VPS18 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of VPS18 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of VPS18 at tissue level.

III. Associated gene sets

GO_0007040Biological processlysosome organization
GO_0016567Biological processprotein ubiquitination
GO_0034058Biological processendosomal vesicle fusion
GO_0006886Biological processintracellular protein transport
GO_0033147Biological processnegative regulation of intracellular estrogen receptor signaling pathway
GO_0046718Biological processsymbiont entry into host cell
GO_0006904Biological processvesicle docking involved in exocytosis
GO_0008333Biological processendosome to lysosome transport
GO_0007032Biological processendosome organization
GO_0048284Biological processorganelle fusion
GO_0035542Biological processregulation of SNARE complex assembly
GO_0006914Biological processautophagy
GO_2000300Biological processregulation of synaptic vesicle exocytosis
GO_0098978Cellular componentglutamatergic synapse
GO_0033263Cellular componentCORVET complex
GO_0098793Cellular componentpresynapse
GO_0031902Cellular componentlate endosome membrane
GO_0030897Cellular componentHOPS complex
GO_0005769Cellular componentearly endosome
GO_0005764Cellular componentlysosome
GO_0030136Cellular componentclathrin-coated vesicle
GO_0030123Cellular componentAP-3 adaptor complex
GO_0005884Cellular componentactin filament
GO_0005770Cellular componentlate endosome
GO_0005776Cellular componentautophagosome
GO_0010008Cellular componentendosome membrane
GO_0005768Cellular componentendosome
GO_0005765Cellular componentlysosomal membrane
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding
GO_0019905Molecular functionsyntaxin binding

IV. Literature review

[source]
Gene nameVPS18
Protein nameVacuolar protein sorting-associated protein 18 homolog (hVPS18)
VPS18 core subunit of CORVET and HOPS complexes
SynonymsKIAA1475
DescriptionFUNCTION: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations . Required for fusion of endosomes and autophagosomes with lysosomes . Involved in dendrite development of Pukinje cells (By similarity). .

AccessionsENST00000558474.1
Q9P253
H0YMC9
H0YLM6
ENST00000220509.10
ENST00000558855.5