UBE2C | OmnibusX

Name	Number of supported studies	Average coverage
T cell	7 studies	30% ± 12%	Explore
B cell	5 studies	25% ± 6%	Explore
plasmablast	5 studies	36% ± 13%	Explore
transit amplifying cell	5 studies	30% ± 9%	Explore
CD8-positive, alpha-beta T cell	5 studies	39% ± 17%	Explore
epithelial cell	4 studies	32% ± 17%	Explore
erythroblast	4 studies	30% ± 7%	Explore
erythrocyte	4 studies	32% ± 11%	Explore
CD4-positive, alpha-beta T cell	4 studies	55% ± 11%	Explore
endothelial cell	3 studies	17% ± 3%	Explore
conventional dendritic cell	3 studies	18% ± 1%	Explore
plasma cell	3 studies	31% ± 5%	Explore
pro-B cell	3 studies	23% ± 3%	Explore
natural killer cell	3 studies	34% ± 10%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	31% ± 16%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of UBE2C at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	93%	1141.29	1684 / 1809	94%	124.01	443 / 472
lung	70%	205.48	407 / 578	84%	138.34	975 / 1155
intestine	56%	367.39	545 / 966	96%	215.40	508 / 527
stomach	50%	273.09	178 / 359	96%	220.52	274 / 286
esophagus	43%	447.98	625 / 1445	98%	165.33	180 / 183
bladder	38%	65.48	8 / 21	96%	220.45	485 / 504
uterus	15%	30.66	25 / 170	98%	265.92	452 / 459
ovary	11%	37.66	19 / 180	99%	235.78	426 / 430
breast	22%	40.37	100 / 459	80%	109.08	897 / 1118
lymph node	0%	0	0 / 0	100%	162.87	29 / 29
tonsil	0%	0	0 / 0	100%	197.63	45 / 45
ureter	0%	0	0 / 0	100%	122.91	1 / 1
spleen	98%	563.60	237 / 241	0%	0	0 / 0
peripheral blood	94%	1286.29	875 / 929	0%	0	0 / 0
pancreas	7%	10.75	22 / 328	71%	74.51	126 / 178
adrenal gland	41%	83.01	105 / 258	20%	24.73	46 / 230
liver	15%	48.40	35 / 226	39%	32.82	160 / 406
brain	2%	3.95	51 / 2642	37%	42.31	258 / 705
kidney	24%	65.10	21 / 89	10%	9.98	94 / 901
prostate	23%	37.66	56 / 245	11%	7.55	54 / 502
thymus	15%	25.53	96 / 653	14%	34.65	83 / 605
adipose	24%	51.02	294 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	15%	7.42	12 / 80
blood vessel	14%	21.26	193 / 1335	0%	0	0 / 0
heart	9%	17.68	77 / 861	0%	0	0 / 0
muscle	2%	2.48	20 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0016567	Biological process	protein ubiquitination
GO_0030071	Biological process	regulation of mitotic metaphase/anaphase transition
GO_0070979	Biological process	protein K11-linked ubiquitination
GO_0000209	Biological process	protein polyubiquitination
GO_0045842	Biological process	positive regulation of mitotic metaphase/anaphase transition
GO_0006511	Biological process	ubiquitin-dependent protein catabolic process
GO_0051301	Biological process	cell division
GO_0031536	Biological process	positive regulation of exit from mitosis
GO_0010994	Biological process	free ubiquitin chain polymerization
GO_1904668	Biological process	positive regulation of ubiquitin protein ligase activity
GO_0031145	Biological process	anaphase-promoting complex-dependent catabolic process
GO_0070936	Biological process	protein K48-linked ubiquitination
GO_0010458	Biological process	exit from mitosis
GO_0000151	Cellular component	ubiquitin ligase complex
GO_0005680	Cellular component	anaphase-promoting complex
GO_0005886	Cellular component	plasma membrane
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005634	Cellular component	nucleus
GO_0061630	Molecular function	ubiquitin protein ligase activity
GO_0005524	Molecular function	ATP binding
GO_0004842	Molecular function	ubiquitin-protein transferase activity
GO_0061631	Molecular function	ubiquitin conjugating enzyme activity
GO_0005515	Molecular function	protein binding
GO_0044389	Molecular function	ubiquitin-like protein ligase binding

Gene name	UBE2C
Protein name	Ubiquitin-conjugating enzyme E2 C (EC 2.3.2.23) (EC 2.3.2.24) ((E3-independent) E2 ubiquitin-conjugating enzyme C) (E2 ubiquitin-conjugating enzyme C) (Ubiquitin carrier protein C) (Ubiquitin-protein ligase C) Ubiquitin-conjugating enzyme E2 C (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme C) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme C) (UbcH10) (Ubiquitin carrier protein C) (Ubiquitin-protein ligase C) Ubiquitin conjugating enzyme E2 C (Ubiquitin-conjugating enzyme E2C, isoform CRA_d) Ubiquitin conjugating enzyme E2 C
Synonyms	hCG_38372 UBCH10
Description	FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit. .
Accessions	ENST00000335046.7 [O00762-4] ENST00000617055.4 A0A0A0MSE8 ENST00000405520.5 ENST00000372568.4 [O00762-2] A0A087WVK1 ENST00000243893.10 K4DI81 ENST00000356455.9 [O00762-1] ENST00000352551.9 [O00762-3] Q5TZN3 O00762

UBE2C report