XPR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030643Biological processintracellular phosphate ion homeostasis
GO_0009615Biological processresponse to virus
GO_0016036Biological processcellular response to phosphate starvation
GO_0046718Biological processsymbiont entry into host cell
GO_0035435Biological processphosphate ion transmembrane transport
GO_0006817Biological processphosphate ion transport
GO_0005794Cellular componentGolgi apparatus
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005315Molecular functionphosphate transmembrane transporter activity
GO_0015562Molecular functionefflux transmembrane transporter activity
GO_0000822Molecular functioninositol hexakisphosphate binding
GO_0001618Molecular functionvirus receptor activity

IV. Literature review

[source]
Gene nameXPR1
Protein nameSolute carrier family 53 member 1 (Phosphate exporter SLC53A1) (Protein SYG1 homolog) (Xenotropic and polytropic murine leukemia virus receptor X3) (X-receptor) (Xenotropic and polytropic retrovirus receptor 1)
SynonymsSYG1
X3
SLC53A1
DescriptionFUNCTION: Inorganic ion transporter that mediates phosphate ion export across plasma membrane. Plays a major role in phosphate homeostasis, preventing intracellular phosphate accumulation and possible calcium phosphate precipitation, ultimately preserving calcium signaling. The molecular mechanism of phosphate transport, whether electrogenic, electroneutral or coupled to other ions, remains to be elucidated (By similarity). Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7), important intracellular signaling molecules involved in regulation of phosphate flux . .

AccessionsQ9UBH6
ENST00000367590.9 [Q9UBH6-1]
ENST00000367589.3 [Q9UBH6-2]