WDFY1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034145Biological processpositive regulation of toll-like receptor 4 signaling pathway
GO_0034141Biological processpositive regulation of toll-like receptor 3 signaling pathway
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005730Cellular componentnucleolus
GO_0030054Cellular componentcell junction
GO_0005829Cellular componentcytosol
GO_0005794Cellular componentGolgi apparatus
GO_0005769Cellular componentearly endosome
GO_0005634Cellular componentnucleus
GO_0005545Molecular function1-phosphatidylinositol binding
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameWDFY1
Protein nameWD repeat and FYVE domain-containing protein 1 (FYVE domain-containing protein localized to endosomes 1) (FENS-1) (Phosphoinositide-binding protein 1) (WD40- and FYVE domain-containing protein 1) (Zinc finger FYVE domain-containing protein 17)
Alternative protein WDFY1
WD repeat and FYVE domain containing 1
SynonymsFENS1
ZFYVE17
WDF1
KIAA1435
DescriptionFUNCTION: Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines . .

AccessionsL8E905
ENST00000429915.1
ENST00000233055.9
C9JJ54
Q8IWB7