VAPB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0090114Biological processCOPII-coated vesicle budding
GO_0090158Biological processendoplasmic reticulum membrane organization
GO_0007029Biological processendoplasmic reticulum organization
GO_0061817Biological processendoplasmic reticulum-plasma membrane tethering
GO_0006874Biological processintracellular calcium ion homeostasis
GO_0045070Biological processpositive regulation of viral genome replication
GO_0030968Biological processendoplasmic reticulum unfolded protein response
GO_0036498Biological processIRE1-mediated unfolded protein response
GO_0006888Biological processendoplasmic reticulum to Golgi vesicle-mediated transport
GO_0030301Biological processcholesterol transport
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005794Cellular componentGolgi apparatus
GO_0070971Cellular componentendoplasmic reticulum exit site
GO_0005783Cellular componentendoplasmic reticulum
GO_0005737Cellular componentcytoplasm
GO_0019899Molecular functionenzyme binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0048487Molecular functionbeta-tubulin binding
GO_0045296Molecular functioncadherin binding
GO_0033149Molecular functionFFAT motif binding
GO_0008017Molecular functionmicrotubule binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameVAPB
Protein nameVesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C)
VAMP (Vesicle-associated membrane protein)-associated protein B and C (cDNA FLJ13179 fis, clone NT2RP3003918, highly similar to Vesicle-associated membrane protein-associated protein B/C)
VAMP associated protein B and C
SynonymshCG_26693
UNQ484/PRO983
DescriptionFUNCTION: Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44 . Interacts with STARD3 in a FFAT motif phosphorylation dependent manner . Via interaction with WDR44 participates in neosynthesized protein export . Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity . Involved in cellular calcium homeostasis regulation . .

AccessionsQ53XM7
ENST00000395802.7 [O95292-2]
E5RK64
ENST00000475243.6 [O95292-1]
ENST00000520497.1
O95292