Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 9 studies | 25% ± 10% | |
oligodendrocyte | 9 studies | 29% ± 10% | |
interneuron | 6 studies | 31% ± 20% | |
microglial cell | 6 studies | 24% ± 7% | |
GABAergic neuron | 5 studies | 37% ± 17% | |
astrocyte | 5 studies | 24% ± 7% | |
macrophage | 5 studies | 30% ± 4% | |
glutamatergic neuron | 4 studies | 49% ± 14% | |
neuron | 3 studies | 27% ± 12% | |
epithelial cell | 3 studies | 25% ± 5% | |
oligodendrocyte precursor cell | 3 studies | 25% ± 5% | |
alveolar macrophage | 3 studies | 20% ± 4% | |
endothelial cell of lymphatic vessel | 3 studies | 20% ± 2% | |
fibroblast | 3 studies | 17% ± 1% | |
smooth muscle cell | 3 studies | 18% ± 1% | |
type I pneumocyte | 3 studies | 20% ± 5% | |
mast cell | 3 studies | 20% ± 3% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 7 studies | 35% ± 15% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 1676.33 | 1445 / 1445 | 100% | 25.48 | 183 / 183 |
lung | 100% | 1188.52 | 578 / 578 | 100% | 18.25 | 1154 / 1155 |
brain | 100% | 1094.66 | 2639 / 2642 | 100% | 18.91 | 703 / 705 |
thymus | 100% | 1028.61 | 653 / 653 | 99% | 15.80 | 598 / 605 |
breast | 100% | 1249.73 | 459 / 459 | 99% | 19.68 | 1105 / 1118 |
stomach | 100% | 1142.69 | 359 / 359 | 98% | 16.11 | 281 / 286 |
intestine | 100% | 1285.33 | 966 / 966 | 98% | 14.67 | 517 / 527 |
kidney | 100% | 653.04 | 89 / 89 | 97% | 13.74 | 874 / 901 |
uterus | 100% | 1393.82 | 170 / 170 | 97% | 15.88 | 444 / 459 |
prostate | 100% | 1121.79 | 244 / 245 | 97% | 14.12 | 487 / 502 |
bladder | 100% | 1427.86 | 21 / 21 | 96% | 13.71 | 483 / 504 |
ovary | 100% | 1302.18 | 180 / 180 | 95% | 8.88 | 408 / 430 |
pancreas | 96% | 522.12 | 315 / 328 | 98% | 16.74 | 175 / 178 |
skin | 100% | 1091.56 | 1808 / 1809 | 94% | 12.15 | 444 / 472 |
adrenal gland | 100% | 1262.56 | 258 / 258 | 90% | 9.77 | 208 / 230 |
liver | 100% | 664.10 | 226 / 226 | 88% | 9.61 | 358 / 406 |
adipose | 100% | 1378.05 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1782.63 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 1130.16 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 17.74 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 3.40 | 1 / 1 |
muscle | 100% | 948.06 | 802 / 803 | 0% | 0 | 0 / 0 |
heart | 97% | 805.98 | 839 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 90% | 11.84 | 26 / 29 |
peripheral blood | 81% | 599.15 | 750 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 75% | 5.50 | 60 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0060627 | Biological process | regulation of vesicle-mediated transport |
GO_0061824 | Biological process | cytosolic ciliogenesis |
GO_1902018 | Biological process | negative regulation of cilium assembly |
GO_0010008 | Cellular component | endosome membrane |
GO_0005829 | Cellular component | cytosol |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0140313 | Molecular function | molecular sequestering activity |
GO_0005515 | Molecular function | protein binding |
GO_0031267 | Molecular function | small GTPase binding |
Gene name | WDR44 |
Protein name | WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) WD repeat-containing protein 44 |
Synonyms | RPH11 hCG_1741667 |
Description | FUNCTION: Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export . ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane . When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis . Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route . . |
Accessions | ENST00000371848.3 B7Z947 ENST00000254029.8 [Q5JSH3-1] Q5JSH3 H7BY83 ENST00000371822.9 [Q5JSH3-4] ENST00000371825.7 [Q5JSH3-2] |