Name | Number of supported studies | Average coverage | |
---|---|---|---|
B cell | 11 studies | 18% ± 3% | |
endothelial cell | 8 studies | 25% ± 9% | |
ciliated cell | 7 studies | 23% ± 6% | |
epithelial cell | 6 studies | 33% ± 12% | |
astrocyte | 6 studies | 25% ± 7% | |
oligodendrocyte | 6 studies | 21% ± 5% | |
glutamatergic neuron | 5 studies | 37% ± 15% | |
retinal rod cell | 5 studies | 22% ± 4% | |
GABAergic neuron | 5 studies | 33% ± 11% | |
neuron | 4 studies | 25% ± 7% | |
precursor B cell | 4 studies | 29% ± 10% | |
retinal cone cell | 4 studies | 27% ± 11% | |
pro-B cell | 3 studies | 31% ± 5% | |
amacrine cell | 3 studies | 38% ± 7% | |
fibroblast | 3 studies | 21% ± 4% | |
Mueller cell | 3 studies | 20% ± 4% | |
oligodendrocyte precursor cell | 3 studies | 27% ± 4% | |
dendritic cell | 3 studies | 25% ± 6% | |
abnormal cell | 3 studies | 22% ± 5% | |
basal cell | 3 studies | 31% ± 12% | |
transit amplifying cell | 3 studies | 34% ± 21% | |
interneuron | 3 studies | 39% ± 15% | |
plasmacytoid dendritic cell | 3 studies | 24% ± 5% | |
natural killer cell | 3 studies | 20% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
bladder | 100% | 1209.67 | 21 / 21 | 100% | 22.37 | 504 / 504 |
brain | 100% | 1455.82 | 2642 / 2642 | 100% | 25.13 | 705 / 705 |
uterus | 100% | 1426.86 | 170 / 170 | 100% | 36.04 | 459 / 459 |
esophagus | 100% | 1160.89 | 1444 / 1445 | 100% | 28.87 | 183 / 183 |
thymus | 100% | 1441.41 | 653 / 653 | 100% | 18.48 | 604 / 605 |
intestine | 100% | 1239.93 | 966 / 966 | 100% | 23.06 | 526 / 527 |
prostate | 100% | 1309.11 | 245 / 245 | 100% | 15.51 | 501 / 502 |
lung | 100% | 1053.95 | 578 / 578 | 99% | 22.60 | 1147 / 1155 |
stomach | 100% | 796.41 | 359 / 359 | 99% | 22.80 | 284 / 286 |
breast | 100% | 1153.01 | 459 / 459 | 99% | 19.37 | 1108 / 1118 |
ovary | 100% | 1432.19 | 180 / 180 | 99% | 18.40 | 425 / 430 |
pancreas | 100% | 517.19 | 327 / 328 | 99% | 16.88 | 176 / 178 |
adrenal gland | 100% | 813.74 | 258 / 258 | 98% | 15.90 | 225 / 230 |
skin | 100% | 1114.09 | 1808 / 1809 | 96% | 19.60 | 452 / 472 |
kidney | 100% | 959.02 | 89 / 89 | 94% | 10.98 | 844 / 901 |
liver | 100% | 741.41 | 226 / 226 | 92% | 10.81 | 374 / 406 |
adipose | 100% | 1071.41 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1188.56 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 27.79 | 29 / 29 |
spleen | 100% | 1226.55 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 30.93 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 10.67 | 1 / 1 |
muscle | 100% | 836.85 | 800 / 803 | 0% | 0 | 0 / 0 |
heart | 99% | 539.40 | 849 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 69% | 754.03 | 643 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 53% | 5.67 | 42 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007420 | Biological process | brain development |
GO_1905746 | Biological process | positive regulation of mRNA cis splicing, via spliceosome |
GO_0045727 | Biological process | positive regulation of translation |
GO_0045666 | Biological process | positive regulation of neuron differentiation |
GO_0031175 | Biological process | neuron projection development |
GO_0000184 | Biological process | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
GO_0051028 | Biological process | mRNA transport |
GO_0005730 | Cellular component | nucleolus |
GO_0035145 | Cellular component | exon-exon junction complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0043025 | Cellular component | neuronal cell body |
GO_0034451 | Cellular component | centriolar satellite |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0005515 | Molecular function | protein binding |
GO_0003729 | Molecular function | mRNA binding |
GO_0003723 | Molecular function | RNA binding |
Gene name | UPF3B |
Protein name | UPF3B protein Nonfunctional UPF3B regulator of nonsense mediated mRNA decay Mutant R430X UPF3B Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (Up-frameshift suppressor 3 homolog on chromosome X) (hUpf3p-X) |
Synonyms | RENT3B UPF3X |
Description | FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core. . |
Accessions | I3XIE4 ENST00000345865.6 [Q9BZI7-2] Q0VAK7 A0A6H0C8C5 ENST00000276201.7 [Q9BZI7-1] Q9BZI7 |