Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| B cell | 17 studies | 26% ± 11% | |
| plasmacytoid dendritic cell | 14 studies | 29% ± 7% | |
| microglial cell | 11 studies | 47% ± 19% | |
| conventional dendritic cell | 10 studies | 28% ± 10% | |
| dendritic cell | 10 studies | 38% ± 20% | |
| naive B cell | 8 studies | 18% ± 3% | |
| macrophage | 8 studies | 33% ± 13% | |
| memory B cell | 6 studies | 18% ± 2% | |
| myeloid cell | 6 studies | 27% ± 16% | |
| monocyte | 5 studies | 24% ± 6% | |
| alveolar macrophage | 3 studies | 35% ± 10% |
Insufficient scRNA-seq data for expression of WDFY4 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 1474.53 | 578 / 578 | 82% | 4.65 | 943 / 1155 |
| breast | 80% | 289.28 | 365 / 459 | 81% | 3.43 | 902 / 1118 |
| kidney | 62% | 258.24 | 55 / 89 | 77% | 3.07 | 696 / 901 |
| intestine | 82% | 1038.77 | 792 / 966 | 54% | 2.21 | 285 / 527 |
| brain | 51% | 189.92 | 1359 / 2642 | 84% | 3.27 | 593 / 705 |
| thymus | 58% | 306.20 | 379 / 653 | 72% | 2.79 | 435 / 605 |
| bladder | 76% | 289.90 | 16 / 21 | 45% | 1.82 | 225 / 504 |
| stomach | 54% | 157.43 | 195 / 359 | 66% | 3.21 | 189 / 286 |
| esophagus | 64% | 186.76 | 922 / 1445 | 56% | 2.07 | 103 / 183 |
| prostate | 69% | 205.45 | 170 / 245 | 39% | 0.96 | 198 / 502 |
| skin | 42% | 118.20 | 755 / 1809 | 66% | 3.66 | 311 / 472 |
| adrenal gland | 84% | 286.18 | 218 / 258 | 16% | 0.27 | 37 / 230 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 51.31 | 29 / 29 |
| spleen | 100% | 6229.07 | 241 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 100% | 6077.88 | 927 / 929 | 0% | 0 | 0 / 0 |
| uterus | 52% | 116.40 | 89 / 170 | 44% | 1.11 | 203 / 459 |
| pancreas | 19% | 49.44 | 61 / 328 | 75% | 3.76 | 134 / 178 |
| adipose | 94% | 499.92 | 1130 / 1204 | 0% | 0 | 0 / 0 |
| ovary | 44% | 107.49 | 80 / 180 | 48% | 1.16 | 205 / 430 |
| tonsil | 0% | 0 | 0 / 0 | 73% | 4.86 | 33 / 45 |
| blood vessel | 67% | 289.94 | 896 / 1335 | 0% | 0 | 0 / 0 |
| liver | 29% | 66.85 | 65 / 226 | 23% | 0.74 | 93 / 406 |
| heart | 32% | 84.46 | 275 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 19% | 0.35 | 15 / 80 |
| muscle | 2% | 4.27 | 19 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0019882 | Biological process | antigen processing and presentation |
| GO_0098586 | Biological process | cellular response to virus |
| GO_0006914 | Biological process | autophagy |
| GO_0036037 | Biological process | CD8-positive, alpha-beta T cell activation |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005769 | Cellular component | early endosome |
| Gene name | WDFY4 |
| Protein name | WD repeat- and FYVE domain-containing protein 4 WDFY family member 4 WDFY4 protein Truncated WD repeat-and FYVE domain-containing protein 4 |
| Synonyms | C10orf64 KIAA1607 |
| Description | FUNCTION: Plays a critical role in the regulation of cDC1-mediated cross-presentation of viral and tumor antigens in dendritic cells. Mechanistically, acts near the plasma membrane and interacts with endosomal membranes to promote endosomal-to-cytosol antigen trafficking. Also plays a role in B-cell survival through regulation of autophagy. . |
| Accessions | ENST00000490507.1 Q6ZS81 Q6PIM1 A0A1W7HCV9 ENST00000325239.12 [Q6ZS81-1] ENST00000360890.6 [Q6ZS81-2] A0A1W2PQ91 |
