WDR6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010507Biological processnegative regulation of autophagy
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0070314Biological processG1 to G0 transition
GO_0002130Biological processwobble position ribose methylation
GO_0030488Biological processtRNA methylation
GO_0008180Cellular componentCOP9 signalosome
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0000049Molecular functiontRNA binding
GO_0030234Molecular functionenzyme regulator activity
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameWDR6
Protein nametRNA (34-2'-O)-methyltransferase regulator WDR6 (WD repeat-containing protein 6)
WD repeat domain 6
Synonyms
DescriptionFUNCTION: Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 34 of the tRNA anticodon loop of substrate tRNAs . Required for the correct positioning of the substrate tRNA for methylation . Required to suppress amino acid starvation-induced autophagy . Enhances the STK11/LKB1-induced cell growth suppression activity . .

AccessionsE9PDU5
C9K020
ENST00000395474.7
ENST00000419837.1
ENST00000415265.6
V9GZ65
Q9NNW5
A0A087X295
ENST00000448293.5
ENST00000438660.5
E5RFX3
V9GYU1
ENST00000452875.5
F8WE36
ENST00000491365.1
ENST00000610967.4
Q6PKC6
ENST00000420783.7
ENST00000627177.1
ENST00000608424.6
Q6AZD6
ENST00000429900.6
ENST00000489427.1
C9JFP6
E9PBK6
V9GZ48