YTHDF3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070925Biological processorganelle assembly
GO_0060339Biological processnegative regulation of type I interferon-mediated signaling pathway
GO_0061157Biological processmRNA destabilization
GO_0045727Biological processpositive regulation of translation
GO_0045948Biological processpositive regulation of translational initiation
GO_0034063Biological processstress granule assembly
GO_0043488Biological processregulation of mRNA stability
GO_1901163Biological processregulation of trophoblast cell migration
GO_0000932Cellular componentP-body
GO_0005829Cellular componentcytosol
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005737Cellular componentcytoplasm
GO_0043022Molecular functionribosome binding
GO_0005515Molecular functionprotein binding
GO_0003729Molecular functionmRNA binding
GO_1990247Molecular functionN6-methyladenosine-containing RNA reader activity
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameYTHDF3
Protein nameYTH domain-containing family protein 3 (DF3)
YTH N6-methyladenosine RNA binding protein 3
YTH domain-containing family protein
SynonymshCG_41077
DescriptionFUNCTION: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability . M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing . Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex or PAN3 . The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation . Acts as a negative regulator of type I interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs (By similarity). Binds to FOXO3 mRNAs independently of METTL3-mediated m6A modification (By similarity). Can also act as a regulator of mRNA stability in cooperation with YTHDF2 by binding to m6A-containing mRNA and promoting their degradation . Recognizes and binds m6A-containing circular RNAs (circRNAs); circRNAs are generated through back-splicing of pre-mRNAs, a non-canonical splicing process promoted by dsRNA structures across circularizing exons . Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation . The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules . May also recognize and bind N1-methyladenosine (m1A)-containing mRNAs: inhibits trophoblast invasion by binding to m1A-methylated transcripts of IGF1R, promoting their degradation . .; FUNCTION: Has some antiviral activity against HIV-1 virus: incorporated into HIV-1 particles in a nucleocapsid-dependent manner and reduces viral infectivity in the next cycle of infection . May interfere with this early step of the viral life cycle by binding to N6-methyladenosine (m6A) modified sites on the HIV-1 RNA genome . .

FUNCTION: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. .

FUNCTION: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. .

FUNCTION: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. .

AccessionsENST00000612880.4
ENST00000517371.5
A0A087X0C3
A0A087WY31
A0A087WU40
A0A087X0U5
ENST00000539294.6
ENST00000623280.3
A0A087WU63
ENST00000621413.4
ENST00000617952.4
A0A087X0Q1
ENST00000613853.4
Q7Z739
ENST00000617200.1
A0A087WWB0
ENST00000619337.4
ENST00000621957.4
A0A024R7W5
ENST00000615676.1
ENST00000621820.4
ENST00000621890.4
S4R373