UCHL5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_0032435Biological processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0045995Biological processregulation of embryonic development
GO_0045739Biological processpositive regulation of DNA repair
GO_0006282Biological processregulation of DNA repair
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0060382Biological processregulation of DNA strand elongation
GO_1904507Biological processpositive regulation of telomere maintenance in response to DNA damage
GO_0006338Biological processchromatin remodeling
GO_0045880Biological processpositive regulation of smoothened signaling pathway
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0021670Biological processlateral ventricle development
GO_0000723Biological processtelomere maintenance
GO_0016579Biological processprotein deubiquitination
GO_0033044Biological processregulation of chromosome organization
GO_0006310Biological processDNA recombination
GO_0006275Biological processregulation of DNA replication
GO_0061136Biological processregulation of proteasomal protein catabolic process
GO_0048853Biological processforebrain morphogenesis
GO_0030901Biological processmidbrain development
GO_0051726Biological processregulation of cell cycle
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0031597Cellular componentcytosolic proteasome complex
GO_0031011Cellular componentIno80 complex
GO_0005634Cellular componentnucleus
GO_0070628Molecular functionproteasome binding
GO_0004843Molecular functioncysteine-type deubiquitinase activity
GO_0004866Molecular functionendopeptidase inhibitor activity
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUCHL5
Protein nameUbiquitin carboxyl-terminal hydrolase isozyme L5 (UCH-L5) (EC 3.4.19.12) (Ubiquitin C-terminal hydrolase UCH37) (Ubiquitin thioesterase L5)
Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12)
ubiquitinyl hydrolase 1 (EC 3.4.19.12)
Ubiquitin C-terminal hydrolase L5
SynonymsCGI-70
AD-019
UCH37
DescriptionFUNCTION: Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1. .

AccessionsENST00000420791.5
ENST00000367451.8
Q9Y5K5
H0Y6Y4
ENST00000367454.6 [Q9Y5K5-3]
ENST00000367449.5 [Q9Y5K5-2]
ENST00000367450.7
ENST00000449480.5
H0Y636
ENST00000367455.8 [Q9Y5K5-1]
Q5LJB0
H0Y4E0
Q5LJB1
ENST00000443327.5
Q5LJA5
H0Y4K0
ENST00000417752.1
ENST00000416915.1
Q5LJA9
ENST00000367448.5 [Q9Y5K5-4]
ENST00000421683.1