WDR59 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031669Biological processcellular response to nutrient levels
GO_1904263Biological processpositive regulation of TORC1 signaling
GO_1904262Biological processnegative regulation of TORC1 signaling
GO_0034198Biological processcellular response to amino acid starvation
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005774Cellular componentvacuolar membrane
GO_0005829Cellular componentcytosol
GO_0061700Cellular componentGATOR2 complex
GO_0035859Cellular componentSeh1-associated complex
GO_0005765Cellular componentlysosomal membrane
GO_0035591Molecular functionsignaling adaptor activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameWDR59
Protein nameWD repeat domain 59
GATOR2 complex protein WDR59 (WD repeat-containing protein 59)
SynonymsKIAA1923
FP977
DescriptionFUNCTION: As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway . The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex . GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 . In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation . In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex . .

AccessionsENST00000536050.5
H3BV71
H3BNY4
Q6PJI9
H3BUE9
ENST00000616369.4 [Q6PJI9-2]
ENST00000566924.1
ENST00000563111.2
ENST00000569229.5
ENST00000262144.11 [Q6PJI9-1]
H3BMH3
B7Z7V6
ENST00000563797.5
ENST00000564859.1
H3BR95