XRCC3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of XRCC3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of XRCC3 at tissue level.

III. Associated gene sets

GO_0090656Biological processt-circle formation
GO_0006281Biological processDNA repair
GO_0036297Biological processinterstrand cross-link repair
GO_0045003Biological processdouble-strand break repair via synthesis-dependent strand annealing
GO_0090737Biological processtelomere maintenance via telomere trimming
GO_0071140Biological processresolution of mitotic recombination intermediates
GO_0006974Biological processDNA damage response
GO_0000722Biological processtelomere maintenance via recombination
GO_0090657Biological processtelomeric loop disassembly
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0010824Biological processregulation of centrosome duplication
GO_0090267Biological processpositive regulation of mitotic cell cycle spindle assembly checkpoint
GO_0006310Biological processDNA recombination
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005739Cellular componentmitochondrion
GO_0005657Cellular componentreplication fork
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000781Cellular componentchromosome, telomeric region
GO_0033065Cellular componentRad51C-XRCC3 complex
GO_0005634Cellular componentnucleus
GO_0008821Molecular functioncrossover junction DNA endonuclease activity
GO_0140664Molecular functionATP-dependent DNA damage sensor activity
GO_0000400Molecular functionfour-way junction DNA binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameXRCC3
Protein nameX-ray repair cross complementing 3
DNA repair protein XRCC3 (X-ray repair cross-complementing protein 3)
Full-length cDNA clone CS0DC014YE11 of Neuroblastoma of Homo sapiens (human) (X-ray repair complementing defective repair in Chinese hamster cells 3) (cDNA FLJ12767 fis, clone NT2RP2001536, highly similar to DNA-repair protein XRCC3) (cDNA FLJ13584 fis, clone PLACE1009113, highly similar to DNA-repair protein XRCC3) (cDNA FLJ42507 fis, clone BRACE2040514, highly similar to DNA-repair protein XRCC3)
SynonymshCG_25500
DescriptionFUNCTION: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C. .

AccessionsO43542
ENST00000554170.1
ENST00000554913.5
ENST00000553361.5
ENST00000554974.5
ENST00000557439.5
G3V2L7
G3V3Q2
ENST00000553264.5
ENST00000553332.5
G3V5K0
ENST00000556980.5
G3V2P3
ENST00000555055.6
G3V3H9
G3V3C8
G3V399
ENST00000556682.5
Q53XC8
ENST00000352127.11
ENST00000555964.5