WIPI1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000786Biological processpositive regulation of autophagosome assembly
GO_0030242Biological processautophagy of peroxisome
GO_0048203Biological processvesicle targeting, trans-Golgi to endosome
GO_0000045Biological processautophagosome assembly
GO_0006497Biological processprotein lipidation
GO_0034497Biological processprotein localization to phagophore assembly site
GO_0009267Biological processcellular response to starvation
GO_0000422Biological processautophagy of mitochondrion
GO_0006914Biological processautophagy
GO_0061723Biological processglycophagy
GO_0044804Biological processnucleophagy
GO_0005856Cellular componentcytoskeleton
GO_0034045Cellular componentphagophore assembly site membrane
GO_0000421Cellular componentautophagosome membrane
GO_0030136Cellular componentclathrin-coated vesicle
GO_0019898Cellular componentextrinsic component of membrane
GO_0005802Cellular componenttrans-Golgi network
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0000407Cellular componentphagophore assembly site
GO_0005737Cellular componentcytoplasm
GO_0010008Cellular componentendosome membrane
GO_0005102Molecular functionsignaling receptor binding
GO_0032266Molecular functionphosphatidylinositol-3-phosphate binding
GO_0030331Molecular functionnuclear estrogen receptor binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0050681Molecular functionnuclear androgen receptor binding
GO_0080025Molecular functionphosphatidylinositol-3,5-bisphosphate binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameWIPI1
Protein nameWD repeat domain phosphoinositide-interacting protein 1 (WIPI-1) (Atg18 protein homolog) (WD40 repeat protein interacting with phosphoinositides of 49 kDa) (WIPI 49 kDa)
WD repeat domain, phosphoinositide interacting 1
SynonymshCG_28468
WIPI49
DescriptionFUNCTION: Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation . Plays an important role in starvation- and calcium-mediated autophagy, as well as in mitophagy . Functions downstream of the ULK1 and PI3-kinases that produce phosphatidylinositol 3-phosphate (PtdIns3P) on membranes of the endoplasmic reticulum once activated . Binds phosphatidylinositol 3-phosphate (PtdIns3P), and maybe other phosphoinositides including PtdIns3,5P2 and PtdIns5P, and is recruited to phagophore assembly sites at the endoplasmic reticulum membranes . There, it assists WIPI2 in the recruitment of ATG12-ATG5-ATG16L1, a complex that directly controls the elongation of the nascent autophagosomal membrane . Together with WDR45/WIPI4, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes . Involved in xenophagy of Staphylococcus aureus . Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation . Also plays a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy . May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway . .

AccessionsK7EKC5
K7ELY0
ENST00000262139.10 [Q5MNZ9-1]
ENST00000585393.1
ENST00000589316.5
Q5MNZ9
K7EK57
ENST00000592645.5
ENST00000546360.5
ENST00000591744.1
K7EKN0
G5EA37