Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 12 studies | 34% ± 15% | |
oligodendrocyte | 11 studies | 32% ± 12% | |
endothelial cell | 9 studies | 31% ± 17% | |
oligodendrocyte precursor cell | 9 studies | 30% ± 14% | |
GABAergic neuron | 7 studies | 41% ± 21% | |
glutamatergic neuron | 6 studies | 44% ± 25% | |
interneuron | 6 studies | 37% ± 23% | |
epithelial cell | 6 studies | 32% ± 16% | |
macrophage | 5 studies | 23% ± 5% | |
microglial cell | 5 studies | 22% ± 5% | |
neuron | 5 studies | 34% ± 17% | |
fibroblast | 5 studies | 23% ± 7% | |
cardiac muscle cell | 4 studies | 19% ± 1% | |
endothelial cell of lymphatic vessel | 4 studies | 23% ± 5% | |
GABAergic interneuron | 3 studies | 22% ± 3% | |
granule cell | 3 studies | 17% ± 1% | |
retinal ganglion cell | 3 studies | 18% ± 2% | |
retinal rod cell | 3 studies | 28% ± 7% | |
hepatocyte | 3 studies | 40% ± 12% | |
basal cell | 3 studies | 37% ± 25% | |
goblet cell | 3 studies | 29% ± 14% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 3290.58 | 1445 / 1445 | 100% | 14.05 | 183 / 183 |
liver | 100% | 4046.96 | 226 / 226 | 100% | 13.17 | 406 / 406 |
pancreas | 100% | 2337.26 | 328 / 328 | 100% | 14.96 | 178 / 178 |
brain | 100% | 3145.99 | 2641 / 2642 | 100% | 20.09 | 705 / 705 |
bladder | 100% | 3592.19 | 21 / 21 | 100% | 15.13 | 503 / 504 |
prostate | 100% | 4341.65 | 245 / 245 | 100% | 12.85 | 501 / 502 |
lung | 100% | 2726.61 | 577 / 578 | 100% | 13.87 | 1154 / 1155 |
intestine | 100% | 3568.48 | 966 / 966 | 100% | 14.13 | 525 / 527 |
uterus | 100% | 4601.80 | 170 / 170 | 100% | 14.90 | 457 / 459 |
breast | 100% | 3482.91 | 459 / 459 | 99% | 11.48 | 1112 / 1118 |
skin | 100% | 3907.05 | 1809 / 1809 | 99% | 13.72 | 469 / 472 |
thymus | 100% | 6292.86 | 653 / 653 | 99% | 18.50 | 601 / 605 |
kidney | 100% | 3870.83 | 89 / 89 | 99% | 14.27 | 894 / 901 |
ovary | 100% | 5283.86 | 180 / 180 | 99% | 9.44 | 426 / 430 |
stomach | 100% | 2662.66 | 359 / 359 | 99% | 12.66 | 282 / 286 |
adrenal gland | 100% | 4316.00 | 258 / 258 | 98% | 13.83 | 226 / 230 |
adipose | 100% | 2829.44 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 14.04 | 29 / 29 |
spleen | 100% | 3919.94 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 12.29 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 6.06 | 1 / 1 |
blood vessel | 100% | 2933.92 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 2360.55 | 800 / 803 | 0% | 0 | 0 / 0 |
heart | 98% | 2344.80 | 843 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 98% | 12.63 | 78 / 80 |
peripheral blood | 87% | 1838.00 | 809 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0031669 | Biological process | cellular response to nutrient levels |
GO_1904263 | Biological process | positive regulation of TORC1 signaling |
GO_1904262 | Biological process | negative regulation of TORC1 signaling |
GO_0034198 | Biological process | cellular response to amino acid starvation |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0005774 | Cellular component | vacuolar membrane |
GO_0005829 | Cellular component | cytosol |
GO_0061700 | Cellular component | GATOR2 complex |
GO_0035859 | Cellular component | Seh1-associated complex |
GO_0005765 | Cellular component | lysosomal membrane |
GO_0035591 | Molecular function | signaling adaptor activity |
GO_0005515 | Molecular function | protein binding |
GO_0046872 | Molecular function | metal ion binding |
Gene name | WDR59 |
Protein name | WD repeat domain 59 GATOR2 complex protein WDR59 (WD repeat-containing protein 59) |
Synonyms | KIAA1923 FP977 |
Description | FUNCTION: As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway . The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex . GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 . In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation . In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex . . |
Accessions | ENST00000536050.5 H3BV71 H3BNY4 Q6PJI9 H3BUE9 ENST00000616369.4 [Q6PJI9-2] ENST00000566924.1 ENST00000563111.2 ENST00000569229.5 ENST00000262144.11 [Q6PJI9-1] H3BMH3 B7Z7V6 ENST00000563797.5 ENST00000564859.1 H3BR95 |