Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 17 studies | 24% ± 9% | |
| oligodendrocyte | 7 studies | 22% ± 6% | |
| ciliated cell | 6 studies | 22% ± 5% | |
| macrophage | 6 studies | 21% ± 5% | |
| epithelial cell | 5 studies | 29% ± 8% | |
| astrocyte | 5 studies | 28% ± 8% | |
| classical monocyte | 4 studies | 26% ± 4% | |
| non-classical monocyte | 4 studies | 26% ± 9% | |
| microglial cell | 4 studies | 23% ± 6% | |
| mast cell | 4 studies | 17% ± 2% | |
| glutamatergic neuron | 4 studies | 42% ± 17% | |
| oligodendrocyte precursor cell | 4 studies | 27% ± 8% | |
| myeloid cell | 3 studies | 30% ± 10% | |
| GABAergic neuron | 3 studies | 40% ± 11% | |
| alveolar macrophage | 3 studies | 29% ± 8% | |
| monocyte | 3 studies | 23% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 2144.32 | 1445 / 1445 | 100% | 31.26 | 183 / 183 |
| lung | 100% | 3860.40 | 578 / 578 | 100% | 29.53 | 1155 / 1155 |
| breast | 100% | 3538.83 | 459 / 459 | 100% | 32.11 | 1117 / 1118 |
| thymus | 100% | 3180.53 | 653 / 653 | 100% | 32.68 | 604 / 605 |
| prostate | 100% | 2572.26 | 245 / 245 | 100% | 28.52 | 501 / 502 |
| uterus | 100% | 3930.98 | 170 / 170 | 100% | 28.52 | 458 / 459 |
| ovary | 100% | 3417.05 | 180 / 180 | 100% | 28.17 | 429 / 430 |
| skin | 100% | 3632.30 | 1808 / 1809 | 100% | 69.56 | 470 / 472 |
| bladder | 100% | 2929.00 | 21 / 21 | 99% | 25.54 | 500 / 504 |
| brain | 99% | 1773.00 | 2619 / 2642 | 100% | 22.79 | 705 / 705 |
| intestine | 100% | 2664.97 | 966 / 966 | 98% | 32.00 | 518 / 527 |
| stomach | 100% | 1972.74 | 359 / 359 | 98% | 32.89 | 281 / 286 |
| kidney | 100% | 1990.65 | 89 / 89 | 98% | 27.99 | 883 / 901 |
| pancreas | 99% | 1330.63 | 324 / 328 | 99% | 30.07 | 176 / 178 |
| adrenal gland | 100% | 2495.19 | 258 / 258 | 95% | 16.03 | 219 / 230 |
| liver | 100% | 1478.18 | 226 / 226 | 92% | 11.55 | 374 / 406 |
| adipose | 100% | 4167.80 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 3836.50 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 75.43 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 30.86 | 29 / 29 |
| spleen | 100% | 2720.85 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 34.91 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 13.43 | 1 / 1 |
| muscle | 100% | 1538.47 | 799 / 803 | 0% | 0 | 0 / 0 |
| heart | 98% | 1586.15 | 848 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 83% | 3019.91 | 772 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0034145 | Biological process | positive regulation of toll-like receptor 4 signaling pathway |
| GO_0034141 | Biological process | positive regulation of toll-like receptor 3 signaling pathway |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0005730 | Cellular component | nucleolus |
| GO_0030054 | Cellular component | cell junction |
| GO_0005829 | Cellular component | cytosol |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0005769 | Cellular component | early endosome |
| GO_0005634 | Cellular component | nucleus |
| GO_0005545 | Molecular function | 1-phosphatidylinositol binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0008270 | Molecular function | zinc ion binding |
| Gene name | WDFY1 |
| Protein name | WD repeat and FYVE domain-containing protein 1 (FYVE domain-containing protein localized to endosomes 1) (FENS-1) (Phosphoinositide-binding protein 1) (WD40- and FYVE domain-containing protein 1) (Zinc finger FYVE domain-containing protein 17) Alternative protein WDFY1 WD repeat and FYVE domain containing 1 |
| Synonyms | FENS1 ZFYVE17 WDF1 KIAA1435 |
| Description | FUNCTION: Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines . . |
| Accessions | L8E905 ENST00000429915.1 ENST00000233055.9 C9JJ54 Q8IWB7 |