UBE2W report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_0006515Biological processprotein quality control for misfolded or incompletely synthesized proteins
GO_0006513Biological processprotein monoubiquitination
GO_0070979Biological processprotein K11-linked ubiquitination
GO_0071218Biological processcellular response to misfolded protein
GO_0000209Biological processprotein polyubiquitination
GO_0140374Biological processantiviral innate immune response
GO_1904262Biological processnegative regulation of TORC1 signaling
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0061631Molecular functionubiquitin conjugating enzyme activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameUBE2W
Protein nameUbiquitin conjugating enzyme E2 W
N-terminal E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) (EC 2.3.2.25)
Ubiquitin-conjugating enzyme E2 W (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme W) (N-terminal E2 ubiquitin-conjugating enzyme) (EC 2.3.2.25) (N-terminus-conjugating E2) (Ubiquitin carrier protein W) (Ubiquitin-conjugating enzyme 16) (UBC-16) (Ubiquitin-protein ligase W)
SynonymsUBC16
DescriptionFUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins . Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini . Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway . In vitro catalyzes 'Lys-11'-linked polyubiquitination. UBE2W-catalyzed ubiquitination occurs also in the presence of inactive RING/U-box type E3s, i.e. lacking the active site cysteine residues to form thioester bonds with ubiquitin, or even in the absence of E3, albeit at a slower rate . .

AccessionsENST00000517608.5 [Q96B02-3]
ENST00000523278.5
E5RG25
X6REH9
ENST00000519255.2
Q96FI0
H0YB73
ENST00000602593.6 [Q96B02-1]
ENST00000651945.1 [Q96B02-2]
ENST00000422906.6
Q96B02
ENST00000419880.7
ENST00000519277.5
ENST00000650817.1