Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| basal cell | 9 studies | 26% ± 12% | |
| ciliated cell | 9 studies | 29% ± 17% | |
| epithelial cell | 7 studies | 38% ± 19% | |
| B cell | 5 studies | 20% ± 4% | |
| secretory cell | 4 studies | 20% ± 5% | |
| luminal hormone-sensing cell of mammary gland | 4 studies | 38% ± 8% | |
| abnormal cell | 3 studies | 21% ± 4% | |
| kidney loop of Henle epithelial cell | 3 studies | 20% ± 6% | |
| extravillous trophoblast | 3 studies | 32% ± 1% | |
| smooth muscle cell | 3 studies | 25% ± 6% | |
| goblet cell | 3 studies | 28% ± 18% | |
| transit amplifying cell | 3 studies | 38% ± 20% | |
| erythroblast | 3 studies | 24% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 2531.52 | 1444 / 1445 | 100% | 28.77 | 183 / 183 |
| uterus | 100% | 3496.15 | 170 / 170 | 99% | 25.44 | 455 / 459 |
| bladder | 100% | 3143.24 | 21 / 21 | 99% | 20.16 | 498 / 504 |
| ovary | 100% | 1562.07 | 180 / 180 | 99% | 17.33 | 424 / 430 |
| intestine | 100% | 2392.81 | 966 / 966 | 98% | 17.37 | 516 / 527 |
| thymus | 100% | 1840.08 | 652 / 653 | 98% | 23.16 | 591 / 605 |
| lung | 98% | 1386.48 | 566 / 578 | 99% | 18.64 | 1145 / 1155 |
| stomach | 96% | 2088.19 | 345 / 359 | 98% | 17.57 | 279 / 286 |
| prostate | 99% | 1759.42 | 242 / 245 | 94% | 13.79 | 473 / 502 |
| skin | 100% | 5453.50 | 1809 / 1809 | 93% | 12.89 | 437 / 472 |
| breast | 93% | 2839.47 | 426 / 459 | 99% | 25.68 | 1111 / 1118 |
| liver | 94% | 1366.59 | 213 / 226 | 83% | 10.13 | 336 / 406 |
| kidney | 92% | 1097.18 | 82 / 89 | 72% | 8.42 | 646 / 901 |
| pancreas | 52% | 349.57 | 170 / 328 | 94% | 12.53 | 168 / 178 |
| adrenal gland | 80% | 610.04 | 207 / 258 | 44% | 4.00 | 102 / 230 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 22.78 | 29 / 29 |
| spleen | 100% | 1182.70 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 30.40 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 14.29 | 1 / 1 |
| blood vessel | 100% | 2443.90 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 95% | 1395.92 | 1144 / 1204 | 0% | 0 | 0 / 0 |
| heart | 95% | 2771.09 | 816 / 861 | 0% | 0 | 0 / 0 |
| muscle | 77% | 665.28 | 622 / 803 | 0% | 0 | 0 / 0 |
| brain | 10% | 68.87 | 276 / 2642 | 64% | 10.64 | 450 / 705 |
| eye | 0% | 0 | 0 / 0 | 51% | 4.02 | 41 / 80 |
| peripheral blood | 26% | 821.77 | 241 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0048812 | Biological process | neuron projection morphogenesis |
| GO_2000134 | Biological process | negative regulation of G1/S transition of mitotic cell cycle |
| GO_0030010 | Biological process | establishment of cell polarity |
| GO_0000086 | Biological process | G2/M transition of mitotic cell cycle |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0051301 | Biological process | cell division |
| GO_0010972 | Biological process | negative regulation of G2/M transition of mitotic cell cycle |
| GO_0045740 | Biological process | positive regulation of DNA replication |
| GO_0000226 | Biological process | microtubule cytoskeleton organization |
| GO_0005730 | Cellular component | nucleolus |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0004713 | Molecular function | protein tyrosine kinase activity |
| GO_0004715 | Molecular function | non-membrane spanning protein tyrosine kinase activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0000287 | Molecular function | magnesium ion binding |
| Gene name | WEE1 |
| Protein name | Wee1-like protein kinase (EC 2.7.10.2) WEE1 G2 checkpoint kinase non-specific protein-tyrosine kinase (EC 2.7.10.2) Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase) |
| Synonyms | |
| Description | FUNCTION: Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15' . Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase . Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur . Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated . A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation . . |
| Accessions | ENST00000450114.7 [P30291-1] H0YEJ2 Q86V29 ENST00000681684.1 [P30291-2] ENST00000299613.10 [P30291-2] E9PQ51 A0A7P0TBN9 E9PRU3 ENST00000527848.1 P30291 ENST00000530175.5 E9PRI3 ENST00000530712.6 ENST00000524612.5 ENST00000680141.1 Q6NSL2 |