WDR44 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060627Biological processregulation of vesicle-mediated transport
GO_0061824Biological processcytosolic ciliogenesis
GO_1902018Biological processnegative regulation of cilium assembly
GO_0010008Cellular componentendosome membrane
GO_0005829Cellular componentcytosol
GO_0005794Cellular componentGolgi apparatus
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0140313Molecular functionmolecular sequestering activity
GO_0005515Molecular functionprotein binding
GO_0031267Molecular functionsmall GTPase binding

IV. Literature review

[source]
Gene nameWDR44
Protein nameWD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11)
WD repeat-containing protein 44
SynonymsRPH11
hCG_1741667
DescriptionFUNCTION: Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export . ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane . When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis . Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route . .

AccessionsENST00000371848.3
B7Z947
ENST00000254029.8 [Q5JSH3-1]
Q5JSH3
H7BY83
ENST00000371822.9 [Q5JSH3-4]
ENST00000371825.7 [Q5JSH3-2]