VPS11 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of VPS11 at tissue level.

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0034058Biological processendosomal vesicle fusion
GO_2000643Biological processpositive regulation of early endosome to late endosome transport
GO_0006886Biological processintracellular protein transport
GO_0033147Biological processnegative regulation of intracellular estrogen receptor signaling pathway
GO_0007033Biological processvacuole organization
GO_0031647Biological processregulation of protein stability
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0006904Biological processvesicle docking involved in exocytosis
GO_1902115Biological processregulation of organelle assembly
GO_0008333Biological processendosome to lysosome transport
GO_0007032Biological processendosome organization
GO_0048284Biological processorganelle fusion
GO_0035542Biological processregulation of SNARE complex assembly
GO_0006914Biological processautophagy
GO_1903955Biological processpositive regulation of protein targeting to mitochondrion
GO_0033263Cellular componentCORVET complex
GO_0031902Cellular componentlate endosome membrane
GO_0030897Cellular componentHOPS complex
GO_0030139Cellular componentendocytic vesicle
GO_0005769Cellular componentearly endosome
GO_0005764Cellular componentlysosome
GO_0030136Cellular componentclathrin-coated vesicle
GO_0005770Cellular componentlate endosome
GO_0005776Cellular componentautophagosome
GO_0010008Cellular componentendosome membrane
GO_0005768Cellular componentendosome
GO_0005765Cellular componentlysosomal membrane
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0019904Molecular functionprotein domain specific binding
GO_0000166Molecular functionnucleotide binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding
GO_0019905Molecular functionsyntaxin binding

IV. Literature review

[source]
Gene nameVPS11
Protein nameVPS11 core subunit of CORVET and HOPS complexes (Vacuolar protein sorting-associated protein 11 homolog)
Vacuolar protein sorting-associated protein 11 homolog
Vacuolar protein sorting-associated protein 11 homolog (hVPS11) (RING finger protein 108)
SynonymshCG_39399
RNF108
PP3476
DescriptionFUNCTION: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations . Required for fusion of endosomes and autophagosomes with lysosomes . Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes . Involved in the retrograde Shiga toxin transport . .

FUNCTION: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. .

FUNCTION: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. .

AccessionsENST00000614944.4
ENST00000530809.2
ENST00000621676.5
ENST00000629865
A0A087X2J4
ENST00000630977
ENST00000629256
ENST00000626621
A0A0G2JS92
A0A087WXL6
Q9H270
B7Z879