ZCCHC8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000398Biological processmRNA splicing, via spliceosome
GO_0031124Biological processmRNA 3'-end processing
GO_0016076Biological processsnRNA catabolic process
GO_0006396Biological processRNA processing
GO_0031499Cellular componentTRAMP complex
GO_0005730Cellular componentnucleolus
GO_0071013Cellular componentcatalytic step 2 spliceosome
GO_0016604Cellular componentnuclear body
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameZCCHC8
Protein nameZinc finger CCHC domain-containing protein 8 (TRAMP-like complex RNA-binding factor ZCCHC8)
Zinc finger CCHC-type containing 8
Synonyms
DescriptionFUNCTION: Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs . NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing (Probable). It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function . .

AccessionsF5H6J5
ENST00000536306.5 [Q6NZY4-2]
ENST00000633063.3 [Q6NZY4-1]
F5GYI9
ENST00000540586.1
F5GX80
ENST00000544054.5
ENST00000536663.5
ENST00000543897.5 [Q6NZY4-2]
Q6NZY4