Name | Number of supported studies | Average coverage | |
---|---|---|---|
natural killer cell | 14 studies | 21% ± 5% | |
CD16-positive, CD56-dim natural killer cell, human | 8 studies | 21% ± 5% | |
epithelial cell | 6 studies | 27% ± 7% | |
CD16-negative, CD56-bright natural killer cell, human | 5 studies | 18% ± 2% | |
plasmablast | 4 studies | 40% ± 22% | |
mature NK T cell | 4 studies | 17% ± 1% | |
endothelial cell | 4 studies | 21% ± 4% | |
glutamatergic neuron | 4 studies | 47% ± 18% | |
oligodendrocyte | 4 studies | 21% ± 3% | |
neuron | 3 studies | 21% ± 6% | |
retinal cone cell | 3 studies | 32% ± 4% | |
ciliated cell | 3 studies | 19% ± 3% | |
effector CD8-positive, alpha-beta T cell | 3 studies | 19% ± 2% | |
GABAergic neuron | 3 studies | 43% ± 5% | |
dendritic cell | 3 studies | 22% ± 2% | |
macrophage | 3 studies | 18% ± 2% | |
basal cell | 3 studies | 25% ± 3% | |
interneuron | 3 studies | 37% ± 17% | |
plasmacytoid dendritic cell | 3 studies | 24% ± 3% | |
astrocyte | 3 studies | 24% ± 8% | |
CD8-positive, alpha-beta T cell | 3 studies | 24% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 1516.62 | 459 / 459 | 100% | 26.93 | 1118 / 1118 |
esophagus | 100% | 1550.67 | 1445 / 1445 | 100% | 20.75 | 183 / 183 |
ovary | 100% | 1282.04 | 180 / 180 | 100% | 13.86 | 430 / 430 |
brain | 100% | 2129.03 | 2641 / 2642 | 100% | 18.99 | 705 / 705 |
prostate | 100% | 1320.58 | 245 / 245 | 100% | 19.18 | 501 / 502 |
uterus | 100% | 1215.15 | 170 / 170 | 100% | 23.01 | 458 / 459 |
lung | 100% | 1304.51 | 576 / 578 | 100% | 22.05 | 1155 / 1155 |
pancreas | 100% | 1319.50 | 328 / 328 | 99% | 13.13 | 177 / 178 |
liver | 100% | 1190.13 | 226 / 226 | 99% | 16.95 | 403 / 406 |
bladder | 100% | 1329.48 | 21 / 21 | 99% | 18.70 | 499 / 504 |
intestine | 100% | 1454.85 | 966 / 966 | 99% | 19.39 | 521 / 527 |
stomach | 100% | 1155.77 | 359 / 359 | 99% | 17.98 | 282 / 286 |
kidney | 100% | 1199.93 | 89 / 89 | 97% | 13.51 | 870 / 901 |
skin | 100% | 1858.42 | 1808 / 1809 | 94% | 23.22 | 446 / 472 |
adrenal gland | 100% | 1564.61 | 258 / 258 | 94% | 13.17 | 217 / 230 |
thymus | 100% | 1104.95 | 652 / 653 | 90% | 8.53 | 547 / 605 |
adipose | 100% | 1513.62 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 24.24 | 29 / 29 |
muscle | 100% | 1992.67 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 1370.51 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 20.50 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 9.04 | 1 / 1 |
blood vessel | 100% | 1373.48 | 1333 / 1335 | 0% | 0 | 0 / 0 |
heart | 97% | 1377.60 | 833 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 74% | 1366.32 | 686 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 63% | 7.52 | 50 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006281 | Biological process | DNA repair |
GO_0032435 | Biological process | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
GO_0045995 | Biological process | regulation of embryonic development |
GO_0045739 | Biological process | positive regulation of DNA repair |
GO_0006282 | Biological process | regulation of DNA repair |
GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
GO_0060382 | Biological process | regulation of DNA strand elongation |
GO_1904507 | Biological process | positive regulation of telomere maintenance in response to DNA damage |
GO_0006338 | Biological process | chromatin remodeling |
GO_0045880 | Biological process | positive regulation of smoothened signaling pathway |
GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
GO_0021670 | Biological process | lateral ventricle development |
GO_0000723 | Biological process | telomere maintenance |
GO_0016579 | Biological process | protein deubiquitination |
GO_0033044 | Biological process | regulation of chromosome organization |
GO_0006310 | Biological process | DNA recombination |
GO_0006275 | Biological process | regulation of DNA replication |
GO_0061136 | Biological process | regulation of proteasomal protein catabolic process |
GO_0048853 | Biological process | forebrain morphogenesis |
GO_0030901 | Biological process | midbrain development |
GO_0051726 | Biological process | regulation of cell cycle |
GO_0005730 | Cellular component | nucleolus |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0031597 | Cellular component | cytosolic proteasome complex |
GO_0031011 | Cellular component | Ino80 complex |
GO_0005634 | Cellular component | nucleus |
GO_0070628 | Molecular function | proteasome binding |
GO_0004843 | Molecular function | cysteine-type deubiquitinase activity |
GO_0004866 | Molecular function | endopeptidase inhibitor activity |
GO_0003723 | Molecular function | RNA binding |
GO_0005515 | Molecular function | protein binding |
Gene name | UCHL5 |
Protein name | Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCH-L5) (EC 3.4.19.12) (Ubiquitin C-terminal hydrolase UCH37) (Ubiquitin thioesterase L5) Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) ubiquitinyl hydrolase 1 (EC 3.4.19.12) Ubiquitin C-terminal hydrolase L5 |
Synonyms | CGI-70 AD-019 UCH37 |
Description | FUNCTION: Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1. . |
Accessions | ENST00000420791.5 ENST00000367451.8 Q9Y5K5 H0Y6Y4 ENST00000367454.6 [Q9Y5K5-3] ENST00000367449.5 [Q9Y5K5-2] ENST00000367450.7 ENST00000449480.5 H0Y636 ENST00000367455.8 [Q9Y5K5-1] Q5LJB0 H0Y4E0 Q5LJB1 ENST00000443327.5 Q5LJA5 H0Y4K0 ENST00000417752.1 ENST00000416915.1 Q5LJA9 ENST00000367448.5 [Q9Y5K5-4] ENST00000421683.1 |