ZCCHC3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ZCCHC3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ZCCHC3 at tissue level.

III. Associated gene sets

GO_0009597Biological processdetection of virus
GO_0051607Biological processdefense response to virus
GO_1900246Biological processpositive regulation of RIG-I signaling pathway
GO_0071360Biological processcellular response to exogenous dsRNA
GO_0032481Biological processpositive regulation of type I interferon production
GO_0045087Biological processinnate immune response
GO_0002218Biological processactivation of innate immune response
GO_0005737Cellular componentcytoplasm
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameZCCHC3
Protein nameZinc finger CCHC domain-containing protein 3
SynonymsC20orf99
DescriptionFUNCTION: Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses . Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as RIGI, IFIH1/MDA5 and CGAS . Acts as a co-sensor for recognition of double-stranded DNA (dsDNA) by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus . Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation . Promotes sensing of viral RNA by RIGI-like receptors proteins RIGI and IFIH1/MDA5 via two mechanisms: binds double-stranded RNA (dsRNA), enhancing the binding of RIGI and IFIH1/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of RIGI and IFIH1/MDA5 . .

AccessionsQ9NUD5
ENST00000500893.4 [Q9NUD5-1]