Insufficient scRNA-seq data for expression of ZCCHC3 at single-cell level.
Insufficient scRNA-seq data for expression of ZCCHC3 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
adrenal gland | 100% | 1330.61 | 258 / 258 | 100% | 55.60 | 230 / 230 |
esophagus | 100% | 1166.69 | 1445 / 1445 | 100% | 32.80 | 183 / 183 |
ovary | 100% | 1721.26 | 180 / 180 | 100% | 52.39 | 430 / 430 |
stomach | 100% | 1164.37 | 359 / 359 | 100% | 35.73 | 286 / 286 |
brain | 100% | 1280.89 | 2640 / 2642 | 100% | 37.31 | 705 / 705 |
thymus | 100% | 1377.42 | 653 / 653 | 100% | 47.00 | 604 / 605 |
lung | 100% | 1069.65 | 577 / 578 | 100% | 33.92 | 1155 / 1155 |
kidney | 100% | 1161.57 | 89 / 89 | 100% | 31.02 | 899 / 901 |
pancreas | 100% | 701.55 | 327 / 328 | 100% | 32.10 | 178 / 178 |
skin | 100% | 900.16 | 1806 / 1809 | 100% | 58.96 | 471 / 472 |
intestine | 100% | 1469.39 | 966 / 966 | 100% | 35.89 | 525 / 527 |
bladder | 100% | 1199.29 | 21 / 21 | 100% | 36.81 | 502 / 504 |
prostate | 100% | 1208.32 | 245 / 245 | 100% | 29.70 | 500 / 502 |
breast | 100% | 1059.53 | 459 / 459 | 100% | 34.96 | 1113 / 1118 |
uterus | 100% | 1584.65 | 170 / 170 | 99% | 48.95 | 456 / 459 |
liver | 100% | 832.00 | 226 / 226 | 98% | 24.90 | 398 / 406 |
adipose | 100% | 1110.35 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 39.76 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 56.63 | 29 / 29 |
spleen | 100% | 2448.09 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 33.36 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 22.27 | 1 / 1 |
blood vessel | 100% | 1030.84 | 1334 / 1335 | 0% | 0 | 0 / 0 |
heart | 100% | 754.74 | 858 / 861 | 0% | 0 | 0 / 0 |
muscle | 99% | 548.02 | 791 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 89% | 1086.74 | 827 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0009597 | Biological process | detection of virus |
GO_0051607 | Biological process | defense response to virus |
GO_1900246 | Biological process | positive regulation of RIG-I signaling pathway |
GO_0071360 | Biological process | cellular response to exogenous dsRNA |
GO_0032481 | Biological process | positive regulation of type I interferon production |
GO_0045087 | Biological process | innate immune response |
GO_0002218 | Biological process | activation of innate immune response |
GO_0005737 | Cellular component | cytoplasm |
GO_0003690 | Molecular function | double-stranded DNA binding |
GO_0005515 | Molecular function | protein binding |
GO_0008270 | Molecular function | zinc ion binding |
GO_0003723 | Molecular function | RNA binding |
Gene name | ZCCHC3 |
Protein name | Zinc finger CCHC domain-containing protein 3 |
Synonyms | C20orf99 |
Description | FUNCTION: Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses . Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as RIGI, IFIH1/MDA5 and CGAS . Acts as a co-sensor for recognition of double-stranded DNA (dsDNA) by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus . Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation . Promotes sensing of viral RNA by RIGI-like receptors proteins RIGI and IFIH1/MDA5 via two mechanisms: binds double-stranded RNA (dsRNA), enhancing the binding of RIGI and IFIH1/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of RIGI and IFIH1/MDA5 . . |
Accessions | Q9NUD5 ENST00000500893.4 [Q9NUD5-1] |