XPA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010996Biological processresponse to auditory stimulus
GO_0006281Biological processDNA repair
GO_0000715Biological processnucleotide-excision repair, DNA damage recognition
GO_0009650Biological processUV protection
GO_0006289Biological processnucleotide-excision repair
GO_0070914Biological processUV-damage excision repair
GO_0034504Biological processprotein localization to nucleus
GO_0006284Biological processbase-excision repair
GO_1901255Biological processnucleotide-excision repair involved in interstrand cross-link repair
GO_0000110Cellular componentnucleotide-excision repair factor 1 complex
GO_0005654Cellular componentnucleoplasm
GO_0045171Cellular componentintercellular bridge
GO_0005662Cellular componentDNA replication factor A complex
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0019904Molecular functionprotein domain specific binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding
GO_0003684Molecular functiondamaged DNA binding

IV. Literature review

[source]
Gene nameXPA
Protein nameXPA, DNA damage recognition and repair factor
Mutant xeroderma pigmentosum complementation group A
DNA repair protein complementing XP-A cells (Xeroderma pigmentosum group A-complementing protein)
SynonymsXPAC
DescriptionFUNCTION: Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. .

AccessionsW0FSR8
ENST00000375128.5
ENST00000462523.5
P23025
F2Z2T2