ZBTB48 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ZBTB48 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ZBTB48 at tissue level.

III. Associated gene sets

GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0010833Biological processtelomere maintenance via telomere lengthening
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000781Cellular componentchromosome, telomeric region
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0003691Molecular functiondouble-stranded telomeric DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0000976Molecular functiontranscription cis-regulatory region binding

IV. Literature review

[source]
Gene nameZBTB48
Protein nameTelomere zinc finger-associated protein (TZAP) (Krueppel-related zinc finger protein 3) (hKR3) (Zinc finger and BTB domain-containing protein 48) (Zinc finger protein 855)
Zinc finger and BTB domain containing 48
SynonymsTZAP
HKR3
ZNF855
DescriptionFUNCTION: Telomere-binding protein that acts as a regulator of telomere length . Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat . Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres . Also acts as a transcription regulator that binds to promoter regions . Regulates expression of a small subset of genes, including MTFP1 . Regulates expression the J and/or S elements in MHC II promoter . Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A . .

AccessionsQ5SY21
ENST00000466813.1
ENST00000435905.5
K7ENV2
Q5SY20
ENST00000488936.1
ENST00000377674.9
ENST00000319084.9
P10074
K7EM76