VANGL2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of VANGL2 at tissue level.

III. Associated gene sets

GO_1905515Biological processnon-motile cilium assembly
GO_0036514Biological processdopaminergic neuron axon guidance
GO_0060071Biological processWnt signaling pathway, planar cell polarity pathway
GO_0036515Biological processserotonergic neuron axon guidance
GO_0045176Biological processapical protein localization
GO_0001843Biological processneural tube closure
GO_0035787Biological processcell migration involved in kidney development
GO_0001736Biological processestablishment of planar polarity
GO_0001947Biological processheart looping
GO_0005911Cellular componentcell-cell junction
GO_0016328Cellular componentlateral plasma membrane
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameVANGL2
Protein nameVang-like protein 2 (Loop-tail protein 1 homolog) (Strabismus 1) (Van Gogh-like protein 2)
Vang-like protein
SynonymsKIAA1215
STB1
DescriptionFUNCTION: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity). .

AccessionsENST00000368061.3
A0A8Q3SIN7
Q9ULK5
ENST00000696602.1