VIRMA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008380Biological processRNA splicing
GO_0006397Biological processmRNA processing
GO_0016556Biological processmRNA modification
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0016604Cellular componentnuclear body
GO_0036396Cellular componentRNA N6-methyladenosine methyltransferase complex
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameVIRMA
Protein nameProtein virilizer homolog
Vir like m6A methyltransferase associated
SynonymsMSTP054
KIAA1429
DescriptionFUNCTION: Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing . Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites . Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA) . .

AccessionsENST00000297591.10 [Q69YN4-1]
Q69YN4
ENST00000522263.5
ENST00000421249.2 [Q69YN4-4]
H0YBN5
ENST00000517624.1
H0YC41
H0YB68
ENST00000523263.1