WASF3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0014003Biological processoligodendrocyte development
GO_0030032Biological processlamellipodium assembly
GO_0030041Biological processactin filament polymerization
GO_0007010Biological processcytoskeleton organization
GO_0065003Biological processprotein-containing complex assembly
GO_0030036Biological processactin cytoskeleton organization
GO_0098885Biological processmodification of postsynaptic actin cytoskeleton
GO_2000601Biological processpositive regulation of Arp2/3 complex-mediated actin nucleation
GO_0008360Biological processregulation of cell shape
GO_0031643Biological processpositive regulation of myelination
GO_0098978Cellular componentglutamatergic synapse
GO_0005856Cellular componentcytoskeleton
GO_0070062Cellular componentextracellular exosome
GO_0098794Cellular componentpostsynapse
GO_0097386Cellular componentglial cell projection
GO_0030027Cellular componentlamellipodium
GO_0031209Cellular componentSCAR complex
GO_0034237Molecular functionprotein kinase A regulatory subunit binding
GO_0071933Molecular functionArp2/3 complex binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene nameWASF3
Protein nameActin-binding protein WASF3 (Protein WAVE-3) (Verprolin homology domain-containing protein 3) (Wiskott-Aldrich syndrome protein family member 3) (WASP family protein member 3)
Wiskott-Aldrich syndrome protein family member (WASP family protein member)
SynonymsWAVE3
hCG_29938
SCAR3
KIAA0900
DescriptionFUNCTION: Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. .

FUNCTION: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. .

FUNCTION: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. .

AccessionsA0A590UJ74
Q9UPY6
ENST00000671038.1
Q5T8P4
ENST00000361042.8 [Q9UPY6-2]
ENST00000335327.6 [Q9UPY6-1]