ZDHHC3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0072659Biological processprotein localization to plasma membrane
GO_1903546Biological processprotein localization to photoreceptor outer segment
GO_0036462Biological processTRAIL-activated apoptotic signaling pathway
GO_0018230Biological processpeptidyl-L-cysteine S-palmitoylation
GO_0006612Biological processprotein targeting to membrane
GO_1902685Biological processpositive regulation of receptor localization to synapse
GO_0008277Biological processregulation of G protein-coupled receptor signaling pathway
GO_0034165Biological processpositive regulation of toll-like receptor 9 signaling pathway
GO_0044873Biological processlipoprotein localization to membrane
GO_0018345Biological processprotein palmitoylation
GO_0032230Biological processpositive regulation of synaptic transmission, GABAergic
GO_0072657Biological processprotein localization to membrane
GO_0016020Cellular componentmembrane
GO_0005794Cellular componentGolgi apparatus
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0042803Molecular functionprotein homodimerization activity
GO_0019705Molecular functionprotein-cysteine S-myristoyltransferase activity
GO_0016409Molecular functionpalmitoyltransferase activity
GO_0019706Molecular functionprotein-cysteine S-palmitoyltransferase activity
GO_0140439Molecular functionprotein-cysteine S-stearoyltransferase activity

IV. Literature review

[source]
Gene nameZDHHC3
Protein namePalmitoyltransferase ZDHHC3 (EC 2.3.1.225) (Acyltransferase ZDHHC3) (EC 2.3.1.-) (Protein DHHC1) (Zinc finger DHHC domain-containing protein 3) (DHHC-3)
Palmitoyltransferase (EC 2.3.1.225)
Zinc finger DHHC-type palmitoyltransferase 3
SynonymsHSD49
DescriptionFUNCTION: Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates . Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Plays an important role in G protein-coupled receptor signaling pathways involving GNAQ and potentially other heterotrimeric G proteins by regulating their dynamic association with the plasma membrane . Palmitoylates ITGA6 and ITGB4, thereby regulating the alpha-6/beta-4 integrin localization, expression and function in cell adhesion to laminin . Plays a role in the TRAIL-activated apoptotic signaling pathway most probably through the palmitoylation and localization to the plasma membrane of TNFRSF10A . In the brain, by palmitoylating the gamma subunit GABRG2 of GABA(A) receptors and regulating their postsynaptic accumulation, plays a role in synaptic GABAergic inhibitory function and GABAergic innervation (By similarity). Palmitoylates the neuronal protein GAP43 which is also involved in the formation of GABAergic synapses (By similarity). Palmitoylates NCDN thereby regulating its association with endosome membranes (By similarity). Probably palmitoylates PRCD and is involved in its proper localization within the photoreceptor (By similarity). Could mediate the palmitoylation of NCAM1 and regulate neurite outgrowth (By similarity). Could palmitoylate DNAJC5 and regulate its localization to Golgi membranes (By similarity). Also constitutively palmitoylates DLG4 (By similarity). May also palmitoylate SNAP25 (By similarity). Could palmitoylate the glutamate receptors GRIA1 and GRIA2 but this has not been confirmed in vivo (By similarity). Could also palmitoylate the D(2) dopamine receptor DRD2 . May also palmitoylate LAMTOR1, promoting its localization to lysosomal membranes . .; FUNCTION: May also function as a calcium transporter. .

AccessionsENST00000296127.7 [Q9NYG2-2]
ENST00000342790.8
A0A994J7J2
ENST00000705994.1
H0Y6A5
H7C365
C9JNU5
ENST00000455235.5
ENST00000419642.1
F8W6M3
ENST00000443879.2
ENST00000424952.7 [Q9NYG2-1]
H7C1U6
Q9NYG2
ENST00000339420.7