VPS26B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042147Biological processretrograde transport, endosome to Golgi
GO_0006886Biological processintracellular protein transport
GO_0016241Biological processregulation of macroautophagy
GO_0071346Biological processcellular response to type II interferon
GO_0030904Cellular componentretromer complex
GO_0030906Cellular componentretromer, cargo-selective complex
GO_0005768Cellular componentendosome
GO_0005829Cellular componentcytosol
GO_0045335Cellular componentphagocytic vesicle
GO_0005770Cellular componentlate endosome
GO_0005769Cellular componentearly endosome
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameVPS26B
Protein nameVacuolar protein sorting-associated protein 26B (Vesicle protein sorting 26B)
VPS26 retromer complex component B
Synonyms
DescriptionFUNCTION: Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (By similarity). .

AccessionsQ4G0F5
A0A0D9SFQ6
H0YCI7
ENST00000525095.2
ENST00000527586.1
ENST00000281187.10
ENST00000530402.1