor localization to synapse |
GO_0008277 | Biological process | regulation of G protein-coupled receptor signaling pathway |
GO_0034165 | Biological process | positive regulation of toll-like receptor 9 signaling pathway |
GO_0044873 | Biological process | lipoprotein localization to membrane |
GO_0018345 | Biological process | protein palmitoylation |
GO_0032230 | Biological process | positive regulation of synaptic transmission, GABAergic |
GO_0072657 | Biological process | protein localization to membrane |
GO_0016020 | Cellular component | membrane |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0000139 | Cellular component | Golgi membrane |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0019705 | Molecular function | protein-cysteine S-myristoyltransferase activity |
GO_0016409 | Molecular function | palmitoyltransferase activity |
GO_0019706 | Molecular function | protein-cysteine S-palmitoyltransferase activity |
GO_0140439 | Molecular function | protein-cysteine S-stearoyltransferase activity |
Gene name | ZDHHC3 |
Protein name | Palmitoyltransferase ZDHHC3 (EC 2.3.1.225) (Acyltransferase ZDHHC3) (EC 2.3.1.-) (Protein DHHC1) (Zinc finger DHHC domain-containing protein 3) (DHHC-3) Palmitoyltransferase (EC 2.3.1.225) Zinc finger DHHC-type palmitoyltransferase 3 |
Synonyms | HSD49 |
Description | FUNCTION: Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates . Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Plays an important role in G protein-coupled receptor signaling pathways involving GNAQ and potentially other heterotrimeric G proteins by regulating their dynamic association with the plasma membrane . Palmitoylates ITGA6 and ITGB4, thereby regulating the alpha-6/beta-4 integrin localization, expression and function in cell adhesion to laminin . Plays a role in the TRAIL-activated apoptotic signaling pathway most probably through the palmitoylation and localization to the plasma membrane of TNFRSF10A . In the brain, by palmitoylating the gamma subunit GABRG2 of GABA(A) receptors and regulating their postsynaptic accumulation, plays a role in synaptic GABAergic inhibitory function and GABAergic innervation (By similarity). Palmitoylates the neuronal protein GAP43 which is also involved in the formation of GABAergic synapses (By similarity). Palmitoylates NCDN thereby regulating its association with endosome membranes (By similarity). Probably palmitoylates PRCD and is involved in its proper localization within the photoreceptor (By similarity). Could mediate the palmitoylation of NCAM1 and regulate neurite outgrowth (By similarity). Could palmitoylate DNAJC5 and regulate its localization to Golgi membranes (By similarity). Also constitutively palmitoylates DLG4 (By similarity). May also palmitoylate SNAP25 (By similarity). Could palmitoylate the glutamate receptors GRIA1 and GRIA2 but this has not been confirmed in vivo (By similarity). Could also palmitoylate the D(2) dopamine receptor DRD2 . May also palmitoylate LAMTOR1, promoting its localization to lysosomal membranes . .; FUNCTION: May also function as a calcium transporter. . |
Accessions | ENST00000296127.7 [Q9NYG2-2] ENST00000342790.8 A0A994J7J2 ENST00000705994.1 H0Y6A5 H7C365 C9JNU5 ENST00000455235.5 ENST00000419642.1 F8W6M3 ENST00000443879.2 ENST00000424952.7 [Q9NYG2-1] H7C1U6 Q9NYG2 ENST00000339420.7 |