Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 7 studies | 23% ± 7% | |
microglial cell | 5 studies | 21% ± 6% | |
glutamatergic neuron | 5 studies | 40% ± 18% | |
oligodendrocyte | 5 studies | 22% ± 4% | |
macrophage | 5 studies | 22% ± 5% | |
epithelial cell | 4 studies | 26% ± 9% | |
astrocyte | 4 studies | 29% ± 6% | |
endothelial cell of lymphatic vessel | 4 studies | 18% ± 2% | |
ciliated cell | 3 studies | 19% ± 2% | |
GABAergic neuron | 3 studies | 43% ± 7% | |
oligodendrocyte precursor cell | 3 studies | 28% ± 5% | |
monocyte | 3 studies | 18% ± 2% | |
type II pneumocyte | 3 studies | 21% ± 5% | |
interneuron | 3 studies | 36% ± 19% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 5 studies | 36% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 6657.14 | 459 / 459 | 100% | 38.30 | 1118 / 1118 |
esophagus | 100% | 6536.94 | 1445 / 1445 | 100% | 31.78 | 183 / 183 |
prostate | 100% | 8366.73 | 245 / 245 | 100% | 38.34 | 502 / 502 |
stomach | 100% | 5636.93 | 359 / 359 | 100% | 25.02 | 286 / 286 |
thymus | 100% | 8440.10 | 653 / 653 | 100% | 41.06 | 605 / 605 |
brain | 100% | 6055.56 | 2640 / 2642 | 100% | 56.21 | 705 / 705 |
lung | 100% | 6692.45 | 578 / 578 | 100% | 30.66 | 1153 / 1155 |
uterus | 100% | 7128.28 | 170 / 170 | 100% | 30.26 | 458 / 459 |
kidney | 100% | 5608.39 | 89 / 89 | 100% | 33.41 | 899 / 901 |
intestine | 100% | 7038.41 | 966 / 966 | 100% | 24.46 | 525 / 527 |
adrenal gland | 100% | 8187.53 | 258 / 258 | 100% | 35.90 | 229 / 230 |
pancreas | 100% | 4135.53 | 328 / 328 | 99% | 32.23 | 177 / 178 |
bladder | 100% | 6832.57 | 21 / 21 | 99% | 25.77 | 501 / 504 |
skin | 100% | 7786.64 | 1809 / 1809 | 99% | 40.84 | 468 / 472 |
ovary | 100% | 5670.83 | 180 / 180 | 99% | 23.33 | 426 / 430 |
liver | 100% | 2820.24 | 226 / 226 | 96% | 16.27 | 388 / 406 |
adipose | 100% | 6458.78 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 7011.84 | 1335 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 35.71 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 29.98 | 29 / 29 |
muscle | 100% | 5488.61 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 8945.77 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 29.05 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 13.84 | 1 / 1 |
heart | 99% | 4685.36 | 854 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 98% | 5178.72 | 907 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0035542 | Biological process | regulation of SNARE complex assembly |
GO_0006914 | Biological process | autophagy |
GO_0006886 | Biological process | intracellular protein transport |
GO_0008333 | Biological process | endosome to lysosome transport |
GO_1902774 | Biological process | late endosome to lysosome transport |
GO_0032456 | Biological process | endocytic recycling |
GO_0061909 | Biological process | autophagosome-lysosome fusion |
GO_0034058 | Biological process | endosomal vesicle fusion |
GO_0010008 | Cellular component | endosome membrane |
GO_0031902 | Cellular component | late endosome membrane |
GO_0030897 | Cellular component | HOPS complex |
GO_1902501 | Cellular component | lysosomal HOPS complex |
GO_0005770 | Cellular component | late endosome |
GO_0030123 | Cellular component | AP-3 adaptor complex |
GO_0005765 | Cellular component | lysosomal membrane |
GO_0016020 | Cellular component | membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0005515 | Molecular function | protein binding |
Gene name | VPS39 |
Protein name | VPS39 subunit of HOPS complex Vam6/Vps39-like protein (TRAP1-like protein) (hVam6p) |
Synonyms | KIAA0770 TLP VAM6 |
Description | FUNCTION: Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation. .; FUNCTION: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Acts as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes . Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes . Required for fusion of endosomes and autophagosomes with lysosomes . . |
Accessions | ENST00000348544.4 [Q96JC1-1] H3BTU0 ENST00000318006.10 [Q96JC1-2] ENST00000564994.5 Q96JC1 |