WDR45 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000786Biological processpositive regulation of autophagosome assembly
GO_0030242Biological processautophagy of peroxisome
GO_0000045Biological processautophagosome assembly
GO_0006497Biological processprotein lipidation
GO_0034497Biological processprotein localization to phagophore assembly site
GO_0009267Biological processcellular response to starvation
GO_0000422Biological processautophagy of mitochondrion
GO_0006914Biological processautophagy
GO_0044804Biological processnucleophagy
GO_0061723Biological processglycophagy
GO_0034045Cellular componentphagophore assembly site membrane
GO_0019898Cellular componentextrinsic component of membrane
GO_0005829Cellular componentcytosol
GO_0000407Cellular componentphagophore assembly site
GO_0019901Molecular functionprotein kinase binding
GO_0032266Molecular functionphosphatidylinositol-3-phosphate binding
GO_0080025Molecular functionphosphatidylinositol-3,5-bisphosphate binding
GO_1901981Molecular functionphosphatidylinositol phosphate binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameWDR45
Protein nameWD repeat domain 45
WD repeat domain phosphoinositide-interacting protein 4 (WD repeat-containing protein 45)
Alternative protein WDR45
WD repeat domain phosphoinositide-interacting protein 4 (WIPI-4) (WD repeat-containing protein 45)
SynonymsWIPI4
WDRX1
hCG_1986580
JM5
WDRXI4
DescriptionFUNCTION: Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation . Binds phosphatidylinositol 3-phosphate (PtdIns3P) . Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes . Together with WIPI1, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes . Probably recruited to membranes through its PtdIns3P activity . .

AccessionsENST00000486337.6
A0A0U1RRJ2
ENST00000710231.1 [Q9Y484-3]
ENST00000635344.1
C9J7Q8
C9JUS5
Q9Y484
ENST00000475880.6
ENST00000376372.9 [Q9Y484-1]
ENST00000465382.6
ENST00000635003.1
G8JLI5
ENST00000634671.1
ENST00000710225.1 [Q9Y484-2]
A0A0U1RQR1
A0A1B0GV56
ENST00000636049.1
C9JBX7
ENST00000476728.5
ENST00000485908.6
ENST00000367375.8
ENST00000634838.1
ENST00000356463.7 [Q9Y484-3]
ENST00000473974.5
A0A0U1RQJ7
A0A0U1RQM7
ENST00000634522.1
ENST00000636645.1
ENST00000471338.6
ENST00000635666.1
C9JE01
A0A0U1RRJ9
H7C5B4
C9J0A8
L0R5G8
A0A0U1RQS7
ENST00000710226.1 [Q9Y484-3]
C9J471
H0Y329
A0A0U1RQG6
C9JVT3
ENST00000396681.9
ENST00000475977.2
ENST00000710220.1 [Q9Y484-1]
A0A0U1RR42
ENST00000634559.1
ENST00000634849.1
A0A1Y8EKY4
C9JYH8
ENST00000423215.3
H7C4N7
ENST00000322995.13 [Q9Y484-2]
A0A0U1RR06
ENST00000634736.1
C9J5L0
ENST00000419567.7
ENST00000376368.7 [Q9Y484-3]
ENST00000710219.1 [Q9Y484-1]
ENST00000634944.1 [Q9Y484-1]
ENST00000474053.6