Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| natural killer cell | 10 studies | 18% ± 3% | |
| CD16-positive, CD56-dim natural killer cell, human | 9 studies | 19% ± 4% | |
| fibroblast | 9 studies | 22% ± 9% | |
| plasma cell | 7 studies | 32% ± 9% | |
| CD16-negative, CD56-bright natural killer cell, human | 5 studies | 18% ± 2% | |
| endothelial cell | 5 studies | 20% ± 5% | |
| plasmacytoid dendritic cell | 5 studies | 21% ± 4% | |
| classical monocyte | 4 studies | 25% ± 8% | |
| plasmablast | 4 studies | 32% ± 16% | |
| epithelial cell | 4 studies | 33% ± 10% | |
| CD8-positive, alpha-beta T cell | 3 studies | 20% ± 3% | |
| mature NK T cell | 3 studies | 18% ± 3% | |
| non-classical monocyte | 3 studies | 33% ± 6% | |
| smooth muscle cell | 3 studies | 21% ± 3% | |
| pericyte | 3 studies | 21% ± 1% | |
| ciliated cell | 3 studies | 24% ± 3% | |
| abnormal cell | 3 studies | 19% ± 3% | |
| connective tissue cell | 3 studies | 18% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| adrenal gland | 100% | 6275.57 | 258 / 258 | 100% | 15.86 | 230 / 230 |
| esophagus | 100% | 4265.39 | 1445 / 1445 | 100% | 11.83 | 183 / 183 |
| kidney | 100% | 4868.81 | 89 / 89 | 100% | 15.89 | 901 / 901 |
| liver | 100% | 3316.46 | 226 / 226 | 100% | 14.58 | 406 / 406 |
| ovary | 100% | 4843.91 | 180 / 180 | 100% | 23.60 | 430 / 430 |
| pancreas | 100% | 3297.34 | 328 / 328 | 100% | 16.35 | 178 / 178 |
| prostate | 100% | 5789.94 | 245 / 245 | 100% | 19.91 | 502 / 502 |
| skin | 100% | 3795.35 | 1809 / 1809 | 100% | 15.34 | 472 / 472 |
| stomach | 100% | 4440.25 | 359 / 359 | 100% | 13.41 | 286 / 286 |
| thymus | 100% | 6073.06 | 653 / 653 | 100% | 21.77 | 605 / 605 |
| uterus | 100% | 5714.94 | 170 / 170 | 100% | 17.92 | 459 / 459 |
| lung | 100% | 4741.49 | 578 / 578 | 100% | 13.44 | 1154 / 1155 |
| bladder | 100% | 4279.90 | 21 / 21 | 100% | 17.38 | 503 / 504 |
| brain | 100% | 2862.53 | 2634 / 2642 | 100% | 17.97 | 705 / 705 |
| breast | 100% | 5589.18 | 459 / 459 | 100% | 15.09 | 1114 / 1118 |
| intestine | 100% | 4587.25 | 966 / 966 | 100% | 14.21 | 525 / 527 |
| adipose | 100% | 5432.96 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 18.94 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 16.66 | 29 / 29 |
| muscle | 100% | 4718.19 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 5976.73 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 14.36 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 10.33 | 1 / 1 |
| blood vessel | 100% | 4750.38 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 100% | 5077.64 | 927 / 929 | 0% | 0 | 0 / 0 |
| heart | 100% | 3964.88 | 859 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_2000786 | Biological process | positive regulation of autophagosome assembly |
| GO_0030242 | Biological process | autophagy of peroxisome |
| GO_0000045 | Biological process | autophagosome assembly |
| GO_0006497 | Biological process | protein lipidation |
| GO_0034497 | Biological process | protein localization to phagophore assembly site |
| GO_0009267 | Biological process | cellular response to starvation |
| GO_0000422 | Biological process | autophagy of mitochondrion |
| GO_0006914 | Biological process | autophagy |
| GO_0044804 | Biological process | nucleophagy |
| GO_0061723 | Biological process | glycophagy |
| GO_0034045 | Cellular component | phagophore assembly site membrane |
| GO_0019898 | Cellular component | extrinsic component of membrane |
| GO_0005829 | Cellular component | cytosol |
| GO_0000407 | Cellular component | phagophore assembly site |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0032266 | Molecular function | phosphatidylinositol-3-phosphate binding |
| GO_0080025 | Molecular function | phosphatidylinositol-3,5-bisphosphate binding |
| GO_1901981 | Molecular function | phosphatidylinositol phosphate binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | WDR45 |
| Protein name | WD repeat domain 45 WD repeat domain phosphoinositide-interacting protein 4 (WD repeat-containing protein 45) Alternative protein WDR45 WD repeat domain phosphoinositide-interacting protein 4 (WIPI-4) (WD repeat-containing protein 45) |
| Synonyms | WIPI4 WDRX1 hCG_1986580 JM5 WDRXI4 |
| Description | FUNCTION: Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation . Binds phosphatidylinositol 3-phosphate (PtdIns3P) . Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes . Together with WIPI1, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes . Probably recruited to membranes through its PtdIns3P activity . . |
| Accessions | ENST00000486337.6 A0A0U1RRJ2 ENST00000710231.1 [Q9Y484-3] ENST00000635344.1 C9J7Q8 C9JUS5 Q9Y484 ENST00000475880.6 ENST00000376372.9 [Q9Y484-1] ENST00000465382.6 ENST00000635003.1 G8JLI5 ENST00000634671.1 ENST00000710225.1 [Q9Y484-2] A0A0U1RQR1 A0A1B0GV56 ENST00000636049.1 C9JBX7 ENST00000476728.5 ENST00000485908.6 ENST00000367375.8 ENST00000634838.1 ENST00000356463.7 [Q9Y484-3] ENST00000473974.5 A0A0U1RQJ7 A0A0U1RQM7 ENST00000634522.1 ENST00000636645.1 ENST00000471338.6 ENST00000635666.1 C9JE01 A0A0U1RRJ9 H7C5B4 C9J0A8 L0R5G8 A0A0U1RQS7 ENST00000710226.1 [Q9Y484-3] C9J471 H0Y329 A0A0U1RQG6 C9JVT3 ENST00000396681.9 ENST00000475977.2 ENST00000710220.1 [Q9Y484-1] A0A0U1RR42 ENST00000634559.1 ENST00000634849.1 A0A1Y8EKY4 C9JYH8 ENST00000423215.3 H7C4N7 ENST00000322995.13 [Q9Y484-2] A0A0U1RR06 ENST00000634736.1 C9J5L0 ENST00000419567.7 ENST00000376368.7 [Q9Y484-3] ENST00000710219.1 [Q9Y484-1] ENST00000634944.1 [Q9Y484-1] ENST00000474053.6 |