WEE1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048812Biological processneuron projection morphogenesis
GO_2000134Biological processnegative regulation of G1/S transition of mitotic cell cycle
GO_0030010Biological processestablishment of cell polarity
GO_0000086Biological processG2/M transition of mitotic cell cycle
GO_0006468Biological processprotein phosphorylation
GO_0051301Biological processcell division
GO_0010972Biological processnegative regulation of G2/M transition of mitotic cell cycle
GO_0045740Biological processpositive regulation of DNA replication
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0004715Molecular functionnon-membrane spanning protein tyrosine kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0000287Molecular functionmagnesium ion binding

IV. Literature review

[source]
Gene nameWEE1
Protein nameWee1-like protein kinase (EC 2.7.10.2)
WEE1 G2 checkpoint kinase
non-specific protein-tyrosine kinase (EC 2.7.10.2)
Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase)
Synonyms
DescriptionFUNCTION: Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15' . Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase . Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur . Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated . A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation . .

AccessionsENST00000450114.7 [P30291-1]
H0YEJ2
Q86V29
ENST00000681684.1 [P30291-2]
ENST00000299613.10 [P30291-2]
E9PQ51
A0A7P0TBN9
E9PRU3
ENST00000527848.1
P30291
ENST00000530175.5
E9PRI3
ENST00000530712.6
ENST00000524612.5
ENST00000680141.1
Q6NSL2