Name | Number of supported studies | Average coverage | |
---|---|---|---|
glutamatergic neuron | 9 studies | 41% ± 17% | |
GABAergic neuron | 7 studies | 38% ± 20% | |
microglial cell | 7 studies | 24% ± 8% | |
oligodendrocyte precursor cell | 7 studies | 30% ± 9% | |
fibroblast | 6 studies | 27% ± 12% | |
astrocyte | 6 studies | 35% ± 13% | |
endothelial cell | 5 studies | 29% ± 12% | |
oligodendrocyte | 5 studies | 22% ± 6% | |
amacrine cell | 4 studies | 27% ± 3% | |
retina horizontal cell | 4 studies | 22% ± 4% | |
retinal cone cell | 4 studies | 34% ± 4% | |
interneuron | 4 studies | 40% ± 10% | |
neuron | 3 studies | 30% ± 10% | |
GABAergic interneuron | 3 studies | 38% ± 15% | |
GABAergic amacrine cell | 3 studies | 29% ± 3% | |
glycinergic amacrine cell | 3 studies | 25% ± 4% | |
retinal ganglion cell | 3 studies | 29% ± 15% | |
retinal pigment epithelial cell | 3 studies | 37% ± 18% | |
retinal rod cell | 3 studies | 19% ± 3% | |
epithelial cell | 3 studies | 43% ± 9% | |
macrophage | 3 studies | 30% ± 7% | |
club cell | 3 studies | 25% ± 3% | |
pericyte | 3 studies | 23% ± 8% | |
type I pneumocyte | 3 studies | 21% ± 6% | |
type II pneumocyte | 3 studies | 22% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 4244.12 | 245 / 245 | 99% | 17.50 | 497 / 502 |
brain | 72% | 2109.28 | 1908 / 2642 | 56% | 4.62 | 393 / 705 |
kidney | 78% | 2125.47 | 69 / 89 | 36% | 2.67 | 324 / 901 |
esophagus | 66% | 2119.82 | 953 / 1445 | 46% | 3.10 | 84 / 183 |
bladder | 67% | 2061.62 | 14 / 21 | 45% | 2.98 | 226 / 504 |
lung | 68% | 2396.85 | 395 / 578 | 38% | 2.96 | 444 / 1155 |
pancreas | 63% | 1988.17 | 207 / 328 | 42% | 2.28 | 75 / 178 |
skin | 67% | 1967.99 | 1208 / 1809 | 38% | 2.46 | 180 / 472 |
adrenal gland | 61% | 2394.66 | 158 / 258 | 35% | 3.17 | 80 / 230 |
thymus | 66% | 3284.42 | 434 / 653 | 29% | 2.68 | 175 / 605 |
intestine | 64% | 1996.02 | 619 / 966 | 26% | 1.16 | 138 / 527 |
stomach | 64% | 1583.00 | 228 / 359 | 26% | 1.25 | 73 / 286 |
liver | 70% | 721.89 | 159 / 226 | 13% | 0.55 | 52 / 406 |
adipose | 68% | 1860.89 | 815 / 1204 | 0% | 0 | 0 / 0 |
muscle | 68% | 1227.36 | 543 / 803 | 0% | 0 | 0 / 0 |
heart | 66% | 1500.09 | 568 / 861 | 0% | 0 | 0 / 0 |
blood vessel | 66% | 2036.25 | 878 / 1335 | 0% | 0 | 0 / 0 |
breast | 63% | 1833.17 | 291 / 459 | 1% | 0.09 | 12 / 1118 |
spleen | 64% | 2113.98 | 154 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 56% | 3.84 | 25 / 45 |
lymph node | 0% | 0 | 0 / 0 | 31% | 2.05 | 9 / 29 |
peripheral blood | 27% | 677.03 | 250 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 24% | 1.16 | 19 / 80 |
uterus | 0% | 0 | 0 / 170 | 6% | 0.34 | 29 / 459 |
ovary | 1% | 4.24 | 1 / 180 | 0% | 0 | 0 / 430 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0030509 | Biological process | BMP signaling pathway |
GO_0016579 | Biological process | protein deubiquitination |
GO_0007283 | Biological process | spermatogenesis |
GO_0007179 | Biological process | transforming growth factor beta receptor signaling pathway |
GO_0006508 | Biological process | proteolysis |
GO_0016477 | Biological process | cell migration |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0070410 | Molecular function | co-SMAD binding |
GO_0008234 | Molecular function | cysteine-type peptidase activity |
GO_0004843 | Molecular function | cysteine-type deubiquitinase activity |
GO_0046872 | Molecular function | metal ion binding |
Gene name | USP9Y |
Protein name | Alternative protein USP9Y Ubiquitin specific peptidase 9 Y-linked Probable ubiquitin carboxyl-terminal hydrolase FAF-Y (EC 3.4.19.12) (Deubiquitinating enzyme FAF-Y) (Fat facets protein-related, Y-linked) (Ubiquitin thioesterase FAF-Y) (Ubiquitin-specific protease 9, Y chromosome) (Ubiquitin-specific-processing protease FAF-Y) |
Synonyms | DFFRY |
Description | FUNCTION: May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiquitination of SMAD4 by USP9X re-empowers its competence to mediate TGF-beta signaling (By similarity). . |
Accessions | ENST00000453031.1 ENST00000651177.1 [O00507-1] H7C2M9 L8E838 ENST00000338981.7 [O00507-1] O00507 |