UPF3B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007420Biological processbrain development
GO_1905746Biological processpositive regulation of mRNA cis splicing, via spliceosome
GO_0045727Biological processpositive regulation of translation
GO_0045666Biological processpositive regulation of neuron differentiation
GO_0031175Biological processneuron projection development
GO_0000184Biological processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO_0051028Biological processmRNA transport
GO_0005730Cellular componentnucleolus
GO_0035145Cellular componentexon-exon junction complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0043025Cellular componentneuronal cell body
GO_0034451Cellular componentcentriolar satellite
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003729Molecular functionmRNA binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameUPF3B
Protein nameUPF3B protein
Nonfunctional UPF3B regulator of nonsense mediated mRNA decay
Mutant R430X UPF3B
Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (Up-frameshift suppressor 3 homolog on chromosome X) (hUpf3p-X)
SynonymsRENT3B
UPF3X
DescriptionFUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core. .

AccessionsI3XIE4
ENST00000345865.6 [Q9BZI7-2]
Q0VAK7
A0A6H0C8C5
ENST00000276201.7 [Q9BZI7-1]
Q9BZI7